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Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease.
Int J Dermatol. 2004 Dec; 43(12):900-3.IJ

Abstract

BACKGROUND

Behçet's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral-genital ulcers and uveitis. Some abnormalities in lipoprotein metabolism have been described in patients with BD.

METHODS

In this study, apolipoprotein E (apo E) polymorphism and lipoprotein cholesterol concentrations in 30 patients with BD were compared with those of 27 control subjects.

RESULTS

Both patients and controls were found to be normolipidemic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < 0.05); however, there was no difference in serum triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol concentrations. The distribution of apo E genotypes and alleles was the same in both groups. There were slight differences in allele frequency between the groups, but this was not statistically significant.

CONCLUSIONS

The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles.

Authors+Show Affiliations

Department of Dermatology, University of Mersin School of Medicine, Mersin, Turkey. utursen@mersin.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15569012

Citation

Tursen, Umit, et al. "Apolipoprotein E Polymorphism and Lipoprotein Compositions in Patients With Behçet's Disease." International Journal of Dermatology, vol. 43, no. 12, 2004, pp. 900-3.
Tursen U, Eskandari G, Kaya TI, et al. Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease. Int J Dermatol. 2004;43(12):900-3.
Tursen, U., Eskandari, G., Kaya, T. I., Tamer, L., Ikizoglu, G., & Atik, U. (2004). Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease. International Journal of Dermatology, 43(12), 900-3.
Tursen U, et al. Apolipoprotein E Polymorphism and Lipoprotein Compositions in Patients With Behçet's Disease. Int J Dermatol. 2004;43(12):900-3. PubMed PMID: 15569012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease. AU - Tursen,Umit, AU - Eskandari,Gulcin, AU - Kaya,Tamer Irfan, AU - Tamer,Lulufer, AU - Ikizoglu,Guliz, AU - Atik,Ugur, PY - 2004/12/1/pubmed PY - 2005/3/11/medline PY - 2004/12/1/entrez SP - 900 EP - 3 JF - International journal of dermatology JO - Int. J. Dermatol. VL - 43 IS - 12 N2 - BACKGROUND: Behçet's disease (BD) is a multisystemic disease of unknown etiology characterized by chronic relapsing oral-genital ulcers and uveitis. Some abnormalities in lipoprotein metabolism have been described in patients with BD. METHODS: In this study, apolipoprotein E (apo E) polymorphism and lipoprotein cholesterol concentrations in 30 patients with BD were compared with those of 27 control subjects. RESULTS: Both patients and controls were found to be normolipidemic. Patients with BD had significantly higher concentrations of high-density lipoprotein (HDL) cholesterol than those of controls (P < 0.05); however, there was no difference in serum triglyceride, low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) cholesterol concentrations. The distribution of apo E genotypes and alleles was the same in both groups. There were slight differences in allele frequency between the groups, but this was not statistically significant. CONCLUSIONS: The high HDL cholesterol levels observed in our patients were not related to abnormalities in apo E alleles. SN - 0011-9059 UR - https://www.unboundmedicine.com/medline/citation/15569012/Apolipoprotein_E_polymorphism_and_lipoprotein_compositions_in_patients_with_Behçet's_disease_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0011-9059&amp;date=2004&amp;volume=43&amp;issue=12&amp;spage=900 DB - PRIME DP - Unbound Medicine ER -