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Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes.
Acta Pharmacol Sin. 2004 Dec; 25(12):1597-605.AP

Abstract

AIM

To investigate the possibility whether THPB-18 (l-12-shloroscoulerine) possesses the D1 agonist-D2 antagonist action on meso-accumbens-mPFC DA system.

METHODS

Single unit spontaneous firing activity was recorded in the nucleus accumbens (NAc) neurons of naive and unilateral-6-hydroxydopamine (6-OHDA)-lesioned Sprague-Dawley rats. The effects of drugs applied intravenously or iontophoretically were determined by the change of firing rates.

RESULTS

Under normal conditions, the systemic administration of THPB-18 produced a decrease-increase biphasic firing pattern in the NAc neurons during cumulative doses. High dose of THPB-18 was capable of reversing the inhibition induced by both D2 agonist LY171555 and D1/D2 agonist APO on NAc firing activity. Spiperone pretreatment could not block the high dose of THPB-18-induced firing rate increase, which was reversed by the D1 selective antagonist SCH23390. The tested NAc neurons were effectively inhibited by iontophoretically applied THPB-18 in 90 % of 6-OHDA-lesioned rats, while THPB-18 caused variable effects on the firing of NAc neurons in the neurons of unlesioned rats. The inhibitory effect of THPB-18 was blocked by iontophoretic application of SCH23390, but not D2 antagonist spiperone.

CONCLUSION

Similar to L-stepholidine, THPB-18 also possesses the D1 agonistic-D2 antagonistic dual action on the VTA-NAc DA system.

Authors+Show Affiliations

State Key Laboratory of Drug Research,Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15569403

Citation

Fu, Yu, et al. "Biphasic Firing Response of Nucleus Accumbens Neurons Elicited By THPB-18 and Its Correlation With DA Receptor Subtypes." Acta Pharmacologica Sinica, vol. 25, no. 12, 2004, pp. 1597-605.
Fu Y, Zhu ZT, Zhu XZ, et al. Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes. Acta Pharmacol Sin. 2004;25(12):1597-605.
Fu, Y., Zhu, Z. T., Zhu, X. Z., & Jin, G. Z. (2004). Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes. Acta Pharmacologica Sinica, 25(12), 1597-605.
Fu Y, et al. Biphasic Firing Response of Nucleus Accumbens Neurons Elicited By THPB-18 and Its Correlation With DA Receptor Subtypes. Acta Pharmacol Sin. 2004;25(12):1597-605. PubMed PMID: 15569403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biphasic firing response of nucleus accumbens neurons elicited by THPB-18 and its correlation with DA receptor subtypes. AU - Fu,Yu, AU - Zhu,Zi-tao, AU - Zhu,Xin-zu, AU - Jin,Guo-zhang, PY - 2004/12/1/pubmed PY - 2005/6/25/medline PY - 2004/12/1/entrez SP - 1597 EP - 605 JF - Acta pharmacologica Sinica JO - Acta Pharmacol Sin VL - 25 IS - 12 N2 - AIM: To investigate the possibility whether THPB-18 (l-12-shloroscoulerine) possesses the D1 agonist-D2 antagonist action on meso-accumbens-mPFC DA system. METHODS: Single unit spontaneous firing activity was recorded in the nucleus accumbens (NAc) neurons of naive and unilateral-6-hydroxydopamine (6-OHDA)-lesioned Sprague-Dawley rats. The effects of drugs applied intravenously or iontophoretically were determined by the change of firing rates. RESULTS: Under normal conditions, the systemic administration of THPB-18 produced a decrease-increase biphasic firing pattern in the NAc neurons during cumulative doses. High dose of THPB-18 was capable of reversing the inhibition induced by both D2 agonist LY171555 and D1/D2 agonist APO on NAc firing activity. Spiperone pretreatment could not block the high dose of THPB-18-induced firing rate increase, which was reversed by the D1 selective antagonist SCH23390. The tested NAc neurons were effectively inhibited by iontophoretically applied THPB-18 in 90 % of 6-OHDA-lesioned rats, while THPB-18 caused variable effects on the firing of NAc neurons in the neurons of unlesioned rats. The inhibitory effect of THPB-18 was blocked by iontophoretic application of SCH23390, but not D2 antagonist spiperone. CONCLUSION: Similar to L-stepholidine, THPB-18 also possesses the D1 agonistic-D2 antagonistic dual action on the VTA-NAc DA system. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/15569403/Biphasic_firing_response_of_nucleus_accumbens_neurons_elicited_by_THPB_18_and_its_correlation_with_DA_receptor_subtypes_ L2 - http://www.chinaphar.com/1671-4083/25/1597.pdf DB - PRIME DP - Unbound Medicine ER -