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Time-related alteration of endolymph composition in an experimental model of endolymphatic hydrops.
Laryngoscope. 1992 Apr; 102(4):431-8.L

Abstract

The electrochemical changes of the inner ear fluids were studied in the guinea pig during the development of endolymphatic hydrops in an experimental model of Meniere's disease obtained by the blockage of the vestibular aqueduct. The endocochlear potential (first and third turns) was recorded, and the sodium, potassium, and chloride concentrations, and osmolality of the endolymph (first and third turns) and perilymph were determined at different intervals from 2 to 24 weeks after the induction of the hydrops. The development of hydrops was monitored by the compound action potential once a week during the observation period. In normal, nonoperated guinea pigs, longitudinal endolymphatic gradients of endocochlear potential, potassium and chloride concentrations, and osmolality, increasing from the apex to the base of the cochlea, were observed. After 2 weeks of hydrops, no alteration of this pattern was detected. After 6 and 9 weeks of hydrops, a progressive decrease of endocochlear potential, potassium and chloride concentrations, and osmolality was noticed at the first turn (6 and 9 weeks) and then at the third turn (9 weeks) which resulted in the disappearance of longitudinal gradients. At 24 weeks, the endocochlear potential was still diminished by 60%, whereas potassium and chloride concentrations and osmolality increased as compared to 9-week values but remained lower than in controls. The changes in composition of endolymph induced by the development of the hydrops could be related to the progressive alteration of the ionic permeability of the cochlear epithelium, which should be localized at the distended Reissner's membrane.

Authors+Show Affiliations

Département de Physiologie, Faculté Xavier Bichat, Université Paris 7, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1556894

Citation

Sziklai, I, et al. "Time-related Alteration of Endolymph Composition in an Experimental Model of Endolymphatic Hydrops." The Laryngoscope, vol. 102, no. 4, 1992, pp. 431-8.
Sziklai I, Ferrary E, Horner KC, et al. Time-related alteration of endolymph composition in an experimental model of endolymphatic hydrops. Laryngoscope. 1992;102(4):431-8.
Sziklai, I., Ferrary, E., Horner, K. C., Sterkers, O., & Amiel, C. (1992). Time-related alteration of endolymph composition in an experimental model of endolymphatic hydrops. The Laryngoscope, 102(4), 431-8.
Sziklai I, et al. Time-related Alteration of Endolymph Composition in an Experimental Model of Endolymphatic Hydrops. Laryngoscope. 1992;102(4):431-8. PubMed PMID: 1556894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time-related alteration of endolymph composition in an experimental model of endolymphatic hydrops. AU - Sziklai,I, AU - Ferrary,E, AU - Horner,K C, AU - Sterkers,O, AU - Amiel,C, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 431 EP - 8 JF - The Laryngoscope JO - Laryngoscope VL - 102 IS - 4 N2 - The electrochemical changes of the inner ear fluids were studied in the guinea pig during the development of endolymphatic hydrops in an experimental model of Meniere's disease obtained by the blockage of the vestibular aqueduct. The endocochlear potential (first and third turns) was recorded, and the sodium, potassium, and chloride concentrations, and osmolality of the endolymph (first and third turns) and perilymph were determined at different intervals from 2 to 24 weeks after the induction of the hydrops. The development of hydrops was monitored by the compound action potential once a week during the observation period. In normal, nonoperated guinea pigs, longitudinal endolymphatic gradients of endocochlear potential, potassium and chloride concentrations, and osmolality, increasing from the apex to the base of the cochlea, were observed. After 2 weeks of hydrops, no alteration of this pattern was detected. After 6 and 9 weeks of hydrops, a progressive decrease of endocochlear potential, potassium and chloride concentrations, and osmolality was noticed at the first turn (6 and 9 weeks) and then at the third turn (9 weeks) which resulted in the disappearance of longitudinal gradients. At 24 weeks, the endocochlear potential was still diminished by 60%, whereas potassium and chloride concentrations and osmolality increased as compared to 9-week values but remained lower than in controls. The changes in composition of endolymph induced by the development of the hydrops could be related to the progressive alteration of the ionic permeability of the cochlear epithelium, which should be localized at the distended Reissner's membrane. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/1556894/Time_related_alteration_of_endolymph_composition_in_an_experimental_model_of_endolymphatic_hydrops_ L2 - https://doi.org/10.1288/00005537-199204000-00011 DB - PRIME DP - Unbound Medicine ER -