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Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors.
Am J Physiol Endocrinol Metab 2005; 288(4):E741-7AJ

Abstract

Adipose tissue is a major source of inflammatory and thrombotic cytokines. This study investigated the relationship of abdominal subcutaneous adipose tissue cytokine gene expression to body composition, fat distribution, and metabolic risk during obesity. We determined body composition, abdominal fat distribution, plasma lipids, and abdominal subcutaneous fat gene expression of leptin, TNF-alpha, IL-6, PAI-1, and adiponectin in 20 obese, middle-aged women (BMI, 32.7 +/- 0.8 kg/m2; age, 57 +/- 1 yr). A subset of these women without diabetes (n = 15) also underwent an OGTT. In all women, visceral fat volume was negatively related to leptin (r = -0.46, P < 0.05) and tended to be negatively related to adiponectin (r = -0.38, P = 0.09) gene expression. Among the nondiabetic women, fasting insulin (r = 0.69, P < 0.01), 2-h insulin (r = 0.56, P < 0.05), and HOMA index (r = 0.59, P < 0.05) correlated positively with TNF-alpha gene expression; fasting insulin (r = 0.54, P < 0.05) was positively related to, and 2-h insulin (r = 0.49, P = 0.06) tended to be positively related to, IL-6 gene expression; and glucose area (r = -0.56, P < 0.05) was negatively related to, and insulin area (r = -0.49, P = 0.06) tended to be negatively related to, adiponectin gene expression. Also, adiponectin gene expression was significantly lower in women with vs. without the metabolic syndrome (adiponectin-beta-actin ratio, 2.26 +/- 0.46 vs. 3.31 +/- 0.33, P < 0.05). We conclude that abdominal subcutaneous adipose tissue expression of inflammatory cytokines is a potential mechanism linking obesity with its metabolic comorbidities.

Authors+Show Affiliations

Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157, USA. tyou@wfubmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15562250

Citation

You, Tongjian, et al. "Abdominal Adipose Tissue Cytokine Gene Expression: Relationship to Obesity and Metabolic Risk Factors." American Journal of Physiology. Endocrinology and Metabolism, vol. 288, no. 4, 2005, pp. E741-7.
You T, Yang R, Lyles MF, et al. Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors. Am J Physiol Endocrinol Metab. 2005;288(4):E741-7.
You, T., Yang, R., Lyles, M. F., Gong, D., & Nicklas, B. J. (2005). Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors. American Journal of Physiology. Endocrinology and Metabolism, 288(4), pp. E741-7.
You T, et al. Abdominal Adipose Tissue Cytokine Gene Expression: Relationship to Obesity and Metabolic Risk Factors. Am J Physiol Endocrinol Metab. 2005;288(4):E741-7. PubMed PMID: 15562250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abdominal adipose tissue cytokine gene expression: relationship to obesity and metabolic risk factors. AU - You,Tongjian, AU - Yang,Rongze, AU - Lyles,Mary F, AU - Gong,Dawei, AU - Nicklas,Barbara J, Y1 - 2004/11/23/ PY - 2004/11/25/pubmed PY - 2005/4/13/medline PY - 2004/11/25/entrez SP - E741 EP - 7 JF - American journal of physiology. Endocrinology and metabolism JO - Am. J. Physiol. Endocrinol. Metab. VL - 288 IS - 4 N2 - Adipose tissue is a major source of inflammatory and thrombotic cytokines. This study investigated the relationship of abdominal subcutaneous adipose tissue cytokine gene expression to body composition, fat distribution, and metabolic risk during obesity. We determined body composition, abdominal fat distribution, plasma lipids, and abdominal subcutaneous fat gene expression of leptin, TNF-alpha, IL-6, PAI-1, and adiponectin in 20 obese, middle-aged women (BMI, 32.7 +/- 0.8 kg/m2; age, 57 +/- 1 yr). A subset of these women without diabetes (n = 15) also underwent an OGTT. In all women, visceral fat volume was negatively related to leptin (r = -0.46, P < 0.05) and tended to be negatively related to adiponectin (r = -0.38, P = 0.09) gene expression. Among the nondiabetic women, fasting insulin (r = 0.69, P < 0.01), 2-h insulin (r = 0.56, P < 0.05), and HOMA index (r = 0.59, P < 0.05) correlated positively with TNF-alpha gene expression; fasting insulin (r = 0.54, P < 0.05) was positively related to, and 2-h insulin (r = 0.49, P = 0.06) tended to be positively related to, IL-6 gene expression; and glucose area (r = -0.56, P < 0.05) was negatively related to, and insulin area (r = -0.49, P = 0.06) tended to be negatively related to, adiponectin gene expression. Also, adiponectin gene expression was significantly lower in women with vs. without the metabolic syndrome (adiponectin-beta-actin ratio, 2.26 +/- 0.46 vs. 3.31 +/- 0.33, P < 0.05). We conclude that abdominal subcutaneous adipose tissue expression of inflammatory cytokines is a potential mechanism linking obesity with its metabolic comorbidities. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/15562250/Abdominal_adipose_tissue_cytokine_gene_expression:_relationship_to_obesity_and_metabolic_risk_factors_ L2 - http://www.physiology.org/doi/full/10.1152/ajpendo.00419.2004?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -