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Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities.
J Agric Food Chem. 2004 Dec 01; 52(24):7272-8.JA

Abstract

A preliminary antimicrobial disk assay of chloroform, ethyl acetate, and n-butanol extracts of artichoke (Cynara scolymus L.) leaf extracts showed that the n-butanol fraction exhibited the most significant antimicrobial activities against seven bacteria species, four yeasts, and four molds. Eight phenolic compounds were isolated from the n-butanol soluble fraction of artichoke leaf extracts. On the basis of high-performance liquid chromatography/electrospray ionization mass spectrometry, tandem mass spectrometry, and nuclear magnetic resonance techniques, the structures of the isolated compounds were determined as the four caffeoylquinic acid derivatives, chlorogenic acid (1), cynarin (2), 3,5-di-O-caffeoylquinic acid (3), and 4,5-di-O-caffeoylquinic acid (4), and the four flavonoids, luteolin-7-rutinoside (5), cynaroside (6), apigenin-7-rutinoside (7), and apigenin-7-O-beta-D-glucopyranoside (8), respectively. The isolated compounds were examined for their antimicrobial activities on the above microorganisms, indicating that all eight phenolic compounds showed activity against most of the tested organisms. Among them, chlorogenic acid, cynarin, luteolin-7-rutinoside, and cynaroside exhibited a relatively higher activity than other compounds; in addition, they were more effective against fungi than bacteria. The minimum inhibitory concentrations of these compounds were between 50 and 200 microg/mL.

Authors+Show Affiliations

Research Center for Eco-Environmental Sciences and Graduate School, Chinese Academy of Sciences, P.O. Box 2871, Beijing 100085, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15563206

Citation

Zhu, Xianfeng, et al. "Phenolic Compounds From the Leaf Extract of Artichoke (Cynara Scolymus L.) and Their Antimicrobial Activities." Journal of Agricultural and Food Chemistry, vol. 52, no. 24, 2004, pp. 7272-8.
Zhu X, Zhang H, Lo R. Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities. J Agric Food Chem. 2004;52(24):7272-8.
Zhu, X., Zhang, H., & Lo, R. (2004). Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities. Journal of Agricultural and Food Chemistry, 52(24), 7272-8.
Zhu X, Zhang H, Lo R. Phenolic Compounds From the Leaf Extract of Artichoke (Cynara Scolymus L.) and Their Antimicrobial Activities. J Agric Food Chem. 2004 Dec 1;52(24):7272-8. PubMed PMID: 15563206.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Phenolic compounds from the leaf extract of artichoke (Cynara scolymus L.) and their antimicrobial activities. AU - Zhu,Xianfeng, AU - Zhang,Hongxun, AU - Lo,Raymond, PY - 2004/11/26/pubmed PY - 2004/12/24/medline PY - 2004/11/26/entrez SP - 7272 EP - 8 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 52 IS - 24 N2 - A preliminary antimicrobial disk assay of chloroform, ethyl acetate, and n-butanol extracts of artichoke (Cynara scolymus L.) leaf extracts showed that the n-butanol fraction exhibited the most significant antimicrobial activities against seven bacteria species, four yeasts, and four molds. Eight phenolic compounds were isolated from the n-butanol soluble fraction of artichoke leaf extracts. On the basis of high-performance liquid chromatography/electrospray ionization mass spectrometry, tandem mass spectrometry, and nuclear magnetic resonance techniques, the structures of the isolated compounds were determined as the four caffeoylquinic acid derivatives, chlorogenic acid (1), cynarin (2), 3,5-di-O-caffeoylquinic acid (3), and 4,5-di-O-caffeoylquinic acid (4), and the four flavonoids, luteolin-7-rutinoside (5), cynaroside (6), apigenin-7-rutinoside (7), and apigenin-7-O-beta-D-glucopyranoside (8), respectively. The isolated compounds were examined for their antimicrobial activities on the above microorganisms, indicating that all eight phenolic compounds showed activity against most of the tested organisms. Among them, chlorogenic acid, cynarin, luteolin-7-rutinoside, and cynaroside exhibited a relatively higher activity than other compounds; in addition, they were more effective against fungi than bacteria. The minimum inhibitory concentrations of these compounds were between 50 and 200 microg/mL. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15563206/Phenolic_compounds_from_the_leaf_extract_of_artichoke__Cynara_scolymus_L___and_their_antimicrobial_activities_ DB - PRIME DP - Unbound Medicine ER -