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Association of estrogen receptor-alpha and vitamin D receptor genotypes with therapeutic response to calcium in postmenopausal Chinese women.
Acta Pharmacol Sin 2004; 25(12):1690-7AP

Abstract

AIM

To investigate the correlation between calcium treatment in postmenopausal women and estrogen receptor-alpha (ER-alpha) Xba I and Pvu II genotype and vitamin D receptor (VDR) Apa I genotype.

METHODS

One hundred fifteen postmenopausal Chinese women of Han population were enrolled and treated with calcichew-D3 (1000 mg calcium and 400 U vitamin D3) daily for 1 year. At entry and after 1 year treatment, the bone mineral density (BMD), serum and urinary bone turnover biochemical markers were evaluated. ER-alpha and VDR genotype were analyzed using PCR-restriction fragment length polymorphism.

RESULTS

After 1 year of calcium supplementation, a significant increase of BMD and a marked reduction in serum ALP and PTH levels, and a significant increase of serum 25-(OH) vitamin D level were observed (P<0.01 or P<0.05). At entry and after 1 year of treatment, no significant association was found between Xba I, Pvu II, and Apa I genotypes and BMD in L1-4, Neck, and Troch, and all bone turnover marker levels. However, the percentage of change (median, QR) in Neck BMD was significantly different in homozygous XX [-4.14 (from -6.54 to -1.34)] in comparison with Xx [1.72 (from -1.12 to 3.20)] (P<0.001) or xx [1.22 (from -1.74 to 3.06)] Xba I ER-alpha genotype (P=0.001).

CONCLUSION

Women with ER-alpha Xba I genotype XX may have a higher risk of relatively fast bone mass loss in femoral neck after menopause and that they may have a poor responsiveness to calcium supplementation. The changes in BMD are not associated with ER-alpha Pvu II genotype and VDR Apa I genotype after 1 year of calcium supplementation.

Authors+Show Affiliations

Center for Preventing and Treating Osteoporosis, Osteoporosis Research Unit, The Sixth People Hospital, Shanghai Jiaotong University, Shanghai 200233, China. ZZL2002@medmail.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15569417

Citation

Zhang, Zhen-lin, et al. "Association of Estrogen Receptor-alpha and Vitamin D Receptor Genotypes With Therapeutic Response to Calcium in Postmenopausal Chinese Women." Acta Pharmacologica Sinica, vol. 25, no. 12, 2004, pp. 1690-7.
Zhang ZL, Qin YJ, Huang QR, et al. Association of estrogen receptor-alpha and vitamin D receptor genotypes with therapeutic response to calcium in postmenopausal Chinese women. Acta Pharmacol Sin. 2004;25(12):1690-7.
Zhang, Z. L., Qin, Y. J., Huang, Q. R., He, J. W., Li, M., Zhou, Q., ... Li, Y. J. (2004). Association of estrogen receptor-alpha and vitamin D receptor genotypes with therapeutic response to calcium in postmenopausal Chinese women. Acta Pharmacologica Sinica, 25(12), pp. 1690-7.
Zhang ZL, et al. Association of Estrogen Receptor-alpha and Vitamin D Receptor Genotypes With Therapeutic Response to Calcium in Postmenopausal Chinese Women. Acta Pharmacol Sin. 2004;25(12):1690-7. PubMed PMID: 15569417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of estrogen receptor-alpha and vitamin D receptor genotypes with therapeutic response to calcium in postmenopausal Chinese women. AU - Zhang,Zhen-lin, AU - Qin,Yue-juan, AU - Huang,Qi-ren, AU - He,Jin-wei, AU - Li,Miao, AU - Zhou,Qi, AU - Hu,Yun-qin, AU - Li,Yu-juan, PY - 2004/12/1/pubmed PY - 2005/6/25/medline PY - 2004/12/1/entrez SP - 1690 EP - 7 JF - Acta pharmacologica Sinica JO - Acta Pharmacol. Sin. VL - 25 IS - 12 N2 - AIM: To investigate the correlation between calcium treatment in postmenopausal women and estrogen receptor-alpha (ER-alpha) Xba I and Pvu II genotype and vitamin D receptor (VDR) Apa I genotype. METHODS: One hundred fifteen postmenopausal Chinese women of Han population were enrolled and treated with calcichew-D3 (1000 mg calcium and 400 U vitamin D3) daily for 1 year. At entry and after 1 year treatment, the bone mineral density (BMD), serum and urinary bone turnover biochemical markers were evaluated. ER-alpha and VDR genotype were analyzed using PCR-restriction fragment length polymorphism. RESULTS: After 1 year of calcium supplementation, a significant increase of BMD and a marked reduction in serum ALP and PTH levels, and a significant increase of serum 25-(OH) vitamin D level were observed (P<0.01 or P<0.05). At entry and after 1 year of treatment, no significant association was found between Xba I, Pvu II, and Apa I genotypes and BMD in L1-4, Neck, and Troch, and all bone turnover marker levels. However, the percentage of change (median, QR) in Neck BMD was significantly different in homozygous XX [-4.14 (from -6.54 to -1.34)] in comparison with Xx [1.72 (from -1.12 to 3.20)] (P<0.001) or xx [1.22 (from -1.74 to 3.06)] Xba I ER-alpha genotype (P=0.001). CONCLUSION: Women with ER-alpha Xba I genotype XX may have a higher risk of relatively fast bone mass loss in femoral neck after menopause and that they may have a poor responsiveness to calcium supplementation. The changes in BMD are not associated with ER-alpha Pvu II genotype and VDR Apa I genotype after 1 year of calcium supplementation. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/15569417/Association_of_estrogen_receptor_alpha_and_vitamin_D_receptor_genotypes_with_therapeutic_response_to_calcium_in_postmenopausal_Chinese_women_ L2 - http://www.chinaphar.com/1671-4083/25/1690.pdf DB - PRIME DP - Unbound Medicine ER -