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Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation.
Eur J Pharmacol. 2004 Nov 28; 505(1-3):195-203.EJ

Abstract

Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nuclear hormone receptor super family that has recently been implicated in atherosclerosis, inflammation, cancer, infertility, and demyelination. Oxidative stress, neutrophil infiltration, proinflammatory cytokines, and the exhibition of luminal acid play a role in the pathogenesis of gastric injury induced by ischemia-reperfusion. Rosiglitazone, a specific PPAR-gamma ligand, has been shown to have antiinflammatory activity, but its effects on experimental ischemia-reperfusion gastric injury remain unknown. We have investigated the effects of the rosiglitazone on gastric injury caused by ischemia following reperfusion in rats. Tumour necrosis factor-alpha (TNF-alpha) levels and changes in enzymatic activities of myeloperoxidase, as a marker of neutrophils infiltration, xanthine oxidase, superoxide dismutase, and glutathione peroxidase, were determined. Histological analysis of the lesions was also carried out. Pretreatment with 1 or 4 mg/kg of rosiglitazone ameliorated the gastric damage induced by clamping the celiac artery for 30 min followed by 60 min of reperfusion. It significantly (P<0.05) reduced the index of neutrophil infiltration and the levels of the cytokine. Rosiglitazone did not revert the reduced glutathione peroxidase activity but enhanced significantly (P<0.01) the decreased xanthine oxidase and superoxide dismutase activities in gastric mucosa of ischemic rats. In conclusion, rosiglitazone reduces the damage in ischemia-reperfusion gastric injury and alleviates the inflammatory response and the oxidative events.

Authors+Show Affiliations

Villegas I
Department of Pharmacology, Faculty of Pharmacy, University of Sevilla, Professor García González Street, 41012 Seville, Spain.
Martín AR
No affiliation info available
Toma W
No affiliation info available
de la Lastra CA
No affiliation info available

MeSH

AnimalsCyclooxygenase 1Cyclooxygenase 2Gastric MucosaGlutathione PeroxidaseImmunohistochemistryMaleMembrane ProteinsNecrosisNeutrophilsOxidative StressPPAR gammaPeroxidaseProstaglandin-Endoperoxide SynthasesRatsRats, WistarReactive Oxygen SpeciesReperfusion InjuryRosiglitazoneStomachSuperoxide DismutaseThiazolidinedionesTumor Necrosis Factor-alphaUp-RegulationXanthine Oxidase

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15556153

Citation

Villegas, Isabel, et al. "Rosiglitazone, an Agonist of Peroxisome Proliferator-activated Receptor Gamma, Protects Against Gastric Ischemia-reperfusion Damage in Rats: Role of Oxygen Free Radicals Generation." European Journal of Pharmacology, vol. 505, no. 1-3, 2004, pp. 195-203.
Villegas I, Martín AR, Toma W, et al. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation. Eur J Pharmacol. 2004;505(1-3):195-203.
Villegas, I., Martín, A. R., Toma, W., & de la Lastra, C. A. (2004). Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation. European Journal of Pharmacology, 505(1-3), 195-203.
Villegas I, et al. Rosiglitazone, an Agonist of Peroxisome Proliferator-activated Receptor Gamma, Protects Against Gastric Ischemia-reperfusion Damage in Rats: Role of Oxygen Free Radicals Generation. Eur J Pharmacol. 2004 Nov 28;505(1-3):195-203. PubMed PMID: 15556153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rosiglitazone, an agonist of peroxisome proliferator-activated receptor gamma, protects against gastric ischemia-reperfusion damage in rats: role of oxygen free radicals generation. AU - Villegas,Isabel, AU - Martín,Antonio Ramón, AU - Toma,Walber, AU - de la Lastra,Catalina Alarcón, PY - 2004/06/10/received PY - 2004/09/24/revised PY - 2004/10/04/accepted PY - 2004/11/24/pubmed PY - 2005/5/17/medline PY - 2004/11/24/entrez SP - 195 EP - 203 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 505 IS - 1-3 N2 - Peroxisome proliferator-activated receptor gamma (PPAR-gamma) is a nuclear hormone receptor super family that has recently been implicated in atherosclerosis, inflammation, cancer, infertility, and demyelination. Oxidative stress, neutrophil infiltration, proinflammatory cytokines, and the exhibition of luminal acid play a role in the pathogenesis of gastric injury induced by ischemia-reperfusion. Rosiglitazone, a specific PPAR-gamma ligand, has been shown to have antiinflammatory activity, but its effects on experimental ischemia-reperfusion gastric injury remain unknown. We have investigated the effects of the rosiglitazone on gastric injury caused by ischemia following reperfusion in rats. Tumour necrosis factor-alpha (TNF-alpha) levels and changes in enzymatic activities of myeloperoxidase, as a marker of neutrophils infiltration, xanthine oxidase, superoxide dismutase, and glutathione peroxidase, were determined. Histological analysis of the lesions was also carried out. Pretreatment with 1 or 4 mg/kg of rosiglitazone ameliorated the gastric damage induced by clamping the celiac artery for 30 min followed by 60 min of reperfusion. It significantly (P<0.05) reduced the index of neutrophil infiltration and the levels of the cytokine. Rosiglitazone did not revert the reduced glutathione peroxidase activity but enhanced significantly (P<0.01) the decreased xanthine oxidase and superoxide dismutase activities in gastric mucosa of ischemic rats. In conclusion, rosiglitazone reduces the damage in ischemia-reperfusion gastric injury and alleviates the inflammatory response and the oxidative events. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15556153/Rosiglitazone_an_agonist_of_peroxisome_proliferator_activated_receptor_gamma_protects_against_gastric_ischemia_reperfusion_damage_in_rats:_role_of_oxygen_free_radicals_generation_ DB - PRIME DP - Unbound Medicine ER -