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AD lesions and infarcts in demented and non-demented Japanese-American men.

Abstract

Neocortical neuritic plaques and neurofibrillary tangles are hallmark neuropathological lesions of dementia. Concomitant cerebrovascular lesions increase dementia severity in patients meeting neuropathological criteria for Alzheimer's disease and contribute to cognitive impairment in persons with mild entorhinal Alzheimer lesions. This study investigates whether individuals with sparse neocortical neuritic plaques experience increased odds of crossing the threshold to clinical dementia when they have coexistent cerebrovascular lesions. Dementia examinations were given to 3,734 men during the 1991-1993 Honolulu-Asia Aging Study examination and to 2,603 men during the 1994-1996 examination. Lesion quantification was done without clinical data. Among 333 autopsied men, 120 had dementia, 115 had marginal results, and 98 had normal cognition. In men with neurofibrillary tangles, dementia frequency increased with increasing neuritic plaque density, and increased further in the presence of cerebrovascular lesions. The association was strongest in men with sparse neuritic plaques (1-3/mm(2)) where dementia frequency more than doubled with coexistent cerebrovascular lesions (45 vs 20%). Among all dementia cases, 24% were linked to cerebrovascular lesions. Findings suggest cerebrovascular lesions are associated with a marked excess of dementia in cases with low neuritic plaque frequency. Prevention of cerebrovascular lesions may be critically important in preserving late-life cognitive function.

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  • Authors+Show Affiliations

    ,

    Pacific Health Research Institute, Kuakini Medical Center, University of Hawaii, 846 South Hotel Street, Honolulu, HI 96813, USA. hpetrovitch@phrihawaii.org

    , , , , , , , , , ,

    Source

    Annals of neurology 57:1 2005 Jan pg 98-103

    MeSH

    Aged
    Aged, 80 and over
    Alzheimer Disease
    Asian Americans
    Autopsy
    Cerebral Infarction
    Cohort Studies
    Dementia
    Diagnostic and Statistical Manual of Mental Disorders
    Humans
    Lewy Bodies
    Male
    Neurofibrillary Tangles
    Neuropsychological Tests
    Odds Ratio
    Plaque, Amyloid
    Postmortem Changes
    Prospective Studies
    Retrospective Studies

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, U.S. Gov't, Non-P.H.S.
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15562458

    Citation

    Petrovitch, Helen, et al. "AD Lesions and Infarcts in Demented and Non-demented Japanese-American Men." Annals of Neurology, vol. 57, no. 1, 2005, pp. 98-103.
    Petrovitch H, Ross GW, Steinhorn SC, et al. AD lesions and infarcts in demented and non-demented Japanese-American men. Ann Neurol. 2005;57(1):98-103.
    Petrovitch, H., Ross, G. W., Steinhorn, S. C., Abbott, R. D., Markesbery, W., Davis, D., ... White, L. R. (2005). AD lesions and infarcts in demented and non-demented Japanese-American men. Annals of Neurology, 57(1), pp. 98-103.
    Petrovitch H, et al. AD Lesions and Infarcts in Demented and Non-demented Japanese-American Men. Ann Neurol. 2005;57(1):98-103. PubMed PMID: 15562458.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - AD lesions and infarcts in demented and non-demented Japanese-American men. AU - Petrovitch,Helen, AU - Ross,G Webster, AU - Steinhorn,Sandra C, AU - Abbott,Robert D, AU - Markesbery,William, AU - Davis,Daron, AU - Nelson,James, AU - Hardman,John, AU - Masaki,Kamal, AU - Vogt,Margaret R, AU - Launer,Lenore, AU - White,Lon R, PY - 2004/11/25/pubmed PY - 2005/3/15/medline PY - 2004/11/25/entrez SP - 98 EP - 103 JF - Annals of neurology JO - Ann. Neurol. VL - 57 IS - 1 N2 - Neocortical neuritic plaques and neurofibrillary tangles are hallmark neuropathological lesions of dementia. Concomitant cerebrovascular lesions increase dementia severity in patients meeting neuropathological criteria for Alzheimer's disease and contribute to cognitive impairment in persons with mild entorhinal Alzheimer lesions. This study investigates whether individuals with sparse neocortical neuritic plaques experience increased odds of crossing the threshold to clinical dementia when they have coexistent cerebrovascular lesions. Dementia examinations were given to 3,734 men during the 1991-1993 Honolulu-Asia Aging Study examination and to 2,603 men during the 1994-1996 examination. Lesion quantification was done without clinical data. Among 333 autopsied men, 120 had dementia, 115 had marginal results, and 98 had normal cognition. In men with neurofibrillary tangles, dementia frequency increased with increasing neuritic plaque density, and increased further in the presence of cerebrovascular lesions. The association was strongest in men with sparse neuritic plaques (1-3/mm(2)) where dementia frequency more than doubled with coexistent cerebrovascular lesions (45 vs 20%). Among all dementia cases, 24% were linked to cerebrovascular lesions. Findings suggest cerebrovascular lesions are associated with a marked excess of dementia in cases with low neuritic plaque frequency. Prevention of cerebrovascular lesions may be critically important in preserving late-life cognitive function. SN - 0364-5134 UR - https://www.unboundmedicine.com/medline/citation/15562458/AD_lesions_and_infarcts_in_demented_and_non_demented_Japanese_American_men_ L2 - https://doi.org/10.1002/ana.20318 DB - PRIME DP - Unbound Medicine ER -