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Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease?
Sci Aging Knowledge Environ. 2004 Dec 01; 2004(48):pe42.SA

Abstract

The recent identification of genes (parkin, DJ-1, and PINK1) involved in recessive autosomal parkinsonism, and the indications that these proteins may have protective effects on the mitochondria, has led to the reemergence of the notion that mitochondrial dysfunction might play a central role in the etiology of sporadic Parkinson's disease (PD). This idea has previously been supported by biochemical analyses showing reduced mitochondrial activity in PD patients and in animal models of PD generated by the selective inhibition of mitochondria activity. However, the involvement of DJ-1 or PINK1 loss of function in classical idiopathic PD, characterized by pathological inclusions composed of aggregated alpha-synuclein protein, has still not been evaluated. More detailed studies of the possible interactions between parkin, DJ-1, PINK1, and alpha-synuclein and their effects on mitochondria are needed to more adequately define the biological pathways that may convergently or independently lead to parkinsonism.

Authors+Show Affiliations

Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. giassonb@mail.med.upenn.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15576821

Citation

Giasson, Benoit I.. "Mitochondrial Injury: a Hot Spot for Parkinsonism and Parkinson's Disease?" Science of Aging Knowledge Environment : SAGE KE, vol. 2004, no. 48, 2004, pp. pe42.
Giasson BI. Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease? Sci Aging Knowledge Environ. 2004;2004(48):pe42.
Giasson, B. I. (2004). Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease? Science of Aging Knowledge Environment : SAGE KE, 2004(48), pe42.
Giasson BI. Mitochondrial Injury: a Hot Spot for Parkinsonism and Parkinson's Disease. Sci Aging Knowledge Environ. 2004 Dec 1;2004(48):pe42. PubMed PMID: 15576821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease? A1 - Giasson,Benoit I, Y1 - 2004/12/01/ PY - 2004/12/4/pubmed PY - 2005/10/12/medline PY - 2004/12/4/entrez SP - pe42 EP - pe42 JF - Science of aging knowledge environment : SAGE KE JO - Sci Aging Knowledge Environ VL - 2004 IS - 48 N2 - The recent identification of genes (parkin, DJ-1, and PINK1) involved in recessive autosomal parkinsonism, and the indications that these proteins may have protective effects on the mitochondria, has led to the reemergence of the notion that mitochondrial dysfunction might play a central role in the etiology of sporadic Parkinson's disease (PD). This idea has previously been supported by biochemical analyses showing reduced mitochondrial activity in PD patients and in animal models of PD generated by the selective inhibition of mitochondria activity. However, the involvement of DJ-1 or PINK1 loss of function in classical idiopathic PD, characterized by pathological inclusions composed of aggregated alpha-synuclein protein, has still not been evaluated. More detailed studies of the possible interactions between parkin, DJ-1, PINK1, and alpha-synuclein and their effects on mitochondria are needed to more adequately define the biological pathways that may convergently or independently lead to parkinsonism. SN - 1539-6150 UR - https://www.unboundmedicine.com/medline/citation/15576821/Mitochondrial_injury:_a_hot_spot_for_parkinsonism_and_Parkinson's_disease L2 - http://sageke.sciencemag.org/cgi/pmidlookup?view=long&pmid=15576821 DB - PRIME DP - Unbound Medicine ER -
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