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Effect of inactivation of the HtrA-like serine protease DegQ on the virulence of Salmonella enterica serovar Typhimurium in mice.
Infect Immun. 2004 Dec; 72(12):7357-9.II

Abstract

DegQ is a serine protease that is highly homologous to HtrA, an important virulence determinant of Salmonella enterica serovar Typhimurium. We examined if DegQ is involved in serovar Typhimurium pathogenesis. A serovar Typhimurium degQ mutant was as virulent as the wild-type strain in mice. However, a serovar Typhimurium htrA degQ mutant survived less well in murine organs, particularly in the liver, than a serovar Typhimurium htrA mutant. DegQ is not essential for serovar Typhimurium pathogenesis but may play a small role during salmonella growth at systemic sites.

Authors+Show Affiliations

Institute of Comparative Medicine, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, Glasgow G61 1QH, Scotland, United Kingdom.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15557668

Citation

Farn, Jacinta, and Mark Roberts. "Effect of Inactivation of the HtrA-like Serine Protease DegQ On the Virulence of Salmonella Enterica Serovar Typhimurium in Mice." Infection and Immunity, vol. 72, no. 12, 2004, pp. 7357-9.
Farn J, Roberts M. Effect of inactivation of the HtrA-like serine protease DegQ on the virulence of Salmonella enterica serovar Typhimurium in mice. Infect Immun. 2004;72(12):7357-9.
Farn, J., & Roberts, M. (2004). Effect of inactivation of the HtrA-like serine protease DegQ on the virulence of Salmonella enterica serovar Typhimurium in mice. Infection and Immunity, 72(12), 7357-9.
Farn J, Roberts M. Effect of Inactivation of the HtrA-like Serine Protease DegQ On the Virulence of Salmonella Enterica Serovar Typhimurium in Mice. Infect Immun. 2004;72(12):7357-9. PubMed PMID: 15557668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of inactivation of the HtrA-like serine protease DegQ on the virulence of Salmonella enterica serovar Typhimurium in mice. AU - Farn,Jacinta, AU - Roberts,Mark, PY - 2004/11/24/pubmed PY - 2004/12/31/medline PY - 2004/11/24/entrez SP - 7357 EP - 9 JF - Infection and immunity JO - Infect Immun VL - 72 IS - 12 N2 - DegQ is a serine protease that is highly homologous to HtrA, an important virulence determinant of Salmonella enterica serovar Typhimurium. We examined if DegQ is involved in serovar Typhimurium pathogenesis. A serovar Typhimurium degQ mutant was as virulent as the wild-type strain in mice. However, a serovar Typhimurium htrA degQ mutant survived less well in murine organs, particularly in the liver, than a serovar Typhimurium htrA mutant. DegQ is not essential for serovar Typhimurium pathogenesis but may play a small role during salmonella growth at systemic sites. SN - 0019-9567 UR - https://www.unboundmedicine.com/medline/citation/15557668/Effect_of_inactivation_of_the_HtrA_like_serine_protease_DegQ_on_the_virulence_of_Salmonella_enterica_serovar_Typhimurium_in_mice_ L2 - https://journals.asm.org/doi/10.1128/IAI.72.12.7357-7359.2004?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -