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Potential synergy of phytochemicals in cancer prevention: mechanism of action.
J Nutr 2004; 134(12 Suppl):3479S-3485SJN

Abstract

Epidemiological studies have consistently shown that regular consumption of fruits and vegetables is strongly associated with reduced risk of developing chronic diseases, such as cancer and cardiovascular disease. It is now widely believed that the actions of the antioxidant nutrients alone do not explain the observed health benefits of diets rich in fruits and vegetables, because taken alone, the individual antioxidants studied in clinical trials do not appear to have consistent preventive effects. Work performed by our group and others has shown that fruits and vegetable phytochemical extracts exhibit strong antioxidant and antiproliferative activities and that the major part of total antioxidant activity is from the combination of phytochemicals. We proposed that the additive and synergistic effects of phytochemicals in fruits and vegetables are responsible for these potent antioxidant and anticancer activities and that the benefit of a diet rich in fruits and vegetables is attributed to the complex mixture of phytochemicals present in whole foods. This explains why no single antioxidant can replace the combination of natural phytochemicals in fruits and vegetables to achieve the health benefits. The evidence suggests that antioxidants or bioactive compounds are best acquired through whole-food consumption, not from expensive dietary supplements. We believe that a recommendation that consumers eat 5 to 10 servings of a wide variety of fruits and vegetables daily is an appropriate strategy for significantly reducing the risk of chronic diseases and to meet their nutrient requirements for optimum health.

Authors+Show Affiliations

Department of Food Science, Cornell University, Ithaca, NY 14853, USA. RL23@cornell.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15570057

Citation

Liu, Rui Hai. "Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action." The Journal of Nutrition, vol. 134, no. 12 Suppl, 2004, 3479S-3485S.
Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr. 2004;134(12 Suppl):3479S-3485S.
Liu, R. H. (2004). Potential synergy of phytochemicals in cancer prevention: mechanism of action. The Journal of Nutrition, 134(12 Suppl), 3479S-3485S. doi:10.1093/jn/134.12.3479S.
Liu RH. Potential Synergy of Phytochemicals in Cancer Prevention: Mechanism of Action. J Nutr. 2004;134(12 Suppl):3479S-3485S. PubMed PMID: 15570057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential synergy of phytochemicals in cancer prevention: mechanism of action. A1 - Liu,Rui Hai, PY - 2004/12/1/pubmed PY - 2005/1/14/medline PY - 2004/12/1/entrez SP - 3479S EP - 3485S JF - The Journal of nutrition JO - J. Nutr. VL - 134 IS - 12 Suppl N2 - Epidemiological studies have consistently shown that regular consumption of fruits and vegetables is strongly associated with reduced risk of developing chronic diseases, such as cancer and cardiovascular disease. It is now widely believed that the actions of the antioxidant nutrients alone do not explain the observed health benefits of diets rich in fruits and vegetables, because taken alone, the individual antioxidants studied in clinical trials do not appear to have consistent preventive effects. Work performed by our group and others has shown that fruits and vegetable phytochemical extracts exhibit strong antioxidant and antiproliferative activities and that the major part of total antioxidant activity is from the combination of phytochemicals. We proposed that the additive and synergistic effects of phytochemicals in fruits and vegetables are responsible for these potent antioxidant and anticancer activities and that the benefit of a diet rich in fruits and vegetables is attributed to the complex mixture of phytochemicals present in whole foods. This explains why no single antioxidant can replace the combination of natural phytochemicals in fruits and vegetables to achieve the health benefits. The evidence suggests that antioxidants or bioactive compounds are best acquired through whole-food consumption, not from expensive dietary supplements. We believe that a recommendation that consumers eat 5 to 10 servings of a wide variety of fruits and vegetables daily is an appropriate strategy for significantly reducing the risk of chronic diseases and to meet their nutrient requirements for optimum health. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/15570057/Potential_synergy_of_phytochemicals_in_cancer_prevention:_mechanism_of_action_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/134.12.3479S DB - PRIME DP - Unbound Medicine ER -