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Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task.
Schizophr Res 2005; 72(2-3):215-24SR

Abstract

Although dorsolateral prefrontal cortex (DLPFC) abnormalities in schizophrenia are well established, several lines of evidence suggest the orbitofrontal cortex (OFC) may also be dysfunctional in this disorder. We examined the performance of schizophrenia patients and nonpatient controls on the Iowa Gambling Task [Cognition 50 (1994) 7], a decision-making task sensitive to OFC damage that involves a series of selections from four decks of cards that vary in their reward/punishment profiles. Patients also completed neuropsychological tests assessing DLPFC functions and clinical symptom assessments. The schizophrenic patients demonstrated a pattern of impaired performance that differed both from healthy controls and from the "non-conservative" pattern typically found in patients with OFC lesions. The patients selected from the two card decks that had low frequency and high magnitude punishments significantly more often than the decks with high frequency and low magnitude punishments. Performance on the task was not strongly related to tests sensitive to DLPFC dysfunction but was correlated with negative symptoms. Results suggest that individuals with schizophrenia display a pattern of compromised decision-making that is somewhat distinct from that found in OFC lesion patients and that may be linked to certain clinical symptoms.

Authors+Show Affiliations

University of California Los Angeles, Neuropsychiatric Institute 300 UCLA Medical Plaza, Los Angeles, CA 90095-6968, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15560966

Citation

Shurman, Brett, et al. "Schizophrenia Patients Demonstrate a Distinctive Pattern of Decision-making Impairment On the Iowa Gambling Task." Schizophrenia Research, vol. 72, no. 2-3, 2005, pp. 215-24.
Shurman B, Horan WP, Nuechterlein KH. Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task. Schizophr Res. 2005;72(2-3):215-24.
Shurman, B., Horan, W. P., & Nuechterlein, K. H. (2005). Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task. Schizophrenia Research, 72(2-3), pp. 215-24.
Shurman B, Horan WP, Nuechterlein KH. Schizophrenia Patients Demonstrate a Distinctive Pattern of Decision-making Impairment On the Iowa Gambling Task. Schizophr Res. 2005 Jan 1;72(2-3):215-24. PubMed PMID: 15560966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task. AU - Shurman,Brett, AU - Horan,William P, AU - Nuechterlein,Keith H, PY - 2003/10/20/received PY - 2004/03/09/revised PY - 2004/03/12/accepted PY - 2004/11/25/pubmed PY - 2005/5/11/medline PY - 2004/11/25/entrez SP - 215 EP - 24 JF - Schizophrenia research JO - Schizophr. Res. VL - 72 IS - 2-3 N2 - Although dorsolateral prefrontal cortex (DLPFC) abnormalities in schizophrenia are well established, several lines of evidence suggest the orbitofrontal cortex (OFC) may also be dysfunctional in this disorder. We examined the performance of schizophrenia patients and nonpatient controls on the Iowa Gambling Task [Cognition 50 (1994) 7], a decision-making task sensitive to OFC damage that involves a series of selections from four decks of cards that vary in their reward/punishment profiles. Patients also completed neuropsychological tests assessing DLPFC functions and clinical symptom assessments. The schizophrenic patients demonstrated a pattern of impaired performance that differed both from healthy controls and from the "non-conservative" pattern typically found in patients with OFC lesions. The patients selected from the two card decks that had low frequency and high magnitude punishments significantly more often than the decks with high frequency and low magnitude punishments. Performance on the task was not strongly related to tests sensitive to DLPFC dysfunction but was correlated with negative symptoms. Results suggest that individuals with schizophrenia display a pattern of compromised decision-making that is somewhat distinct from that found in OFC lesion patients and that may be linked to certain clinical symptoms. SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/15560966/Schizophrenia_patients_demonstrate_a_distinctive_pattern_of_decision_making_impairment_on_the_Iowa_Gambling_Task_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920996404001227 DB - PRIME DP - Unbound Medicine ER -