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Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study.
J Clin Oncol. 2004 Dec 01; 22(23):4829-36.JC

Abstract

PURPOSE

Quality of life (QOL) has become an important outcome measure for patients with cancer, but long-term results from population-based studies are rare. The objective of our study was to identify specific limitations of QOL in survivors of colorectal cancer in comparison with men and women from the general population 1 year after diagnosis when acute treatment effects are expected to have declined.

PATIENTS AND METHODS

QOL was assessed 1 year after diagnosis in a population-based cohort of 439 patients with colorectal cancer from Saarland (Germany) using the EORTC-QLC30 questionnaire. Specific functional and symptom QOL scores were compared with published reference data from the general population.

RESULTS

Of 439 patients, 378 of them survived the first year after tumor diagnosis (86.1%). Of these, 309 returned the questionnaire (response rate, 81.7%). Compared with the general population, colorectal cancer patients scored their physical, role, cognitive, and global health functioning only slightly worse. More severe limitations were observed for the emotional and social functioning scales and for the symptom subscales of fatigue, dyspnea, insomnia, constipation, diarrhea, and financial difficulties. The differences regarding functional and symptom scores were predominantly found in younger age groups whereas older cancer patients and controls rated their health and QOL similarly.

CONCLUSION

Deficits in emotional and social functioning and specific limitations like fatigue, dyspnea, insomnia, constipation, diarrhea, and financial difficulties are main factors hampering the QOL among colorectal cancer patients and seem to affect predominantly younger patients.

Authors+Show Affiliations

Department of Epidemiology, German Centre for Research on Aging, Heidelberg, Germany. arndt@dzfa.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15570086

Citation

Arndt, Volker, et al. "Quality of Life in Patients With Colorectal Cancer 1 Year After Diagnosis Compared With the General Population: a Population-based Study." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, vol. 22, no. 23, 2004, pp. 4829-36.
Arndt V, Merx H, Stegmaier C, et al. Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study. J Clin Oncol. 2004;22(23):4829-36.
Arndt, V., Merx, H., Stegmaier, C., Ziegler, H., & Brenner, H. (2004). Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology, 22(23), 4829-36.
Arndt V, et al. Quality of Life in Patients With Colorectal Cancer 1 Year After Diagnosis Compared With the General Population: a Population-based Study. J Clin Oncol. 2004 Dec 1;22(23):4829-36. PubMed PMID: 15570086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quality of life in patients with colorectal cancer 1 year after diagnosis compared with the general population: a population-based study. AU - Arndt,Volker, AU - Merx,Henrike, AU - Stegmaier,Christa, AU - Ziegler,Hartwig, AU - Brenner,Hermann, PY - 2004/12/1/pubmed PY - 2005/1/5/medline PY - 2004/12/1/entrez SP - 4829 EP - 36 JF - Journal of clinical oncology : official journal of the American Society of Clinical Oncology JO - J. Clin. Oncol. VL - 22 IS - 23 N2 - PURPOSE: Quality of life (QOL) has become an important outcome measure for patients with cancer, but long-term results from population-based studies are rare. The objective of our study was to identify specific limitations of QOL in survivors of colorectal cancer in comparison with men and women from the general population 1 year after diagnosis when acute treatment effects are expected to have declined. PATIENTS AND METHODS: QOL was assessed 1 year after diagnosis in a population-based cohort of 439 patients with colorectal cancer from Saarland (Germany) using the EORTC-QLC30 questionnaire. Specific functional and symptom QOL scores were compared with published reference data from the general population. RESULTS: Of 439 patients, 378 of them survived the first year after tumor diagnosis (86.1%). Of these, 309 returned the questionnaire (response rate, 81.7%). Compared with the general population, colorectal cancer patients scored their physical, role, cognitive, and global health functioning only slightly worse. More severe limitations were observed for the emotional and social functioning scales and for the symptom subscales of fatigue, dyspnea, insomnia, constipation, diarrhea, and financial difficulties. The differences regarding functional and symptom scores were predominantly found in younger age groups whereas older cancer patients and controls rated their health and QOL similarly. CONCLUSION: Deficits in emotional and social functioning and specific limitations like fatigue, dyspnea, insomnia, constipation, diarrhea, and financial difficulties are main factors hampering the QOL among colorectal cancer patients and seem to affect predominantly younger patients. SN - 0732-183X UR - https://www.unboundmedicine.com/medline/citation/15570086/Quality_of_life_in_patients_with_colorectal_cancer_1_year_after_diagnosis_compared_with_the_general_population:_a_population_based_study_ L2 - http://ascopubs.org/doi/full/10.1200/JCO.2004.02.018?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -