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Revealing the cause of cryptogenic cirrhosis by posttransplant liver biopsy.
Transplant Proc. 2004 Oct; 36(8):2334-7.TP

Abstract

INTRODUCTION

Because of the tendency for preexisting diseases to recur following liver transplantation, studying the course of patients who were transplanted for their cryptogenic cirrhosis may reveal features of the original cause. We examined the clinicopathological posttransplant progression of patients transplanted due to cryptogenic cirrhosis with emphasis on the detection of posttransplant steatosis and steatohepatitis.

METHODS

The data on all patients transplanted for cryptogenic cirrhosis and their routine 1-year posttransplant liver biopsies were compared to a control group of a randomized sample of patients transplanted for other indications matched for length of follow-up. The posttransplant histological diagnosis was based on the latest available biopsy.

RESULTS

Among 1710 patients, 39 present with cryptogenic etiology survived at least 1 year after transplantation. The control group consisted of 78 patients. The mean ages of the two groups were 50.7 and 49.3 years and the mean follow-up periods 6.2 and 5.7 years, both of which were similar. There was a significantly greater prevalence of posttransplant steatosis and steatohepatitis among the cryptogenic group (37.5 vs 16.7%, P = .048). The difference in patients with at least moderate steatosis was more pronounced (18.8 vs 3.3%, P = .035). Half of these cases progressed to fibrosis and cirrhosis after 48 months.

CONCLUSIONS

This study found a greater incidence of allograft steatosis and steatohepatitis among patients transplanted for cryptogenic cirrhosis compared with a control group. A significant proportion of these patients developed a picture resembling nonalcoholic steatohepatitis, which progressed to fibrosis and cirrhosis.

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Authors+Show Affiliations

Sutedja DS
Singapore Liver Transplant Program, National University Hospital, Singapore. dedess@nuh.com.sg
Gow PJ
No affiliation info available
Hubscher SG
No affiliation info available
Elias E
No affiliation info available

MeSH

AdultBiopsyFatty LiverFemaleFollow-Up StudiesHepatitis, ChronicHumansLiver TransplantationMaleMiddle AgedRetrospective StudiesTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15561241

Citation

Sutedja, D S., et al. "Revealing the Cause of Cryptogenic Cirrhosis By Posttransplant Liver Biopsy." Transplantation Proceedings, vol. 36, no. 8, 2004, pp. 2334-7.
Sutedja DS, Gow PJ, Hubscher SG, et al. Revealing the cause of cryptogenic cirrhosis by posttransplant liver biopsy. Transplant Proc. 2004;36(8):2334-7.
Sutedja, D. S., Gow, P. J., Hubscher, S. G., & Elias, E. (2004). Revealing the cause of cryptogenic cirrhosis by posttransplant liver biopsy. Transplantation Proceedings, 36(8), 2334-7.
Sutedja DS, et al. Revealing the Cause of Cryptogenic Cirrhosis By Posttransplant Liver Biopsy. Transplant Proc. 2004;36(8):2334-7. PubMed PMID: 15561241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Revealing the cause of cryptogenic cirrhosis by posttransplant liver biopsy. AU - Sutedja,D S, AU - Gow,P J, AU - Hubscher,S G, AU - Elias,E, PY - 2004/11/25/pubmed PY - 2005/5/6/medline PY - 2004/11/25/entrez SP - 2334 EP - 7 JF - Transplantation proceedings JO - Transplant. Proc. VL - 36 IS - 8 N2 - INTRODUCTION: Because of the tendency for preexisting diseases to recur following liver transplantation, studying the course of patients who were transplanted for their cryptogenic cirrhosis may reveal features of the original cause. We examined the clinicopathological posttransplant progression of patients transplanted due to cryptogenic cirrhosis with emphasis on the detection of posttransplant steatosis and steatohepatitis. METHODS: The data on all patients transplanted for cryptogenic cirrhosis and their routine 1-year posttransplant liver biopsies were compared to a control group of a randomized sample of patients transplanted for other indications matched for length of follow-up. The posttransplant histological diagnosis was based on the latest available biopsy. RESULTS: Among 1710 patients, 39 present with cryptogenic etiology survived at least 1 year after transplantation. The control group consisted of 78 patients. The mean ages of the two groups were 50.7 and 49.3 years and the mean follow-up periods 6.2 and 5.7 years, both of which were similar. There was a significantly greater prevalence of posttransplant steatosis and steatohepatitis among the cryptogenic group (37.5 vs 16.7%, P = .048). The difference in patients with at least moderate steatosis was more pronounced (18.8 vs 3.3%, P = .035). Half of these cases progressed to fibrosis and cirrhosis after 48 months. CONCLUSIONS: This study found a greater incidence of allograft steatosis and steatohepatitis among patients transplanted for cryptogenic cirrhosis compared with a control group. A significant proportion of these patients developed a picture resembling nonalcoholic steatohepatitis, which progressed to fibrosis and cirrhosis. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/15561241/Revealing_the_cause_of_cryptogenic_cirrhosis_by_posttransplant_liver_biopsy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(04)00785-7 DB - PRIME DP - Unbound Medicine ER -