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Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in the dog.
JPEN J Parenter Enteral Nutr. 1992 Mar-Apr; 16(2):117-21.JJ

Abstract

Glutamine is a nonessential neutral amino acid that is widely consumed by the intestinal tract in catabolic states. We have followed up the plasma amino acid profile after extensive small-bowel resection in dogs receiving total parenteral nutrition (TPN) with or without glutamine (GLN) or N-acetylglutamine (aGLN) supplementation. Animals were divided into four groups according to the type of surgery (enterectomy or transection) and nutrition (TPN, TPN with aGLN, or TPN with GLN). Plasma GLN levels decreased in group I (enterectomy and TPN) on day 2 (p = .03) and significantly increased on postoperative days in groups III (enterectomy and TPN with aGLN) and IV (enterectomy and TPN with GLN). A significant increase of plasma GLN was observed in groups III and IV compared with group I on days 6 and 8 (p = .03 and p = .01). Plasma alanine decreased in groups with bowel resection, whereas no change was observed in the control group (transection) and the decrease of plasma alanine was significantly less pronounced in groups III and IV compared with group I. The increase of crypt depth and villous height was more pronounced in groups III and IV. These results suggest that GLN is a required substrate for mucosal growth and function, which could improve the intestinal adaptation encountered after enterectomy.

Authors+Show Affiliations

Laboratory of Nutrition and Experimental Oncology, Cancer Institute, Monpellier, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1556804

Citation

Gouttebel, M C., et al. "Influence of N-acetylglutamine or Glutamine Infusion On Plasma Amino Acid Concentrations During the Early Phase of Small-bowel Adaptation in the Dog." JPEN. Journal of Parenteral and Enteral Nutrition, vol. 16, no. 2, 1992, pp. 117-21.
Gouttebel MC, Astre C, Briand D, et al. Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in the dog. JPEN J Parenter Enteral Nutr. 1992;16(2):117-21.
Gouttebel, M. C., Astre, C., Briand, D., Saint-Aubert, B., Girardot, P. M., & Joyeux, H. (1992). Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in the dog. JPEN. Journal of Parenteral and Enteral Nutrition, 16(2), 117-21.
Gouttebel MC, et al. Influence of N-acetylglutamine or Glutamine Infusion On Plasma Amino Acid Concentrations During the Early Phase of Small-bowel Adaptation in the Dog. JPEN J Parenter Enteral Nutr. 1992 Mar-Apr;16(2):117-21. PubMed PMID: 1556804.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in the dog. AU - Gouttebel,M C, AU - Astre,C, AU - Briand,D, AU - Saint-Aubert,B, AU - Girardot,P M, AU - Joyeux,H, PY - 1992/3/1/pubmed PY - 1992/3/1/medline PY - 1992/3/1/entrez SP - 117 EP - 21 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 16 IS - 2 N2 - Glutamine is a nonessential neutral amino acid that is widely consumed by the intestinal tract in catabolic states. We have followed up the plasma amino acid profile after extensive small-bowel resection in dogs receiving total parenteral nutrition (TPN) with or without glutamine (GLN) or N-acetylglutamine (aGLN) supplementation. Animals were divided into four groups according to the type of surgery (enterectomy or transection) and nutrition (TPN, TPN with aGLN, or TPN with GLN). Plasma GLN levels decreased in group I (enterectomy and TPN) on day 2 (p = .03) and significantly increased on postoperative days in groups III (enterectomy and TPN with aGLN) and IV (enterectomy and TPN with GLN). A significant increase of plasma GLN was observed in groups III and IV compared with group I on days 6 and 8 (p = .03 and p = .01). Plasma alanine decreased in groups with bowel resection, whereas no change was observed in the control group (transection) and the decrease of plasma alanine was significantly less pronounced in groups III and IV compared with group I. The increase of crypt depth and villous height was more pronounced in groups III and IV. These results suggest that GLN is a required substrate for mucosal growth and function, which could improve the intestinal adaptation encountered after enterectomy. SN - 0148-6071 UR - https://www.unboundmedicine.com/medline/citation/1556804/Influence_of_N_acetylglutamine_or_glutamine_infusion_on_plasma_amino_acid_concentrations_during_the_early_phase_of_small_bowel_adaptation_in_the_dog_ L2 - https://doi.org/10.1177/0148607192016002117 DB - PRIME DP - Unbound Medicine ER -