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Confirmation of synergy between urbanicity and familial liability in the causation of psychosis.
Am J Psychiatry. 2004 Dec; 161(12):2312-4.AJ

Abstract

OBJECTIVE

This study replicated a previous report that there may be substantial synergism between urbanicity (a proxy environmental risk factor) and familial clustering of psychotic disorder (a proxy genetic risk factor).

METHOD

The amount of synergism was estimated from the additive statistical interaction between urbanicity of place of birth and family history of schizophrenia or family history of any severe mental disorder in a population-based Danish cohort of 1,020,063 individuals.

RESULTS

There was significant interaction between urbanicity and family history; between 20% and 35% of individuals who had been exposed to both of these risk factors had schizophrenia possibly because of their synergistic effects.

CONCLUSIONS

The results suggest that a substantial proportion of the population morbidity force of schizophrenia may be the result of gene-environment interactions associated with urbanicity.

Authors+Show Affiliations

Maastricht University, P.O. Box 616, 6200 MD Maastricht, the Netherlands. j.vanos@sp.unimaas.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15569906

Citation

van Os, Jim, et al. "Confirmation of Synergy Between Urbanicity and Familial Liability in the Causation of Psychosis." The American Journal of Psychiatry, vol. 161, no. 12, 2004, pp. 2312-4.
van Os J, Pedersen CB, Mortensen PB. Confirmation of synergy between urbanicity and familial liability in the causation of psychosis. Am J Psychiatry. 2004;161(12):2312-4.
van Os, J., Pedersen, C. B., & Mortensen, P. B. (2004). Confirmation of synergy between urbanicity and familial liability in the causation of psychosis. The American Journal of Psychiatry, 161(12), 2312-4.
van Os J, Pedersen CB, Mortensen PB. Confirmation of Synergy Between Urbanicity and Familial Liability in the Causation of Psychosis. Am J Psychiatry. 2004;161(12):2312-4. PubMed PMID: 15569906.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Confirmation of synergy between urbanicity and familial liability in the causation of psychosis. AU - van Os,Jim, AU - Pedersen,Carsten B, AU - Mortensen,Preben B, PY - 2004/12/1/pubmed PY - 2005/1/29/medline PY - 2004/12/1/entrez SP - 2312 EP - 4 JF - The American journal of psychiatry JO - Am J Psychiatry VL - 161 IS - 12 N2 - OBJECTIVE: This study replicated a previous report that there may be substantial synergism between urbanicity (a proxy environmental risk factor) and familial clustering of psychotic disorder (a proxy genetic risk factor). METHOD: The amount of synergism was estimated from the additive statistical interaction between urbanicity of place of birth and family history of schizophrenia or family history of any severe mental disorder in a population-based Danish cohort of 1,020,063 individuals. RESULTS: There was significant interaction between urbanicity and family history; between 20% and 35% of individuals who had been exposed to both of these risk factors had schizophrenia possibly because of their synergistic effects. CONCLUSIONS: The results suggest that a substantial proportion of the population morbidity force of schizophrenia may be the result of gene-environment interactions associated with urbanicity. SN - 0002-953X UR - https://www.unboundmedicine.com/medline/citation/15569906/Confirmation_of_synergy_between_urbanicity_and_familial_liability_in_the_causation_of_psychosis_ L2 - https://ajp.psychiatryonline.org/doi/full/10.1176/appi.ajp.161.12.2312?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -