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Stability of drug additives in peritoneal dialysis solutions in a new container.
Perit Dial Int 2004 Nov-Dec; 24(6):590-5PD

Abstract

OBJECTIVE

To evaluate the stability of gentamicin, tobramycin, netilmycin, vancomycin, cefazolin, unfractionated heparin, and low molecular weight heparin when added to four different peritoneal dialysis (PD) solutions [Extraneal (Baxter Healthcare, Castlebar, Ireland); Physioneal, Nutrineal, and Dianeal (Baxter Healthcare, Grosotto, Italy)] in new, non-PVC Clear-Flex containers.

MEASUREMENTS

Gentamicin, tobramycin, netilmycin, vancomycin, cefazolin, unfractionated heparin, and low molecular weight heparin were injected into separate bags of PD solution. Samples were withdrawn at predefined sampling times and the concentration of each drug was analyzed using high-performance liquid chromatography (for gentamicin, tobramycin, vancomycin, and cefazolin), or bioassay (for netilmycin, gentamicin, and tobramycin in Nutrineal), or coagulation methods (heparins).

RESULTS

Netilmycin, vancomycin, cefazolin, and heparin in Physioneal, Nutrineal, Extraneal, and Dianeal were stable for at least 24 hours at 25 degrees C and for an additional 4 hours at 37 degrees C. Gentamicin in Nutrineal, Extraneal, and Dianeal was stable for at least 24 hours at 25 degrees C and for an additional 4 hours at 37 degrees C; gentamicin in Physioneal was stable for less than 24 hours at 25 degrees C. Tobramycin in Nutrineal and Extraneal was stable for at least 24 hours at 25 degrees C and for an additional 4 hours at 37 degrees C; tobramycin in Physioneal and Dianeal was stable for less than 24 hours at 25 degrees C.

Authors+Show Affiliations

Baxter R&D Europe, Nivelles, Belgium. markus_voges@baxter.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15559489

Citation

Voges, Markus, et al. "Stability of Drug Additives in Peritoneal Dialysis Solutions in a New Container." Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis, vol. 24, no. 6, 2004, pp. 590-5.
Voges M, Faict D, Lechien G, et al. Stability of drug additives in peritoneal dialysis solutions in a new container. Perit Dial Int. 2004;24(6):590-5.
Voges, M., Faict, D., Lechien, G., & Taminne, M. (2004). Stability of drug additives in peritoneal dialysis solutions in a new container. Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis, 24(6), pp. 590-5.
Voges M, et al. Stability of Drug Additives in Peritoneal Dialysis Solutions in a New Container. Perit Dial Int. 2004;24(6):590-5. PubMed PMID: 15559489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of drug additives in peritoneal dialysis solutions in a new container. AU - Voges,Markus, AU - Faict,Dirk, AU - Lechien,Guy, AU - Taminne,Michel, PY - 2004/11/24/pubmed PY - 2005/2/3/medline PY - 2004/11/24/entrez SP - 590 EP - 5 JF - Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis JO - Perit Dial Int VL - 24 IS - 6 N2 - OBJECTIVE: To evaluate the stability of gentamicin, tobramycin, netilmycin, vancomycin, cefazolin, unfractionated heparin, and low molecular weight heparin when added to four different peritoneal dialysis (PD) solutions [Extraneal (Baxter Healthcare, Castlebar, Ireland); Physioneal, Nutrineal, and Dianeal (Baxter Healthcare, Grosotto, Italy)] in new, non-PVC Clear-Flex containers. MEASUREMENTS: Gentamicin, tobramycin, netilmycin, vancomycin, cefazolin, unfractionated heparin, and low molecular weight heparin were injected into separate bags of PD solution. Samples were withdrawn at predefined sampling times and the concentration of each drug was analyzed using high-performance liquid chromatography (for gentamicin, tobramycin, vancomycin, and cefazolin), or bioassay (for netilmycin, gentamicin, and tobramycin in Nutrineal), or coagulation methods (heparins). RESULTS: Netilmycin, vancomycin, cefazolin, and heparin in Physioneal, Nutrineal, Extraneal, and Dianeal were stable for at least 24 hours at 25 degrees C and for an additional 4 hours at 37 degrees C. Gentamicin in Nutrineal, Extraneal, and Dianeal was stable for at least 24 hours at 25 degrees C and for an additional 4 hours at 37 degrees C; gentamicin in Physioneal was stable for less than 24 hours at 25 degrees C. Tobramycin in Nutrineal and Extraneal was stable for at least 24 hours at 25 degrees C and for an additional 4 hours at 37 degrees C; tobramycin in Physioneal and Dianeal was stable for less than 24 hours at 25 degrees C. SN - 0896-8608 UR - https://www.unboundmedicine.com/medline/citation/15559489/Stability_of_drug_additives_in_peritoneal_dialysis_solutions_in_a_new_container_ L2 - http://www.pdiconnect.com/cgi/pmidlookup?view=long&pmid=15559489 DB - PRIME DP - Unbound Medicine ER -