Tags

Type your tag names separated by a space and hit enter

High-sensitivity C-reactive protein concentration in a healthy Brazilian population.
Int J Cardiol. 2004 Dec; 97(3):433-8.IJ

Abstract

BACKGROUND

The use of serum high-sensitivity C-reactive protein (hs-CRP) for cardiovascular risk profiling requires knowledge of the distribution in different populations. We studied serum hs-CRP in a healthy Brazilian population, with no evidence of heart disease, relative to gender and smoking status as well as other clinical and laboratory variables.

METHODS

684 healthy Brazilian individuals, aged 14-74 years (mean 40.6 years), 295 men (43.1%) and 389 women (56.9%), were enrolled between July 1998 and July 2001. The relationship between the log-transformed hs-CRP, stratified by gender and smoking status (non-smokers, smokers), and clinical and laboratory variables were analyzed using the Spearman correlation coefficient and multiple linear regression.

RESULTS

In a multiple linear regression model age (beta=1.0069, p=0.03), body mass index (BMI) (beta=1.0093, p<0.01), total cholesterol/HDL cholesterol ratio (TC/HDL-C) (beta=1.1015, p<0.01) and heart rate (beta=1.0139, p<0.01) were independently correlated with hs-CRP. Stratification according to gender and smoking was able to disclose different interactions between these variables and hs-CRP. Variables significantly correlated in each stratum were as follows: in smoker men, age (beta=1.0236, p=0.04) and TC/HDL-C (beta=1.2065, p<0.01); in non-smoker men, BMI (beta=1.0786, p<0.01) and TC/HDL-C (beta=1.1397, p=0.01); in smoker women, BMI (beta=1.1006, p=0.03); and in non-smoker women, BMI (beta=1.0873, p<0.01), TC/HDL-C (beta=1.1405, p=0.01) and heart rate (beta=1.0165, p=0.02).

CONCLUSIONS

The clinical and laboratory variables studied influenced the concentration of hs-CRP according to gender and smoking. In assessing the risk of cardiovascular events in relation to serum hs-CRP level, stratification by gender and smoking status is indicated.

Authors+Show Affiliations

Heart Institute (InCor), University of São Paulo Medical School, General Outpatient Clinics, Av. Dr. Enéas de Carvalho Aguiar, 44, 05403-000 São Paulo, SP, Brazil. grafernando@incor.usp.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15561330

Citation

Araújo, Fernando, et al. "High-sensitivity C-reactive Protein Concentration in a Healthy Brazilian Population." International Journal of Cardiology, vol. 97, no. 3, 2004, pp. 433-8.
Araújo F, Pereira AC, Latorre Mdo R, et al. High-sensitivity C-reactive protein concentration in a healthy Brazilian population. Int J Cardiol. 2004;97(3):433-8.
Araújo, F., Pereira, A. C., Latorre, M. d. o. . R., Krieger, J. E., & Mansur, A. J. (2004). High-sensitivity C-reactive protein concentration in a healthy Brazilian population. International Journal of Cardiology, 97(3), 433-8.
Araújo F, et al. High-sensitivity C-reactive Protein Concentration in a Healthy Brazilian Population. Int J Cardiol. 2004;97(3):433-8. PubMed PMID: 15561330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-sensitivity C-reactive protein concentration in a healthy Brazilian population. AU - Araújo,Fernando, AU - Pereira,Alexandre C, AU - Latorre,Maria do Rosário D O, AU - Krieger,José E, AU - Mansur,Alfredo J, PY - 2003/04/23/received PY - 2003/10/09/revised PY - 2003/10/14/accepted PY - 2004/11/25/pubmed PY - 2005/8/17/medline PY - 2004/11/25/entrez SP - 433 EP - 8 JF - International journal of cardiology JO - Int J Cardiol VL - 97 IS - 3 N2 - BACKGROUND: The use of serum high-sensitivity C-reactive protein (hs-CRP) for cardiovascular risk profiling requires knowledge of the distribution in different populations. We studied serum hs-CRP in a healthy Brazilian population, with no evidence of heart disease, relative to gender and smoking status as well as other clinical and laboratory variables. METHODS: 684 healthy Brazilian individuals, aged 14-74 years (mean 40.6 years), 295 men (43.1%) and 389 women (56.9%), were enrolled between July 1998 and July 2001. The relationship between the log-transformed hs-CRP, stratified by gender and smoking status (non-smokers, smokers), and clinical and laboratory variables were analyzed using the Spearman correlation coefficient and multiple linear regression. RESULTS: In a multiple linear regression model age (beta=1.0069, p=0.03), body mass index (BMI) (beta=1.0093, p<0.01), total cholesterol/HDL cholesterol ratio (TC/HDL-C) (beta=1.1015, p<0.01) and heart rate (beta=1.0139, p<0.01) were independently correlated with hs-CRP. Stratification according to gender and smoking was able to disclose different interactions between these variables and hs-CRP. Variables significantly correlated in each stratum were as follows: in smoker men, age (beta=1.0236, p=0.04) and TC/HDL-C (beta=1.2065, p<0.01); in non-smoker men, BMI (beta=1.0786, p<0.01) and TC/HDL-C (beta=1.1397, p=0.01); in smoker women, BMI (beta=1.1006, p=0.03); and in non-smoker women, BMI (beta=1.0873, p<0.01), TC/HDL-C (beta=1.1405, p=0.01) and heart rate (beta=1.0165, p=0.02). CONCLUSIONS: The clinical and laboratory variables studied influenced the concentration of hs-CRP according to gender and smoking. In assessing the risk of cardiovascular events in relation to serum hs-CRP level, stratification by gender and smoking status is indicated. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/15561330/High_sensitivity_C_reactive_protein_concentration_in_a_healthy_Brazilian_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167527304000397 DB - PRIME DP - Unbound Medicine ER -