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A case-control study to estimate the impact on breast cancer death of the breast screening programme in Wales.
J Med Screen 2004; 11(4):194-8JM

Abstract

OBJECTIVES

The aim of this study was to estimate the effect of service screening, as provided by the NHS breast screening programme, on breast cancer mortality in Wales. Furthermore, we wished to ascertain whether a reduction in breast cancer mortality consistent with that observed in the randomised screening trials was being achieved.

SETTING

The NHS Breast Screening Programme in Wales, managed by Breast Test Wales, with headquarters in Cardiff.

METHODS

A case-control study design with 1:2 matching. The cases were deaths from breast cancer in women aged 50-75 years at diagnosis who were diagnosed after the instigation of screening in 1991 and who died after 1998. The controls were women who had not died of breast cancer or any other condition during the study period. One was from the same GP practice and the other from a different GP practice within the same district, matched by year of birth.

RESULTS

Based on 419 cases, the odds ratio for risk of death from breast cancer for women who have attended at least one routine screen compared to those never screened was 0.62 (95% confidence interval [CI] 0.47-0.82, p=0.001). After excluding cases diagnosed prior to 1995 and adjusting for self-selection bias, the estimated mortality reduction was 25% (odds ratio=0.75, 95% CI 0.49-1.14, p=0.09).

CONCLUSION

The Breast Test Wales screening programme is achieving a reduction in breast cancer mortality of 25% in women attending for screening, which is consistent with the results of the randomized controlled trials of mammographic screening.

Authors+Show Affiliations

Breast Test Wales, Cardiff, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15563774

Citation

Fielder, H M., et al. "A Case-control Study to Estimate the Impact On Breast Cancer Death of the Breast Screening Programme in Wales." Journal of Medical Screening, vol. 11, no. 4, 2004, pp. 194-8.
Fielder HM, Warwick J, Brook D, et al. A case-control study to estimate the impact on breast cancer death of the breast screening programme in Wales. J Med Screen. 2004;11(4):194-8.
Fielder, H. M., Warwick, J., Brook, D., Gower-Thomas, K., Cuzick, J., Monypenny, I., & Duffy, S. W. (2004). A case-control study to estimate the impact on breast cancer death of the breast screening programme in Wales. Journal of Medical Screening, 11(4), pp. 194-8.
Fielder HM, et al. A Case-control Study to Estimate the Impact On Breast Cancer Death of the Breast Screening Programme in Wales. J Med Screen. 2004;11(4):194-8. PubMed PMID: 15563774.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A case-control study to estimate the impact on breast cancer death of the breast screening programme in Wales. AU - Fielder,H M, AU - Warwick,J, AU - Brook,D, AU - Gower-Thomas,K, AU - Cuzick,J, AU - Monypenny,I, AU - Duffy,S W, PY - 2004/11/27/pubmed PY - 2005/4/22/medline PY - 2004/11/27/entrez SP - 194 EP - 8 JF - Journal of medical screening JO - J Med Screen VL - 11 IS - 4 N2 - OBJECTIVES: The aim of this study was to estimate the effect of service screening, as provided by the NHS breast screening programme, on breast cancer mortality in Wales. Furthermore, we wished to ascertain whether a reduction in breast cancer mortality consistent with that observed in the randomised screening trials was being achieved. SETTING: The NHS Breast Screening Programme in Wales, managed by Breast Test Wales, with headquarters in Cardiff. METHODS: A case-control study design with 1:2 matching. The cases were deaths from breast cancer in women aged 50-75 years at diagnosis who were diagnosed after the instigation of screening in 1991 and who died after 1998. The controls were women who had not died of breast cancer or any other condition during the study period. One was from the same GP practice and the other from a different GP practice within the same district, matched by year of birth. RESULTS: Based on 419 cases, the odds ratio for risk of death from breast cancer for women who have attended at least one routine screen compared to those never screened was 0.62 (95% confidence interval [CI] 0.47-0.82, p=0.001). After excluding cases diagnosed prior to 1995 and adjusting for self-selection bias, the estimated mortality reduction was 25% (odds ratio=0.75, 95% CI 0.49-1.14, p=0.09). CONCLUSION: The Breast Test Wales screening programme is achieving a reduction in breast cancer mortality of 25% in women attending for screening, which is consistent with the results of the randomized controlled trials of mammographic screening. SN - 0969-1413 UR - https://www.unboundmedicine.com/medline/citation/15563774/A_case_control_study_to_estimate_the_impact_on_breast_cancer_death_of_the_breast_screening_programme_in_Wales_ L2 - http://journals.sagepub.com/doi/full/10.1258/0969141042467304?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -