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Subjective memory deterioration and future dementia in people aged 65 and older.
J Am Geriatr Soc 2004; 52(12):2045-51JA

Abstract

OBJECTIVES

To study whether subjective memory deterioration is associated with future dementia in older people.

DESIGN

A population-based prospective cohort study begun in 1994 with biennial follow-up interviews.

SETTING

Community-based members of Group Health Cooperative, a large health maintenance organization in the Seattle area.

PARTICIPANTS

A sample of 1,883 subjects, dementia free, aged 65 and older, who scored 91 or higher on the 100-point Cognitive Ability Screening Instrument (CASI) at study entry.

MEASUREMENTS

Subjective memory was assessed by asking whether memory had changed on 5-point Likert scales (e.g., 1=definitely improved, 3=no change, 5=definitely deteriorated) with regard to five items: remembering names, faces, friends, and appointments and judging the time. The items were summed for a possible total score ranging from 5 to 25. Subjective memory deterioration was defined as present if the total score was 20 or above. Cognitive performance was measured using the CASI. Incident dementia cases were identified using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria.

RESULTS

Of 1,883 subjects, 126 developed dementia during 5 years of follow-up. Subjective memory deterioration was associated with cognitive decline and incident dementia. Age modified the association between subjective memory deterioration and future dementia. For persons reporting subjective memory deterioration at the ages of 70, 75, and 80, the hazard ratios of developing dementia were 6.0 (95% confidence interval (CI)=2.1-18), 3.2 (95% CI=1.6-6.2) and 1.6 (95% CI=0.86-3.1), respectively.

CONCLUSION

Subjective memory deterioration was found to precede the development of dementia in older people with normal cognitive screening results. These findings suggest that a high level of subjective memory deterioration in persons with normal objective cognitive function may identify a subset of individuals at greater risk for developing dementia.

Authors+Show Affiliations

Department of Medicine, University of Washington, Seattle, Washington 98195, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15571540

Citation

Wang, Li, et al. "Subjective Memory Deterioration and Future Dementia in People Aged 65 and Older." Journal of the American Geriatrics Society, vol. 52, no. 12, 2004, pp. 2045-51.
Wang L, van Belle G, Crane PK, et al. Subjective memory deterioration and future dementia in people aged 65 and older. J Am Geriatr Soc. 2004;52(12):2045-51.
Wang, L., van Belle, G., Crane, P. K., Kukull, W. A., Bowen, J. D., McCormick, W. C., & Larson, E. B. (2004). Subjective memory deterioration and future dementia in people aged 65 and older. Journal of the American Geriatrics Society, 52(12), pp. 2045-51.
Wang L, et al. Subjective Memory Deterioration and Future Dementia in People Aged 65 and Older. J Am Geriatr Soc. 2004;52(12):2045-51. PubMed PMID: 15571540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subjective memory deterioration and future dementia in people aged 65 and older. AU - Wang,Li, AU - van Belle,Gerald, AU - Crane,Paul K, AU - Kukull,Walter A, AU - Bowen,James D, AU - McCormick,Wayne C, AU - Larson,Eric B, PY - 2004/12/2/pubmed PY - 2005/1/19/medline PY - 2004/12/2/entrez SP - 2045 EP - 51 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 52 IS - 12 N2 - OBJECTIVES: To study whether subjective memory deterioration is associated with future dementia in older people. DESIGN: A population-based prospective cohort study begun in 1994 with biennial follow-up interviews. SETTING: Community-based members of Group Health Cooperative, a large health maintenance organization in the Seattle area. PARTICIPANTS: A sample of 1,883 subjects, dementia free, aged 65 and older, who scored 91 or higher on the 100-point Cognitive Ability Screening Instrument (CASI) at study entry. MEASUREMENTS: Subjective memory was assessed by asking whether memory had changed on 5-point Likert scales (e.g., 1=definitely improved, 3=no change, 5=definitely deteriorated) with regard to five items: remembering names, faces, friends, and appointments and judging the time. The items were summed for a possible total score ranging from 5 to 25. Subjective memory deterioration was defined as present if the total score was 20 or above. Cognitive performance was measured using the CASI. Incident dementia cases were identified using Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria. RESULTS: Of 1,883 subjects, 126 developed dementia during 5 years of follow-up. Subjective memory deterioration was associated with cognitive decline and incident dementia. Age modified the association between subjective memory deterioration and future dementia. For persons reporting subjective memory deterioration at the ages of 70, 75, and 80, the hazard ratios of developing dementia were 6.0 (95% confidence interval (CI)=2.1-18), 3.2 (95% CI=1.6-6.2) and 1.6 (95% CI=0.86-3.1), respectively. CONCLUSION: Subjective memory deterioration was found to precede the development of dementia in older people with normal cognitive screening results. These findings suggest that a high level of subjective memory deterioration in persons with normal objective cognitive function may identify a subset of individuals at greater risk for developing dementia. SN - 0002-8614 UR - https://www.unboundmedicine.com/medline/citation/15571540/Subjective_memory_deterioration_and_future_dementia_in_people_aged_65_and_older_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0002-8614&date=2004&volume=52&issue=12&spage=2045 DB - PRIME DP - Unbound Medicine ER -