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Tomato phytochemicals and prostate cancer risk.
J Nutr. 2004 12; 134(12 Suppl):3486S-3492S.JN

Abstract

Mounting evidence over the past decade suggests that the consumption of fresh and processed tomato products is associated with reduced risk of prostate cancer. The emerging hypothesis is that lycopene, the primary red carotenoid in tomatoes, may be the principle phytochemical responsible for this reduction in risk. A number of potential mechanisms by which lycopene may act have emerged, including serving as an important in vivo antioxidant, enhancing cell-to-cell communication via increasing gap junctions between cells, and modulating cell-cycle progression. Although the effect of lycopene is biologically relevant, the tomato is also an excellent source of nutrients, including folate, vitamin C, and various other carotenoids and phytochemicals, such as polyphenols, which also may be associated with lower cancer risk. Tomatoes also contain significant quantities of potassium, as well as some vitamin A and vitamin E. Our laboratory has been interested in identifying specific components or combination of components in tomatoes that are responsible for reducing prostate cancer risk. We carried out cell culture trials to evaluate the effects of tomato carotenoids and tomato polyphenols on growth of prostate cancer cells. We also evaluated the ability of freeze-dried whole-tomato powder or lycopene alone to reduce growth of prostate tumors in rats. This paper reviews the epidemiological evidence, evaluating the relationship between prostate cancer risk and tomato consumption, and presents experimental data from this and other laboratories that support the hypothesis that whole tomato and its phytochemical components reduce the risk of prostate cancer.

Authors+Show Affiliations

Division of Nutritional Sciences, University of Illinois, Urbana, IL 61801, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

15570058

Citation

Campbell, Jessica K., et al. "Tomato Phytochemicals and Prostate Cancer Risk." The Journal of Nutrition, vol. 134, no. 12 Suppl, 2004, 3486S-3492S.
Campbell JK, Canene-Adams K, Lindshield BL, et al. Tomato phytochemicals and prostate cancer risk. J Nutr. 2004;134(12 Suppl):3486S-3492S.
Campbell, J. K., Canene-Adams, K., Lindshield, B. L., Boileau, T. W., Clinton, S. K., & Erdman, J. W. (2004). Tomato phytochemicals and prostate cancer risk. The Journal of Nutrition, 134(12 Suppl), 3486S-3492S. https://doi.org/10.1093/jn/134.12.3486S
Campbell JK, et al. Tomato Phytochemicals and Prostate Cancer Risk. J Nutr. 2004;134(12 Suppl):3486S-3492S. PubMed PMID: 15570058.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tomato phytochemicals and prostate cancer risk. AU - Campbell,Jessica K, AU - Canene-Adams,Kirstie, AU - Lindshield,Brian L, AU - Boileau,Thomas W-M, AU - Clinton,Steven K, AU - Erdman,John W,Jr PY - 2004/12/1/pubmed PY - 2005/1/14/medline PY - 2004/12/1/entrez SP - 3486S EP - 3492S JF - The Journal of nutrition JO - J. Nutr. VL - 134 IS - 12 Suppl N2 - Mounting evidence over the past decade suggests that the consumption of fresh and processed tomato products is associated with reduced risk of prostate cancer. The emerging hypothesis is that lycopene, the primary red carotenoid in tomatoes, may be the principle phytochemical responsible for this reduction in risk. A number of potential mechanisms by which lycopene may act have emerged, including serving as an important in vivo antioxidant, enhancing cell-to-cell communication via increasing gap junctions between cells, and modulating cell-cycle progression. Although the effect of lycopene is biologically relevant, the tomato is also an excellent source of nutrients, including folate, vitamin C, and various other carotenoids and phytochemicals, such as polyphenols, which also may be associated with lower cancer risk. Tomatoes also contain significant quantities of potassium, as well as some vitamin A and vitamin E. Our laboratory has been interested in identifying specific components or combination of components in tomatoes that are responsible for reducing prostate cancer risk. We carried out cell culture trials to evaluate the effects of tomato carotenoids and tomato polyphenols on growth of prostate cancer cells. We also evaluated the ability of freeze-dried whole-tomato powder or lycopene alone to reduce growth of prostate tumors in rats. This paper reviews the epidemiological evidence, evaluating the relationship between prostate cancer risk and tomato consumption, and presents experimental data from this and other laboratories that support the hypothesis that whole tomato and its phytochemical components reduce the risk of prostate cancer. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/15570058/Tomato_phytochemicals_and_prostate_cancer_risk_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/134.12.3486S DB - PRIME DP - Unbound Medicine ER -