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Psychosocial factors and the response to influenza vaccination in older adults.
Psychosom Med. 2004 Nov-Dec; 66(6):950-3.PM

Abstract

OBJECTIVE

We examined the influence of psychological state (depression, negative affect, perceived stress) and social support on pre- and post-vaccination response to influenza vaccine.

METHODS

Venous blood was drawn from 37 nursing home residents before and following injection of the trivalent influenza vaccine (comprised of the New Caledonia (NC), Hong Kong (HK), and Panama (Pan) strains of flu). The Geriatric Depression Scale, Perceived Stress Scale, Positive and Negative Affect Schedule, and Multidimensional Scale of Perceived Social Support were completed following the initial blood draw.

RESULTS

Social support and perceived stress were correlated with pre-vaccine antibody responses to two of the three vaccine components (HK and NC). Social support was negatively correlated with both pre- and post-vaccine titers to Pan. Depression, positive affect, and negative affect were not related to vaccine response.

CONCLUSIONS

Perceived stress and social support influence the rate of decline of antibody titers to previous exposures to some strains of influenza occurring either naturally or via deliberate vaccination.

Authors+Show Affiliations

Moynihan JA
Department of Psychiatry, University of Rochester Medical Center, Box PSYCH, 300 Crittenden Blvd., Rochester, NY 14642, USA. jan_moynihan@urmc.rochester.edu
Larson MR
No affiliation info available
Treanor J
No affiliation info available
Duberstein PR
No affiliation info available
Power A
No affiliation info available
Shore B
No affiliation info available
Ader R
No affiliation info available

MeSH

AffectAge FactorsAgedAged, 80 and overAntibodies, ViralAntibody FormationFemaleGeriatric AssessmentHumansInfluenza A virusInfluenza VaccinesInfluenza, HumanMaleMass VaccinationNursing HomesOrthomyxoviridaePsychiatric Status Rating ScalesSocial SupportStress, PsychologicalVaccination

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15564363

Clinical Trial Links

Flu and Mood in Older Adults

Citation

Moynihan, Jan A., et al. "Psychosocial Factors and the Response to Influenza Vaccination in Older Adults." Psychosomatic Medicine, vol. 66, no. 6, 2004, pp. 950-3.
Moynihan JA, Larson MR, Treanor J, et al. Psychosocial factors and the response to influenza vaccination in older adults. Psychosom Med. 2004;66(6):950-3.
Moynihan, J. A., Larson, M. R., Treanor, J., Duberstein, P. R., Power, A., Shore, B., & Ader, R. (2004). Psychosocial factors and the response to influenza vaccination in older adults. Psychosomatic Medicine, 66(6), 950-3.
Moynihan JA, et al. Psychosocial Factors and the Response to Influenza Vaccination in Older Adults. Psychosom Med. 2004 Nov-Dec;66(6):950-3. PubMed PMID: 15564363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychosocial factors and the response to influenza vaccination in older adults. AU - Moynihan,Jan A, AU - Larson,Mark R, AU - Treanor,John, AU - Duberstein,Paul R, AU - Power,Alan, AU - Shore,Bernard, AU - Ader,Robert, PY - 2004/11/27/pubmed PY - 2005/9/1/medline PY - 2004/11/27/entrez SP - 950 EP - 3 JF - Psychosomatic medicine JO - Psychosom Med VL - 66 IS - 6 N2 - OBJECTIVE: We examined the influence of psychological state (depression, negative affect, perceived stress) and social support on pre- and post-vaccination response to influenza vaccine. METHODS: Venous blood was drawn from 37 nursing home residents before and following injection of the trivalent influenza vaccine (comprised of the New Caledonia (NC), Hong Kong (HK), and Panama (Pan) strains of flu). The Geriatric Depression Scale, Perceived Stress Scale, Positive and Negative Affect Schedule, and Multidimensional Scale of Perceived Social Support were completed following the initial blood draw. RESULTS: Social support and perceived stress were correlated with pre-vaccine antibody responses to two of the three vaccine components (HK and NC). Social support was negatively correlated with both pre- and post-vaccine titers to Pan. Depression, positive affect, and negative affect were not related to vaccine response. CONCLUSIONS: Perceived stress and social support influence the rate of decline of antibody titers to previous exposures to some strains of influenza occurring either naturally or via deliberate vaccination. SN - 1534-7796 UR - https://www.unboundmedicine.com/medline/citation/15564363/Psychosocial_factors_and_the_response_to_influenza_vaccination_in_older_adults_ DB - PRIME DP - Unbound Medicine ER -