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Preemptive gabapentin decreases postoperative pain after lumbar discoidectomy.
Can J Anaesth. 2004 Dec; 51(10):986-9.CJ

Abstract

PURPOSE

We investigated whether the preemptive use of gabapentin, a structural analogue of gamma amino butyric acid could reduce postoperative pain and fentanyl consumption in patients after single-level lumbar discoidectomy.

METHODS

Fifty-six ASA I and II patients were randomly allocated into two equal groups to receive either gabapentin 300 mg or placebo two hours before surgery. After surgery, the pain was assessed on a visual analogue scale (VAS) at intervals of 0-6, 6-12, 12-18, and 18-24 hr at rest. Total fentanyl consumption in the first 24 hr after surgery was also recorded. Fentanyl 2 mug.kg(-1) intravenously was used to treat postoperative pain on patients' demand.

RESULTS

Patients in the gabapentin group had significantly lower VAS scores at all time intervals of 0-6, 6-12, 12-18, and 18-24 hr than those in the placebo group (3.5 +/- 2.3, 3.2 +/- 2.1, 1.8 +/- 1.7, 1.2 +/- 1.3 vs 6.1 +/- 1.7, 4.4 +/- 1.2, 3.3 +/- 1.1, 2.1 +/- 1.2; P < 0.05). The total fentanyl consumed after surgery in the first 24 hr in the gabapentin group (233.5 +/- 141.9, mean + SD) was significantly less than in the placebo group (359.6 +/- 104.1; P < 0.05).

CONCLUSION

Preemptive gabapentin 300 mg po significantly decreases the severity of pain postoperatively in patients who undergo single-level lumbar discoidectomy.

Authors+Show Affiliations

Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. ckpandey@sgpgi.ac.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15574547

Citation

Pandey, Chandra Kant, et al. "Preemptive Gabapentin Decreases Postoperative Pain After Lumbar Discoidectomy." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 51, no. 10, 2004, pp. 986-9.
Pandey CK, Sahay S, Gupta D, et al. Preemptive gabapentin decreases postoperative pain after lumbar discoidectomy. Can J Anaesth. 2004;51(10):986-9.
Pandey, C. K., Sahay, S., Gupta, D., Ambesh, S. P., Singh, R. B., Raza, M., Singh, U., & Singh, P. K. (2004). Preemptive gabapentin decreases postoperative pain after lumbar discoidectomy. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 51(10), 986-9.
Pandey CK, et al. Preemptive Gabapentin Decreases Postoperative Pain After Lumbar Discoidectomy. Can J Anaesth. 2004;51(10):986-9. PubMed PMID: 15574547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preemptive gabapentin decreases postoperative pain after lumbar discoidectomy. AU - Pandey,Chandra Kant, AU - Sahay,Surabhi, AU - Gupta,Devendra, AU - Ambesh,Sushil Prakash, AU - Singh,Ram Badan, AU - Raza,Mehdi, AU - Singh,Uttam, AU - Singh,Prabhat Kumar, PY - 2004/12/3/pubmed PY - 2005/7/1/medline PY - 2004/12/3/entrez SP - 986 EP - 9 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 51 IS - 10 N2 - PURPOSE: We investigated whether the preemptive use of gabapentin, a structural analogue of gamma amino butyric acid could reduce postoperative pain and fentanyl consumption in patients after single-level lumbar discoidectomy. METHODS: Fifty-six ASA I and II patients were randomly allocated into two equal groups to receive either gabapentin 300 mg or placebo two hours before surgery. After surgery, the pain was assessed on a visual analogue scale (VAS) at intervals of 0-6, 6-12, 12-18, and 18-24 hr at rest. Total fentanyl consumption in the first 24 hr after surgery was also recorded. Fentanyl 2 mug.kg(-1) intravenously was used to treat postoperative pain on patients' demand. RESULTS: Patients in the gabapentin group had significantly lower VAS scores at all time intervals of 0-6, 6-12, 12-18, and 18-24 hr than those in the placebo group (3.5 +/- 2.3, 3.2 +/- 2.1, 1.8 +/- 1.7, 1.2 +/- 1.3 vs 6.1 +/- 1.7, 4.4 +/- 1.2, 3.3 +/- 1.1, 2.1 +/- 1.2; P < 0.05). The total fentanyl consumed after surgery in the first 24 hr in the gabapentin group (233.5 +/- 141.9, mean + SD) was significantly less than in the placebo group (359.6 +/- 104.1; P < 0.05). CONCLUSION: Preemptive gabapentin 300 mg po significantly decreases the severity of pain postoperatively in patients who undergo single-level lumbar discoidectomy. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/15574547/Preemptive_gabapentin_decreases_postoperative_pain_after_lumbar_discoidectomy_ L2 - https://doi.org/10.1007/BF03018484 DB - PRIME DP - Unbound Medicine ER -