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Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK signals.
J Helminthol. 2004 Dec; 78(4):311-7.JH

Abstract

Eosinophilic meningitis or meningoencephalitis caused by Angiostrongylus cantonensis is endemic to the Pacific area of Asia, especially Taiwan, Thailand, and Japan. Although eosinophilia is an important clinical manifestation of A. cantonensis infection, the role of eosinophils in the progress of the infection remains to be elucidated. In this experiment, we show that A. cantonensis-induced eosinophilia and inflammation might lead to the induction of IAP/NF-kappaB, JAK/STAT1 and MEKK1/JNK signals. The phosphorylation levels of JAK and JNK, STAT1, IAP, NF-kappaB and MEKK1 protein products were significantly increased after 12 days or 15 days of A. cantonensis infection. However, no significant differences in MAPKs such as Raf, MEK-1, ERK1/2 and p38 expression were found between control and infected mice. The activation potency of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK started increasing on day 3, with significant induction on day 12 or day 15 after A. cantonensis infection. Consistent results were noted in the pathological observations, including eosinophilia, leukocyte infiltration, granulomatous reactions, and time responses in the brain tissues of infected mice. These data suggest that the development of brain injury by eosinophilia of A. cantonensis infection is associated with activation of JAK/STAT1 signals by cytokines, and/or activation of MEKK1/JNK by oxidant stress, and/or activation of NF-kappaB by increasing IAP expression.

Authors+Show Affiliations

Department of Parasitology, Chung Shan Medical University, 110, Section 1, Chien-Kuo North Road, Taichung 402, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15575987

Citation

Lan, K P., et al. "Induced Eosinophilia and Proliferation in Angiostrongylus Cantonensis-infected Mouse Brain Are Associated With the Induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK Signals." Journal of Helminthology, vol. 78, no. 4, 2004, pp. 311-7.
Lan KP, Wang CJ, Hsu JD, et al. Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK signals. J Helminthol. 2004;78(4):311-7.
Lan, K. P., Wang, C. J., Hsu, J. D., Chen, K. M., Lai, S. C., & Lee, H. H. (2004). Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK signals. Journal of Helminthology, 78(4), 311-7.
Lan KP, et al. Induced Eosinophilia and Proliferation in Angiostrongylus Cantonensis-infected Mouse Brain Are Associated With the Induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK Signals. J Helminthol. 2004;78(4):311-7. PubMed PMID: 15575987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Induced eosinophilia and proliferation in Angiostrongylus cantonensis-infected mouse brain are associated with the induction of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK signals. AU - Lan,K P, AU - Wang,C J, AU - Hsu,J D, AU - Chen,K M, AU - Lai,S C, AU - Lee,H H, PY - 2004/12/4/pubmed PY - 2005/2/4/medline PY - 2004/12/4/entrez SP - 311 EP - 7 JF - Journal of helminthology JO - J Helminthol VL - 78 IS - 4 N2 - Eosinophilic meningitis or meningoencephalitis caused by Angiostrongylus cantonensis is endemic to the Pacific area of Asia, especially Taiwan, Thailand, and Japan. Although eosinophilia is an important clinical manifestation of A. cantonensis infection, the role of eosinophils in the progress of the infection remains to be elucidated. In this experiment, we show that A. cantonensis-induced eosinophilia and inflammation might lead to the induction of IAP/NF-kappaB, JAK/STAT1 and MEKK1/JNK signals. The phosphorylation levels of JAK and JNK, STAT1, IAP, NF-kappaB and MEKK1 protein products were significantly increased after 12 days or 15 days of A. cantonensis infection. However, no significant differences in MAPKs such as Raf, MEK-1, ERK1/2 and p38 expression were found between control and infected mice. The activation potency of JAK/STAT1, IAP/NF-kappaB and MEKK1/JNK started increasing on day 3, with significant induction on day 12 or day 15 after A. cantonensis infection. Consistent results were noted in the pathological observations, including eosinophilia, leukocyte infiltration, granulomatous reactions, and time responses in the brain tissues of infected mice. These data suggest that the development of brain injury by eosinophilia of A. cantonensis infection is associated with activation of JAK/STAT1 signals by cytokines, and/or activation of MEKK1/JNK by oxidant stress, and/or activation of NF-kappaB by increasing IAP expression. SN - 0022-149X UR - https://www.unboundmedicine.com/medline/citation/15575987/Induced_eosinophilia_and_proliferation_in_Angiostrongylus_cantonensis_infected_mouse_brain_are_associated_with_the_induction_of_JAK/STAT1_IAP/NF_kappaB_and_MEKK1/JNK_signals_ L2 - https://www.cambridge.org/core/product/identifier/S0022149X04000514/type/journal_article DB - PRIME DP - Unbound Medicine ER -