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Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions.
Am J Physiol Endocrinol Metab. 2005 Jun; 288(6):E1153-9.AJ

Abstract

We aimed to determine whether there were differences in the extent and time course of skeletal muscle myofibrillar protein synthesis (MPS) and muscle collagen protein synthesis (CPS) in human skeletal muscle in an 8.5-h period after bouts of maximal muscle shortening (SC; average peak torque = 225 +/- 7 N.m, means +/- SE) or lengthening contractions (LC; average peak torque = 299 +/- 18 N.m) with equivalent work performed in each mode. Eight healthy young men (21.9 +/- 0.6 yr, body mass index 24.9 +/- 1.3 kg/m2) performed 6 sets of 10 maximal unilateral LC of the knee extensors on an isokinetic dynamometer. With the contralateral leg, they then performed 6 sets of maximal unilateral SC with work matched to the total work performed during LC (10.9 +/- 0.7 vs. 10.9 +/- 0.8 kJ, P = 0.83). After exercise, the participants consumed small intermittent meals to provide 0.1 g.kg(-1).h(-1) of protein and carbohydrate. Prior exercise elevated MPS above rest in both conditions, but there was a more rapid rise after LC (P < 0.01). The increases (P < 0.001) in CPS above rest were identical for both SC and LC and likely represent a remodeling of the myofibrillar basement membrane. Therefore, a more rapid rise in MPS after maximal LC could translate into greater protein accretion and muscle hypertrophy during chronic resistance training utilizing maximal LC.

Authors+Show Affiliations

Dept. of Kinesiology, Exercise Metabolism Research Group, McMaster Univ., 1280 Main St. W., Hamilton, ON, Canada L8S 4K1.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15572656

Citation

Moore, Daniel R., et al. "Myofibrillar and Collagen Protein Synthesis in Human Skeletal Muscle in Young Men After Maximal Shortening and Lengthening Contractions." American Journal of Physiology. Endocrinology and Metabolism, vol. 288, no. 6, 2005, pp. E1153-9.
Moore DR, Phillips SM, Babraj JA, et al. Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. Am J Physiol Endocrinol Metab. 2005;288(6):E1153-9.
Moore, D. R., Phillips, S. M., Babraj, J. A., Smith, K., & Rennie, M. J. (2005). Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. American Journal of Physiology. Endocrinology and Metabolism, 288(6), E1153-9.
Moore DR, et al. Myofibrillar and Collagen Protein Synthesis in Human Skeletal Muscle in Young Men After Maximal Shortening and Lengthening Contractions. Am J Physiol Endocrinol Metab. 2005;288(6):E1153-9. PubMed PMID: 15572656.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. AU - Moore,Daniel R, AU - Phillips,Stuart M, AU - Babraj,John A, AU - Smith,Kenneth, AU - Rennie,Michael J, Y1 - 2004/11/30/ PY - 2004/12/2/pubmed PY - 2005/6/17/medline PY - 2004/12/2/entrez SP - E1153 EP - 9 JF - American journal of physiology. Endocrinology and metabolism JO - Am J Physiol Endocrinol Metab VL - 288 IS - 6 N2 - We aimed to determine whether there were differences in the extent and time course of skeletal muscle myofibrillar protein synthesis (MPS) and muscle collagen protein synthesis (CPS) in human skeletal muscle in an 8.5-h period after bouts of maximal muscle shortening (SC; average peak torque = 225 +/- 7 N.m, means +/- SE) or lengthening contractions (LC; average peak torque = 299 +/- 18 N.m) with equivalent work performed in each mode. Eight healthy young men (21.9 +/- 0.6 yr, body mass index 24.9 +/- 1.3 kg/m2) performed 6 sets of 10 maximal unilateral LC of the knee extensors on an isokinetic dynamometer. With the contralateral leg, they then performed 6 sets of maximal unilateral SC with work matched to the total work performed during LC (10.9 +/- 0.7 vs. 10.9 +/- 0.8 kJ, P = 0.83). After exercise, the participants consumed small intermittent meals to provide 0.1 g.kg(-1).h(-1) of protein and carbohydrate. Prior exercise elevated MPS above rest in both conditions, but there was a more rapid rise after LC (P < 0.01). The increases (P < 0.001) in CPS above rest were identical for both SC and LC and likely represent a remodeling of the myofibrillar basement membrane. Therefore, a more rapid rise in MPS after maximal LC could translate into greater protein accretion and muscle hypertrophy during chronic resistance training utilizing maximal LC. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/15572656/Myofibrillar_and_collagen_protein_synthesis_in_human_skeletal_muscle_in_young_men_after_maximal_shortening_and_lengthening_contractions_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.00387.2004?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -