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Recombination proteins in yeast.
Annu Rev Genet. 2004; 38:233-71.AR

Abstract

The process of homologous recombination promotes error-free repair of double-strand breaks and is essential for meiosis. Central to the process of homologous recombination are the RAD52 group genes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2), most of which were identified by their requirement for the repair of ionizing radiation-induced DNA damage in Saccharomyces cerevisiae. The Rad52 group proteins are highly conserved among eukaryotes. Recent studies showing defects in homologous recombination and double-strand break repair in several human cancer-prone syndromes have emphasized the importance of this repair pathway in maintaining genome integrity. Herein, we review recent genetic, biochemical, and structural analyses of the genes and proteins involved in recombination.

Authors+Show Affiliations

Columbia University Medical Center, New York, New York 10032, USA. bk2021@columbia.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15568977

Citation

Krogh, Berit Olsen, and Lorraine S. Symington. "Recombination Proteins in Yeast." Annual Review of Genetics, vol. 38, 2004, pp. 233-71.
Krogh BO, Symington LS. Recombination proteins in yeast. Annu Rev Genet. 2004;38:233-71.
Krogh, B. O., & Symington, L. S. (2004). Recombination proteins in yeast. Annual Review of Genetics, 38, 233-71.
Krogh BO, Symington LS. Recombination Proteins in Yeast. Annu Rev Genet. 2004;38:233-71. PubMed PMID: 15568977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recombination proteins in yeast. AU - Krogh,Berit Olsen, AU - Symington,Lorraine S, PY - 2004/12/1/pubmed PY - 2005/3/23/medline PY - 2004/12/1/entrez SP - 233 EP - 71 JF - Annual review of genetics JO - Annu Rev Genet VL - 38 N2 - The process of homologous recombination promotes error-free repair of double-strand breaks and is essential for meiosis. Central to the process of homologous recombination are the RAD52 group genes (RAD50, RAD51, RAD52, RAD54, RDH54/TID1, RAD55, RAD57, RAD59, MRE11, and XRS2), most of which were identified by their requirement for the repair of ionizing radiation-induced DNA damage in Saccharomyces cerevisiae. The Rad52 group proteins are highly conserved among eukaryotes. Recent studies showing defects in homologous recombination and double-strand break repair in several human cancer-prone syndromes have emphasized the importance of this repair pathway in maintaining genome integrity. Herein, we review recent genetic, biochemical, and structural analyses of the genes and proteins involved in recombination. SN - 0066-4197 UR - https://www.unboundmedicine.com/medline/citation/15568977/Recombination_proteins_in_yeast_ L2 - https://arjournals.annualreviews.org/doi/10.1146/annurev.genet.38.072902.091500?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -