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[Clinical significance of human telomerase reverse transcriptase in patients with colon cancer].
Ai Zheng. 2004 Nov; 23(11 Suppl):1502-7.AZ

Abstract

BACKGROUND & OBJECTIVE

Although telomerase activity can be detected in 70%-90% malignant tumor tissues, it is still a controversial prognostic factor of patients with malignant tumors. This study was to evaluate clinical significance of human telomerase reverse transcriptase (hTERT) in patients with colon cancer.

METHODS

Expression of hTERT in 59 matched pairs of tumor and adjacent non-tumorous mucosa samples from patients with colon cancer who underwent complete resection were measured by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR).

RESULTS

Expression of hTERT in both tumor samples and nontumorous mucosa samples has no significant correlation with clinicopathologic factors. Of 32 patients with colon cancer of Dukes' A, and B stages, prognosis of 18 (56%) patients with hTERT expression of lower than 0.60 in tumor tissue was better than that of 27 (44%) patients with hTERT expression of higher than 0.60 (P=0.006), prognosis of 20 (62%) patients with the value of hTERT expression in tumor tissue subtracted from that in matched non-tumorous tissue below 0.50 was better than that of 12 (38%) patients with that value above 0.50 (P=0.035). In 27 patients with colon cancer of Dukes' C, and D stages, it was not practical to estimate the patients' prognosis with hTERT expression level in tumor tissue and the expression difference between tumor tissue and non-tumorous tissue.

CONCLUSION

hTERT expression may be a potential prognostic index for patients with colon cancer of Dukes' A, and B stages.

Authors+Show Affiliations

Department of Hematology Oncology, The Queen Elizabeth Hospital, Woodville Road, SA Australia 5011.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15566667

Citation

Li, Li-Ren, et al. "[Clinical Significance of Human Telomerase Reverse Transcriptase in Patients With Colon Cancer]." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 23, no. 11 Suppl, 2004, pp. 1502-7.
Li LR, Wan DS, Pan ZZ, et al. [Clinical significance of human telomerase reverse transcriptase in patients with colon cancer]. Ai Zheng. 2004;23(11 Suppl):1502-7.
Li, L. R., Wan, D. S., Pan, Z. Z., Hardingham, J., Rieger, N., Hewett, P., Zhou, Z. W., & Chen, G. (2004). [Clinical significance of human telomerase reverse transcriptase in patients with colon cancer]. Ai Zheng = Aizheng = Chinese Journal of Cancer, 23(11 Suppl), 1502-7.
Li LR, et al. [Clinical Significance of Human Telomerase Reverse Transcriptase in Patients With Colon Cancer]. Ai Zheng. 2004;23(11 Suppl):1502-7. PubMed PMID: 15566667.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical significance of human telomerase reverse transcriptase in patients with colon cancer]. AU - Li,Li-Ren, AU - Wan,De-Sen, AU - Pan,Zhi-Zhong, AU - Hardingham,Jenny, AU - Rieger,Nick, AU - Hewett,Peter, AU - Zhou,Zhi-Wei, AU - Chen,Gong, PY - 2004/11/30/pubmed PY - 2005/8/6/medline PY - 2004/11/30/entrez SP - 1502 EP - 7 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 23 IS - 11 Suppl N2 - BACKGROUND & OBJECTIVE: Although telomerase activity can be detected in 70%-90% malignant tumor tissues, it is still a controversial prognostic factor of patients with malignant tumors. This study was to evaluate clinical significance of human telomerase reverse transcriptase (hTERT) in patients with colon cancer. METHODS: Expression of hTERT in 59 matched pairs of tumor and adjacent non-tumorous mucosa samples from patients with colon cancer who underwent complete resection were measured by quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: Expression of hTERT in both tumor samples and nontumorous mucosa samples has no significant correlation with clinicopathologic factors. Of 32 patients with colon cancer of Dukes' A, and B stages, prognosis of 18 (56%) patients with hTERT expression of lower than 0.60 in tumor tissue was better than that of 27 (44%) patients with hTERT expression of higher than 0.60 (P=0.006), prognosis of 20 (62%) patients with the value of hTERT expression in tumor tissue subtracted from that in matched non-tumorous tissue below 0.50 was better than that of 12 (38%) patients with that value above 0.50 (P=0.035). In 27 patients with colon cancer of Dukes' C, and D stages, it was not practical to estimate the patients' prognosis with hTERT expression level in tumor tissue and the expression difference between tumor tissue and non-tumorous tissue. CONCLUSION: hTERT expression may be a potential prognostic index for patients with colon cancer of Dukes' A, and B stages. UR - https://www.unboundmedicine.com/medline/citation/15566667/[Clinical_significance_of_human_telomerase_reverse_transcriptase_in_patients_with_colon_cancer]_ L2 - http://www.cancercommun.com/fulltextnew.asp?y=2004&m=11 Suppl&ym=1502 DB - PRIME DP - Unbound Medicine ER -