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Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats.
Neuropharmacology 2004; 47(8):1170-9N

Abstract

Cannabinoid receptors in the brain (CB(1)) take part in modulation of learning, and are particularly important for working and short-term memory. Here, we employed a delayed-matching-to-place (DMTP) task in the open-field water maze and examined the effects of cannabis plant extracts rich in either Delta(9)-tetrahydrocannabinol (Delta(9)-THC), or rich in cannabidiol (CBD), on spatial working and short-term memory formation in rats. Delta(9)-THC-rich extracts impaired performance in the memory trial (trial 2) of the DMTP task in a dose-dependent but delay-independent manner. Deficits appeared at doses of 2 or 5 mg/kg (i.p.) at both 30 s and 4 h delays and were similar in severity compared with synthetic Delta(9)-THC. Despite considerable amounts of Delta(9)-THC present, CBD-rich extracts had no effect on spatial working/short-term memory, even at doses of up to 50 mg/kg. When given concomitantly, CBD-rich extracts did not reverse memory deficits of the additional Delta(9)-THC-rich extract. CBD-rich extracts also did not alter Delta(9)-THC-rich extract-induced catalepsy as revealed by the bar test. It appears that spatial working/short-term memory is not sensitive to CBD-rich extracts and that potentiation and antagonism of Delta(9)-THC-induced spatial memory deficits is dependent on the ratio between CBD and Delta(9)-THC.

Authors+Show Affiliations

Department of Biomedical Science, College of Life Sciences and Medicine, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15567426

Citation

Fadda, Paola, et al. "Differential Effects of THC- or CBD-rich Cannabis Extracts On Working Memory in Rats." Neuropharmacology, vol. 47, no. 8, 2004, pp. 1170-9.
Fadda P, Robinson L, Fratta W, et al. Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. Neuropharmacology. 2004;47(8):1170-9.
Fadda, P., Robinson, L., Fratta, W., Pertwee, R. G., & Riedel, G. (2004). Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. Neuropharmacology, 47(8), pp. 1170-9.
Fadda P, et al. Differential Effects of THC- or CBD-rich Cannabis Extracts On Working Memory in Rats. Neuropharmacology. 2004;47(8):1170-9. PubMed PMID: 15567426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential effects of THC- or CBD-rich cannabis extracts on working memory in rats. AU - Fadda,Paola, AU - Robinson,Lianne, AU - Fratta,Walter, AU - Pertwee,Roger G, AU - Riedel,Gernot, PY - 2004/04/22/received PY - 2004/06/29/revised PY - 2004/08/17/accepted PY - 2004/11/30/pubmed PY - 2005/2/11/medline PY - 2004/11/30/entrez SP - 1170 EP - 9 JF - Neuropharmacology JO - Neuropharmacology VL - 47 IS - 8 N2 - Cannabinoid receptors in the brain (CB(1)) take part in modulation of learning, and are particularly important for working and short-term memory. Here, we employed a delayed-matching-to-place (DMTP) task in the open-field water maze and examined the effects of cannabis plant extracts rich in either Delta(9)-tetrahydrocannabinol (Delta(9)-THC), or rich in cannabidiol (CBD), on spatial working and short-term memory formation in rats. Delta(9)-THC-rich extracts impaired performance in the memory trial (trial 2) of the DMTP task in a dose-dependent but delay-independent manner. Deficits appeared at doses of 2 or 5 mg/kg (i.p.) at both 30 s and 4 h delays and were similar in severity compared with synthetic Delta(9)-THC. Despite considerable amounts of Delta(9)-THC present, CBD-rich extracts had no effect on spatial working/short-term memory, even at doses of up to 50 mg/kg. When given concomitantly, CBD-rich extracts did not reverse memory deficits of the additional Delta(9)-THC-rich extract. CBD-rich extracts also did not alter Delta(9)-THC-rich extract-induced catalepsy as revealed by the bar test. It appears that spatial working/short-term memory is not sensitive to CBD-rich extracts and that potentiation and antagonism of Delta(9)-THC-induced spatial memory deficits is dependent on the ratio between CBD and Delta(9)-THC. SN - 0028-3908 UR - https://www.unboundmedicine.com/medline/citation/15567426/Differential_effects_of_THC__or_CBD_rich_cannabis_extracts_on_working_memory_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028390804002564 DB - PRIME DP - Unbound Medicine ER -