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Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular disease.
J Autoimmun. 2004 Dec; 23(4):353-60.JA

Abstract

Anti-apolipoprotein A-1 (Apo A-1) autoantibodies were described in autoimmune disorders such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) and might be involved in the genesis of arterial and venous thrombotic events. To investigate the presence of these autoantibodies in patients with acute coronary syndrome (ACS) without other features of autoimmunity, we set up an enzyme-linked immunosorbent assay (ELISA) for anti-Apo A-1 antibodies. We used it to investigate their prevalence in ACS as compared to SLE and APS and correlated them to plasma Apo A-1 and serum amyloid A protein (SAA) concentrations. The prevalence of anti-Apo A-1 autoantibodies in the healthy control group was 1% (1/92), but was significantly higher in other groups: 21% (11/53) in ACS group (P=0.001), 13% (12/92) in SLE and/or APS group (P=0.005). Multiple linear regression revealed a significant correlation between plasma Apo A-1 (r=-0.72, P=0.013), plasma SAA concentration (r=0.76, P=0.0066) and anti-Apo A-1 IgG titre in ACS patients. The presence of anti-Apo A-1 autoantibodies in patients with ACS highlights an additional link between autoimmunity, inflammation and atherosclerosis.

Authors+Show Affiliations

Division of Immunology and Allergy and Department of Internal Medicine, Geneva University Hospital, 24 Micheli-Du-Crest, 1211 Geneva 14, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15571929

Citation

Vuilleumier, Nicolas, et al. "Presence of Autoantibodies to Apolipoprotein A-1 in Patients With Acute Coronary Syndrome Further Links Autoimmunity to Cardiovascular Disease." Journal of Autoimmunity, vol. 23, no. 4, 2004, pp. 353-60.
Vuilleumier N, Reber G, James R, et al. Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular disease. J Autoimmun. 2004;23(4):353-60.
Vuilleumier, N., Reber, G., James, R., Burger, D., de Moerloose, P., Dayer, J. M., & Roux-Lombard, P. (2004). Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular disease. Journal of Autoimmunity, 23(4), 353-60.
Vuilleumier N, et al. Presence of Autoantibodies to Apolipoprotein A-1 in Patients With Acute Coronary Syndrome Further Links Autoimmunity to Cardiovascular Disease. J Autoimmun. 2004;23(4):353-60. PubMed PMID: 15571929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Presence of autoantibodies to apolipoprotein A-1 in patients with acute coronary syndrome further links autoimmunity to cardiovascular disease. AU - Vuilleumier,Nicolas, AU - Reber,Guido, AU - James,Richard, AU - Burger,Danielle, AU - de Moerloose,Philippe, AU - Dayer,Jean-Michel, AU - Roux-Lombard,Pascale, PY - 2004/06/14/received PY - 2004/07/27/revised PY - 2004/08/03/accepted PY - 2004/12/2/pubmed PY - 2005/6/15/medline PY - 2004/12/2/entrez SP - 353 EP - 60 JF - Journal of autoimmunity JO - J Autoimmun VL - 23 IS - 4 N2 - Anti-apolipoprotein A-1 (Apo A-1) autoantibodies were described in autoimmune disorders such as systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) and might be involved in the genesis of arterial and venous thrombotic events. To investigate the presence of these autoantibodies in patients with acute coronary syndrome (ACS) without other features of autoimmunity, we set up an enzyme-linked immunosorbent assay (ELISA) for anti-Apo A-1 antibodies. We used it to investigate their prevalence in ACS as compared to SLE and APS and correlated them to plasma Apo A-1 and serum amyloid A protein (SAA) concentrations. The prevalence of anti-Apo A-1 autoantibodies in the healthy control group was 1% (1/92), but was significantly higher in other groups: 21% (11/53) in ACS group (P=0.001), 13% (12/92) in SLE and/or APS group (P=0.005). Multiple linear regression revealed a significant correlation between plasma Apo A-1 (r=-0.72, P=0.013), plasma SAA concentration (r=0.76, P=0.0066) and anti-Apo A-1 IgG titre in ACS patients. The presence of anti-Apo A-1 autoantibodies in patients with ACS highlights an additional link between autoimmunity, inflammation and atherosclerosis. SN - 0896-8411 UR - https://www.unboundmedicine.com/medline/citation/15571929/Presence_of_autoantibodies_to_apolipoprotein_A_1_in_patients_with_acute_coronary_syndrome_further_links_autoimmunity_to_cardiovascular_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0896-8411(04)00091-5 DB - PRIME DP - Unbound Medicine ER -