Tags

Type your tag names separated by a space and hit enter

The reactivity of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in alcoholic solutions.
J Forensic Sci. 2004 Nov; 49(6):1220-9.JF

Abstract

In this work the stability of GBL (gamma-butyrolactone) and GHB (gamma-hydroxybutyric acid) in alcoholic media was studied. Under acidic conditions the GBL will react with ethanol or methanol to give the corresponding ethyl and methyl esters of GHB. It can be seen that ester formation is dependent on the type of alcohol, the alcohol content of the solution, and the pH of the solution. Under the same conditions it was shown that GHB does not give rise directly to the corresponding ester when merely in the presence of an alcohol; however the ester will be formed if the conditions are present for conversion of GHB to GBL followed by subsequent reaction with alcohol. In alcoholic beverage samples spiked with GBL the expected conversion to GHB occurred, and the formation of the ethyl ester of GHB was also seen in some samples. Wine samples were analyzed for the presence of the ethyl ester of GHB, and the effect of adding GHB/GBL to hot beverages was studied.

Authors+Show Affiliations

Department of Applied Sciences, Limerick Institute of Technology, Moylish, Limerick, Ireland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15568693

Citation

Hennessy, Sinead A., et al. "The Reactivity of Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) in Alcoholic Solutions." Journal of Forensic Sciences, vol. 49, no. 6, 2004, pp. 1220-9.
Hennessy SA, Moane SM, McDermott SD. The reactivity of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in alcoholic solutions. J Forensic Sci. 2004;49(6):1220-9.
Hennessy, S. A., Moane, S. M., & McDermott, S. D. (2004). The reactivity of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in alcoholic solutions. Journal of Forensic Sciences, 49(6), 1220-9.
Hennessy SA, Moane SM, McDermott SD. The Reactivity of Gamma-hydroxybutyric Acid (GHB) and Gamma-butyrolactone (GBL) in Alcoholic Solutions. J Forensic Sci. 2004;49(6):1220-9. PubMed PMID: 15568693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The reactivity of gamma-hydroxybutyric acid (GHB) and gamma-butyrolactone (GBL) in alcoholic solutions. AU - Hennessy,Sinead A, AU - Moane,Siobhán M, AU - McDermott,Seán D, PY - 2004/12/1/pubmed PY - 2005/1/22/medline PY - 2004/12/1/entrez SP - 1220 EP - 9 JF - Journal of forensic sciences JO - J Forensic Sci VL - 49 IS - 6 N2 - In this work the stability of GBL (gamma-butyrolactone) and GHB (gamma-hydroxybutyric acid) in alcoholic media was studied. Under acidic conditions the GBL will react with ethanol or methanol to give the corresponding ethyl and methyl esters of GHB. It can be seen that ester formation is dependent on the type of alcohol, the alcohol content of the solution, and the pH of the solution. Under the same conditions it was shown that GHB does not give rise directly to the corresponding ester when merely in the presence of an alcohol; however the ester will be formed if the conditions are present for conversion of GHB to GBL followed by subsequent reaction with alcohol. In alcoholic beverage samples spiked with GBL the expected conversion to GHB occurred, and the formation of the ethyl ester of GHB was also seen in some samples. Wine samples were analyzed for the presence of the ethyl ester of GHB, and the effect of adding GHB/GBL to hot beverages was studied. SN - 0022-1198 UR - https://www.unboundmedicine.com/medline/citation/15568693/The_reactivity_of_gamma_hydroxybutyric_acid__GHB__and_gamma_butyrolactone__GBL__in_alcoholic_solutions_ L2 - https://medlineplus.gov/clubdrugs.html DB - PRIME DP - Unbound Medicine ER -