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Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens.
J Nat Prod. 2004 Nov; 67(11):1829-32.JN

Abstract

Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay.

Authors+Show Affiliations

Laboratory of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B-9000 Ghent, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15568770

Citation

De Naeyer, An, et al. "Estrogenic and Anticarcinogenic Properties of Kurarinone, a Lavandulyl Flavanone From the Roots of Sophora Flavescens." Journal of Natural Products, vol. 67, no. 11, 2004, pp. 1829-32.
De Naeyer A, Vanden Berghe W, Pocock V, et al. Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. J Nat Prod. 2004;67(11):1829-32.
De Naeyer, A., Vanden Berghe, W., Pocock, V., Milligan, S., Haegeman, G., & De Keukeleire, D. (2004). Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. Journal of Natural Products, 67(11), 1829-32.
De Naeyer A, et al. Estrogenic and Anticarcinogenic Properties of Kurarinone, a Lavandulyl Flavanone From the Roots of Sophora Flavescens. J Nat Prod. 2004;67(11):1829-32. PubMed PMID: 15568770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estrogenic and anticarcinogenic properties of kurarinone, a lavandulyl flavanone from the roots of Sophora flavescens. AU - De Naeyer,An, AU - Vanden Berghe,Wim, AU - Pocock,Victoria, AU - Milligan,Stuart, AU - Haegeman,Guy, AU - De Keukeleire,Denis, PY - 2004/12/1/pubmed PY - 2005/1/20/medline PY - 2004/12/1/entrez SP - 1829 EP - 32 JF - Journal of natural products JO - J Nat Prod VL - 67 IS - 11 N2 - Kurarinone, a lavandulyl flavanone, was isolated from a polyphenolic extract of the roots of Sophora flavescens using fractionation guided by estrogenic activity, which was determined by recombinant yeast and Ishikawa Var-I bioassays. Kurarinone showed weak estrogenic activity both in the yeast screen and in the Ishikawa Var-I assay with EC(50) values of 4.6 and 1.66 microM, respectively. Furthermore, kurarinone was found to have potent cytotoxic activity (IC(50) value = 22.2 microM) against human MCF-7/6 breast cancer cells in the sulforhodamine-B assay. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15568770/Estrogenic_and_anticarcinogenic_properties_of_kurarinone_a_lavandulyl_flavanone_from_the_roots_of_Sophora_flavescens_ L2 - https://doi.org/10.1021/np040069a DB - PRIME DP - Unbound Medicine ER -