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Executive function impairment in community elderly subjects with questionable dementia.
Dement Geriatr Cogn Disord. 2005; 19(2-3):86-90.DG

Abstract

BACKGROUND

The neurocognitive profile of community-dwelling Chinese subjects with 'questionable' dementia was studied.

METHODS

One hundred and fifty-four ambulatory Chinese subjects were recruited from local social centers for the elderly. Each subject was examined using the Clinical Dementia Rating (CDR), the Cantonese version of the Mini-Mental State Examination (CMMSE), the Chinese version of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), the Category Verbal Fluency Test (CVFT), digit and visual span tests, and the Cambridge Neurological Inventory. The neurocognitive profile of nondemented subjects (CDR 0) was compared with that of subjects with 'questionable' dementia (CDR 0.5).

RESULTS

Subjects with 'questionable' dementia were older, and had lower educational levels and global cognitive assessment scores than the controls (CMMSE and ADAS-Cog; t tests, p < 0.001). In addition, they also had significantly lower scores in delayed recall, reverse span, verbal fluency tests and worse performance in complex motor tasks related to executive function (Mann-Whitney tests, p < 0.001). Logistic regression analysis revealed that ADAS-Cog, CVFT, and reverse visual span were significant predictors for the CDR of 'questionable' dementia.

CONCLUSION

Aside from memory impairment, executive function deficits were also present in subjects with 'questionable' dementia. To identify groups cognitively at risk for dementia, concomitant assessments of memory and executive function are suggested.

Authors+Show Affiliations

Department of Psychiatry, Chinese University of Hong Kong, Shatin, Hong Kong SAR. cwlam@cuhk.edu.hkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15572877

Citation

Lam, Linda C W., et al. "Executive Function Impairment in Community Elderly Subjects With Questionable Dementia." Dementia and Geriatric Cognitive Disorders, vol. 19, no. 2-3, 2005, pp. 86-90.
Lam LC, Lui VW, Chiu HF, et al. Executive function impairment in community elderly subjects with questionable dementia. Dement Geriatr Cogn Disord. 2005;19(2-3):86-90.
Lam, L. C., Lui, V. W., Chiu, H. F., Chan, S. S., & Tam, C. W. (2005). Executive function impairment in community elderly subjects with questionable dementia. Dementia and Geriatric Cognitive Disorders, 19(2-3), 86-90.
Lam LC, et al. Executive Function Impairment in Community Elderly Subjects With Questionable Dementia. Dement Geriatr Cogn Disord. 2005;19(2-3):86-90. PubMed PMID: 15572877.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Executive function impairment in community elderly subjects with questionable dementia. AU - Lam,Linda C W, AU - Lui,Victor W C, AU - Chiu,Helen F K, AU - Chan,Sandra S M, AU - Tam,Cindy W C, Y1 - 2004/11/29/ PY - 2004/06/15/accepted PY - 2004/12/2/pubmed PY - 2005/6/25/medline PY - 2004/12/2/entrez SP - 86 EP - 90 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 19 IS - 2-3 N2 - BACKGROUND: The neurocognitive profile of community-dwelling Chinese subjects with 'questionable' dementia was studied. METHODS: One hundred and fifty-four ambulatory Chinese subjects were recruited from local social centers for the elderly. Each subject was examined using the Clinical Dementia Rating (CDR), the Cantonese version of the Mini-Mental State Examination (CMMSE), the Chinese version of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), the Category Verbal Fluency Test (CVFT), digit and visual span tests, and the Cambridge Neurological Inventory. The neurocognitive profile of nondemented subjects (CDR 0) was compared with that of subjects with 'questionable' dementia (CDR 0.5). RESULTS: Subjects with 'questionable' dementia were older, and had lower educational levels and global cognitive assessment scores than the controls (CMMSE and ADAS-Cog; t tests, p < 0.001). In addition, they also had significantly lower scores in delayed recall, reverse span, verbal fluency tests and worse performance in complex motor tasks related to executive function (Mann-Whitney tests, p < 0.001). Logistic regression analysis revealed that ADAS-Cog, CVFT, and reverse visual span were significant predictors for the CDR of 'questionable' dementia. CONCLUSION: Aside from memory impairment, executive function deficits were also present in subjects with 'questionable' dementia. To identify groups cognitively at risk for dementia, concomitant assessments of memory and executive function are suggested. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/15572877/Executive_function_impairment_in_community_elderly_subjects_with_questionable_dementia_ L2 - https://www.karger.com?DOI=10.1159/000082354 DB - PRIME DP - Unbound Medicine ER -