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Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women.
Clin Chim Acta. 2005 Jan; 351(1-2):161-8.CC

Abstract

BACKGROUND

Serum leptin concentration is associated with age, fat and bone mineral density (BMD), and there are ethnic differences in physique and BMD values. The relationship between serum leptin concentration and BMD in Chinese women is presently unknown. We examined the relationship of serum leptin concentration with age, body weight, BMI and BMD in mainland Chinese women.

METHODS

Serum leptin concentration in a population of 676 Chinese females, aged 20-80 years (45.4+/-14.8 years, mean+/-S.D.), was measured using an enzyme-linked immunosorbent assay (ELISA). BMD values were measured by dual-energy X-ray absorptiometry (DXA) at a number of sites: the posteroanterior lumbar spine (PA, L1-L4), lateral lumbar spine (Lat, L2-L4), hip (including the femoral neck (FN) and total hip (T-hip)), and forearm (one-third region (RU1/3) and total region (RUT)). The relationship between changes in serum leptin concentration with age, body weight, height, body mass index (BMI) and BMD values at six sites were analyzed using 10 different regression models, and the models giving the best fit were selected.

RESULTS

The cubic regression model best described the changes in serum leptin concentration with age (R(2)=0.048, p<0.001) and body weight (R(2)=0.352, p<0.001), while the quadratic regression model was best for serum leptin concentration changes with BMI (R(2)=0.410, p<0.001); serum leptin concentration was not correlated with height. Serum leptin concentration was significantly higher in postmenopausal than premenopausal women (p<0.001). Serum leptin concentration was correlated with Lat BMD (R(2)=0.012, p<0.018), FN BMD (R(2)=0.006, p<0.041) and T-hip BMD (R(2)=0.013, p<0.004) in the whole population. In premenopausal women, leptin was positively associated with BMD except for Lat (R(2)=0.029-0.055, p<0.008); in postmenopausal women, leptin was also positively associated with AP, FN, T-hip BMD (R(2)=0.026-0.042, p<0.007). However, after adjusting for BMI not for body weight, there was no association between serum leptin concentration and age. Meanwhile, after adjustment for age, body weight and BMI, there was no association between serum leptin concentration and BMD values in premenopausal and postmenopausal women.

CONCLUSIONS

Age-related changes in serum leptin concentration is dependent on BMI, but not a direct determinant of BMD in Chinese females.

Authors+Show Affiliations

Institute of Endocrinology and Metabolism, the Second Xiang-Ya Hospital, Central South University, Changsha, 86 Renmin-Zhong Rd, Hunan 410011, P.R. China. zhongni1111@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15563886

Citation

Zhong, Ni, et al. "Relationship of Serum Leptin With Age, Body Weight, Body Mass Index, and Bone Mineral Density in Healthy Mainland Chinese Women." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 351, no. 1-2, 2005, pp. 161-8.
Zhong N, Wu XP, Xu ZR, et al. Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clin Chim Acta. 2005;351(1-2):161-8.
Zhong, N., Wu, X. P., Xu, Z. R., Wang, A. H., Luo, X. H., Cao, X. Z., Xie, H., Shan, P. F., & Liao, E. Y. (2005). Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. Clinica Chimica Acta; International Journal of Clinical Chemistry, 351(1-2), 161-8.
Zhong N, et al. Relationship of Serum Leptin With Age, Body Weight, Body Mass Index, and Bone Mineral Density in Healthy Mainland Chinese Women. Clin Chim Acta. 2005;351(1-2):161-8. PubMed PMID: 15563886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of serum leptin with age, body weight, body mass index, and bone mineral density in healthy mainland Chinese women. AU - Zhong,Ni, AU - Wu,Xian-Ping, AU - Xu,Zhang-Rong, AU - Wang,Ai-Hong, AU - Luo,Xiang-Hang, AU - Cao,Xing-Zhi, AU - Xie,Hui, AU - Shan,Peng-Fei, AU - Liao,Er-Yuan, PY - 2004/07/02/received PY - 2004/09/07/revised PY - 2004/09/07/accepted PY - 2004/11/27/pubmed PY - 2005/4/19/medline PY - 2004/11/27/entrez SP - 161 EP - 8 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 351 IS - 1-2 N2 - BACKGROUND: Serum leptin concentration is associated with age, fat and bone mineral density (BMD), and there are ethnic differences in physique and BMD values. The relationship between serum leptin concentration and BMD in Chinese women is presently unknown. We examined the relationship of serum leptin concentration with age, body weight, BMI and BMD in mainland Chinese women. METHODS: Serum leptin concentration in a population of 676 Chinese females, aged 20-80 years (45.4+/-14.8 years, mean+/-S.D.), was measured using an enzyme-linked immunosorbent assay (ELISA). BMD values were measured by dual-energy X-ray absorptiometry (DXA) at a number of sites: the posteroanterior lumbar spine (PA, L1-L4), lateral lumbar spine (Lat, L2-L4), hip (including the femoral neck (FN) and total hip (T-hip)), and forearm (one-third region (RU1/3) and total region (RUT)). The relationship between changes in serum leptin concentration with age, body weight, height, body mass index (BMI) and BMD values at six sites were analyzed using 10 different regression models, and the models giving the best fit were selected. RESULTS: The cubic regression model best described the changes in serum leptin concentration with age (R(2)=0.048, p<0.001) and body weight (R(2)=0.352, p<0.001), while the quadratic regression model was best for serum leptin concentration changes with BMI (R(2)=0.410, p<0.001); serum leptin concentration was not correlated with height. Serum leptin concentration was significantly higher in postmenopausal than premenopausal women (p<0.001). Serum leptin concentration was correlated with Lat BMD (R(2)=0.012, p<0.018), FN BMD (R(2)=0.006, p<0.041) and T-hip BMD (R(2)=0.013, p<0.004) in the whole population. In premenopausal women, leptin was positively associated with BMD except for Lat (R(2)=0.029-0.055, p<0.008); in postmenopausal women, leptin was also positively associated with AP, FN, T-hip BMD (R(2)=0.026-0.042, p<0.007). However, after adjusting for BMI not for body weight, there was no association between serum leptin concentration and age. Meanwhile, after adjustment for age, body weight and BMI, there was no association between serum leptin concentration and BMD values in premenopausal and postmenopausal women. CONCLUSIONS: Age-related changes in serum leptin concentration is dependent on BMI, but not a direct determinant of BMD in Chinese females. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/15563886/Relationship_of_serum_leptin_with_age_body_weight_body_mass_index_and_bone_mineral_density_in_healthy_mainland_Chinese_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(04)00431-0 DB - PRIME DP - Unbound Medicine ER -