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Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats.
Neuropharmacology 2004; 47(8):1170-9N

Abstract

Cannabinoid receptors in the brain (CB(1)) take part in modulation of learning, and are particularly important for working and short-term memory. Here, we employed a delayed-matching-to-place (DMTP) task in the open-field water maze and examined the effects of cannabis plant extracts rich in either Delta(9)-tetrahydrocannabinol (Delta(9)-THC), or rich in cannabidiol (CBD), on spatial working and short-term memory formation in rats. Delta(9)-THC-rich extracts impaired performance in the memory trial (trial 2) of the DMTP task in a dose-dependent but delay-independent manner. Deficits appeared at doses of 2 or 5 mg/kg (i.p.) at both 30 s and 4 h delays and were similar in severity compared with synthetic Delta(9)-THC. Despite considerable amounts of Delta(9)-THC present, CBD-rich extracts had no effect on spatial working/short-term memory, even at doses of up to 50 mg/kg. When given concomitantly, CBD-rich extracts did not reverse memory deficits of the additional Delta(9)-THC-rich extract. CBD-rich extracts also did not alter Delta(9)-THC-rich extract-induced catalepsy as revealed by the bar test. It appears that spatial working/short-term memory is not sensitive to CBD-rich extracts and that potentiation and antagonism of Delta(9)-THC-induced spatial memory deficits is dependent on the ratio between CBD and Delta(9)-THC.

Authors+Show Affiliations

Department of Biomedical Science, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15567426

Citation

Fadda, Paola, et al. "Differential Effects of THC- or CBD-rich Cannabis Extracts On Working Memory in Rats." Neuropharmacology, vol. 47, no. 8, 2004, pp. 1170-9.
Fadda P, Robinson L, Fratta W, et al. Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. Neuropharmacology. 2004;47(8):1170-9.
Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G., & Riedel, G. (2004). Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. Neuropharmacology, 47(8), pp. 1170-9.
Fadda P, et al. Differential Effects of THC- or CBD-rich Cannabis Extracts On Working Memory in Rats. Neuropharmacology. 2004;47(8):1170-9. PubMed PMID: 15567426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. AU - Fadda,Paola, AU - Robinson,Lianne, AU - Fratta,Walter, AU - Pertwee,Roger G, AU - Riedel,Gernot, PY - 2004/04/22/received PY - 2004/06/29/revised PY - 2004/08/17/accepted PY - 2004/11/30/pubmed PY - 2005/2/11/medline PY - 2004/11/30/entrez SP - 1170 EP - 9 JF - Neuropharmacology JO - Neuropharmacology VL - 47 IS - 8 N2 - Cannabinoid receptors in the brain (CB(1)) take part in modulation of learning, and are particularly important for working and short-term memory. Here, we employed a delayed-matching-to-place (DMTP) task in the open-field water maze and examined the effects of cannabis plant extracts rich in either Delta(9)-tetrahydrocannabinol (Delta(9)-THC), or rich in cannabidiol (CBD), on spatial working and short-term memory formation in rats. Delta(9)-THC-rich extracts impaired performance in the memory trial (trial 2) of the DMTP task in a dose-dependent but delay-independent manner. Deficits appeared at doses of 2 or 5 mg/kg (i.p.) at both 30 s and 4 h delays and were similar in severity compared with synthetic Delta(9)-THC. Despite considerable amounts of Delta(9)-THC present, CBD-rich extracts had no effect on spatial working/short-term memory, even at doses of up to 50 mg/kg. When given concomitantly, CBD-rich extracts did not reverse memory deficits of the additional Delta(9)-THC-rich extract. CBD-rich extracts also did not alter Delta(9)-THC-rich extract-induced catalepsy as revealed by the bar test. It appears that spatial working/short-term memory is not sensitive to CBD-rich extracts and that potentiation and antagonism of Delta(9)-THC-induced spatial memory deficits is dependent on the ratio between CBD and Delta(9)-THC. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/15567426/Differential_effects_of_THC__or_CBD_rich_cannabis_extracts_on_working_memory_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028390804002564 DB - PRIME DP - Unbound Medicine ER -