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Mustard allergy confirmed by double-blind placebo-controlled food challenges: clinical features and cross-reactivity with mugwort pollen and plant-derived foods.
Allergy. 2005 Jan; 60(1):48-55.A

Abstract

BACKGROUND

Mustard IgE-mediated allergy is supposed to be a rare cause of food allergy, and its clinical features and cross-reactivities have not been fully elucidated.

METHODS

A prospective study was carried out, recruiting mustard allergic patients, and paired control subjects. A clinical questionnaire was administered, and skin-prick tests (SPT) with panels of aeroallergens and foods, serum extraction for in vitro tests and double-blind placebo-controlled food challenges (DBPCFC) were performed.

RESULTS

Thirty-eight mainly adult patients, with 10.5% reporting systemic anaphylaxis, were included in the study [age (mean +/- SD): 21.9 +/- 8.6 years]. DBPCFC were performed in 24 patients, being positive in 14 cases (58.3%). Patients with positive outcome showed significantly greater mustard SPT than those with negative outcome (8.2 +/- 3.7 vs 5.3 +/- 2.4 mm, P <0.05), and the receiver-operating characteristic (ROC) curve analysis yielded a cut-off value for mustard commercial SPT of 8 mm, with a specificity of 90% (95% CI, 55.5-98.3), and a sensitivity of 50% (95% CI, 23.1-76.9). A significant association between mustard hypersensitivity and mugwort pollen sensitization was found (97.4% of patients), with partial cross-reactivity demonstrated by UniCAP System inhibition assays. All patients showed sensitization to other members of Brassicaceae family, and cross-reactivity among them was also confirmed. Moreover, significant associations with nut (97.4%), leguminous (94.7%), corn (78.9%), and Rosaceae fruit (89.5%) sensitizations were also shown. Around 40% of these food sensitizations were symptomatic, including food-dependent exercise-induced anaphylaxis in six patients.

CONCLUSIONS

Mustard allergy is a not-uncommon disorder that can induce severe reactions. Significant associations with mugwort pollinosis and several plant-derived food allergies are demonstrated, suggesting a new mustard-mugwort allergy syndrome. A relationship between this syndrome and food-dependent exercise-induced anaphylaxis is also reported.

Authors+Show Affiliations

Hospital de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15575930

Citation

Figueroa, J, et al. "Mustard Allergy Confirmed By Double-blind Placebo-controlled Food Challenges: Clinical Features and Cross-reactivity With Mugwort Pollen and Plant-derived Foods." Allergy, vol. 60, no. 1, 2005, pp. 48-55.
Figueroa J, Blanco C, Dumpiérrez AG, et al. Mustard allergy confirmed by double-blind placebo-controlled food challenges: clinical features and cross-reactivity with mugwort pollen and plant-derived foods. Allergy. 2005;60(1):48-55.
Figueroa, J., Blanco, C., Dumpiérrez, A. G., Almeida, L., Ortega, N., Castillo, R., Navarro, L., Pérez, E., Gallego, M. D., & Carrillo, T. (2005). Mustard allergy confirmed by double-blind placebo-controlled food challenges: clinical features and cross-reactivity with mugwort pollen and plant-derived foods. Allergy, 60(1), 48-55.
Figueroa J, et al. Mustard Allergy Confirmed By Double-blind Placebo-controlled Food Challenges: Clinical Features and Cross-reactivity With Mugwort Pollen and Plant-derived Foods. Allergy. 2005;60(1):48-55. PubMed PMID: 15575930.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mustard allergy confirmed by double-blind placebo-controlled food challenges: clinical features and cross-reactivity with mugwort pollen and plant-derived foods. AU - Figueroa,J, AU - Blanco,C, AU - Dumpiérrez,A G, AU - Almeida,L, AU - Ortega,N, AU - Castillo,R, AU - Navarro,L, AU - Pérez,E, AU - Gallego,M D, AU - Carrillo,T, PY - 2004/12/4/pubmed PY - 2005/4/6/medline PY - 2004/12/4/entrez SP - 48 EP - 55 JF - Allergy JO - Allergy VL - 60 IS - 1 N2 - BACKGROUND: Mustard IgE-mediated allergy is supposed to be a rare cause of food allergy, and its clinical features and cross-reactivities have not been fully elucidated. METHODS: A prospective study was carried out, recruiting mustard allergic patients, and paired control subjects. A clinical questionnaire was administered, and skin-prick tests (SPT) with panels of aeroallergens and foods, serum extraction for in vitro tests and double-blind placebo-controlled food challenges (DBPCFC) were performed. RESULTS: Thirty-eight mainly adult patients, with 10.5% reporting systemic anaphylaxis, were included in the study [age (mean +/- SD): 21.9 +/- 8.6 years]. DBPCFC were performed in 24 patients, being positive in 14 cases (58.3%). Patients with positive outcome showed significantly greater mustard SPT than those with negative outcome (8.2 +/- 3.7 vs 5.3 +/- 2.4 mm, P <0.05), and the receiver-operating characteristic (ROC) curve analysis yielded a cut-off value for mustard commercial SPT of 8 mm, with a specificity of 90% (95% CI, 55.5-98.3), and a sensitivity of 50% (95% CI, 23.1-76.9). A significant association between mustard hypersensitivity and mugwort pollen sensitization was found (97.4% of patients), with partial cross-reactivity demonstrated by UniCAP System inhibition assays. All patients showed sensitization to other members of Brassicaceae family, and cross-reactivity among them was also confirmed. Moreover, significant associations with nut (97.4%), leguminous (94.7%), corn (78.9%), and Rosaceae fruit (89.5%) sensitizations were also shown. Around 40% of these food sensitizations were symptomatic, including food-dependent exercise-induced anaphylaxis in six patients. CONCLUSIONS: Mustard allergy is a not-uncommon disorder that can induce severe reactions. Significant associations with mugwort pollinosis and several plant-derived food allergies are demonstrated, suggesting a new mustard-mugwort allergy syndrome. A relationship between this syndrome and food-dependent exercise-induced anaphylaxis is also reported. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/15575930/Mustard_allergy_confirmed_by_double_blind_placebo_controlled_food_challenges:_clinical_features_and_cross_reactivity_with_mugwort_pollen_and_plant_derived_foods_ L2 - https://doi.org/10.1111/j.1398-9995.2005.00644.x DB - PRIME DP - Unbound Medicine ER -