Tags

Type your tag names separated by a space and hit enter

Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): diagnosis and clinical course.
Best Pract Res Clin Gastroenterol. 2004 Dec; 18(6):1089-104.BP

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a frequent syndrome encompassing fatty liver alone and steatohepatitis (NASH). Often asymptomatic, the suspicion arises because of abnormal aminotransferases or a bright liver on abdominal ultrasound. It should be suspected during evaluation of associated conditions as obesity, diabetes or dyslipidaemia. The diagnostic evaluation must exclude other potential causes of liver disease and may include a liver biopsy, the only method able to confirm features of necroinflammation and fibrosis that define NASH and its prognostic implications. Indeed, the presence of necroinflammation has been associated with a significant risk of progression to cirrhosis and eventually hepatocellular carcinoma. Age >45 years, obesity and diabetes have also been associated with an increased risk of liver fibrosis and progression to cirrhosis. Given the high prevalence of NAFLD, general measures of life-style changes, focusing on exercise, diet, and total alcohol abstinence, should be implemented before a liver biopsy is considered.

Authors+Show Affiliations

Centro de Gastrenterologia, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1649-035 Lisboa, Portugal. hlcortezpinto@netcabo.ptNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15561640

Citation

Cortez-Pinto, Helena, and Maria Ermelinda Camilo. "Non-alcoholic Fatty Liver Disease/non-alcoholic Steatohepatitis (NAFLD/NASH): Diagnosis and Clinical Course." Best Practice & Research. Clinical Gastroenterology, vol. 18, no. 6, 2004, pp. 1089-104.
Cortez-Pinto H, Camilo ME. Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): diagnosis and clinical course. Best Pract Res Clin Gastroenterol. 2004;18(6):1089-104.
Cortez-Pinto, H., & Camilo, M. E. (2004). Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): diagnosis and clinical course. Best Practice & Research. Clinical Gastroenterology, 18(6), 1089-104.
Cortez-Pinto H, Camilo ME. Non-alcoholic Fatty Liver Disease/non-alcoholic Steatohepatitis (NAFLD/NASH): Diagnosis and Clinical Course. Best Pract Res Clin Gastroenterol. 2004;18(6):1089-104. PubMed PMID: 15561640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-alcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH): diagnosis and clinical course. AU - Cortez-Pinto,Helena, AU - Camilo,Maria Ermelinda, PY - 2004/11/25/pubmed PY - 2005/4/27/medline PY - 2004/11/25/entrez SP - 1089 EP - 104 JF - Best practice & research. Clinical gastroenterology JO - Best Pract Res Clin Gastroenterol VL - 18 IS - 6 N2 - Non-alcoholic fatty liver disease (NAFLD) is a frequent syndrome encompassing fatty liver alone and steatohepatitis (NASH). Often asymptomatic, the suspicion arises because of abnormal aminotransferases or a bright liver on abdominal ultrasound. It should be suspected during evaluation of associated conditions as obesity, diabetes or dyslipidaemia. The diagnostic evaluation must exclude other potential causes of liver disease and may include a liver biopsy, the only method able to confirm features of necroinflammation and fibrosis that define NASH and its prognostic implications. Indeed, the presence of necroinflammation has been associated with a significant risk of progression to cirrhosis and eventually hepatocellular carcinoma. Age >45 years, obesity and diabetes have also been associated with an increased risk of liver fibrosis and progression to cirrhosis. Given the high prevalence of NAFLD, general measures of life-style changes, focusing on exercise, diet, and total alcohol abstinence, should be implemented before a liver biopsy is considered. SN - 1521-6918 UR - https://www.unboundmedicine.com/medline/citation/15561640/Non_alcoholic_fatty_liver_disease/non_alcoholic_steatohepatitis__NAFLD/NASH_:_diagnosis_and_clinical_course_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6918(04)00082-4 DB - PRIME DP - Unbound Medicine ER -