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[Sevelamer hydrochloride prevents ectopic calcification of blood vessels].
Clin Calcium. 2004 Jun; 14(6):116-22.CC

Abstract

Sevelamer hydrochloride is a non-absorbed calcium- and metal-free phosphate binder that lowers the serum phosphorus levels in hemodialysis patients. Sevelamer contains multiple amines, which are partially protonated and interact with phosphate molecules through ionic and hydrogen bonding. We show the in vitro phosphate binding assay data and the efficacy of sevelamer to lower the serum phosphorus and calcium phosphorus product in several animal models. Furthermore, we indicate the vivid data that sevelamer prevented the ectopic calcification of aorta in adenine induced renal failure model, which represent severe hyperphosphatemia and the related dialysis complications.

Authors+Show Affiliations

Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co., Ltd.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

jpn

PubMed ID

15577065

Citation

Fukushima, Naoshi, and Nobuo Nagano. "[Sevelamer Hydrochloride Prevents Ectopic Calcification of Blood Vessels]." Clinical Calcium, vol. 14, no. 6, 2004, pp. 116-22.
Fukushima N, Nagano N. [Sevelamer hydrochloride prevents ectopic calcification of blood vessels]. Clin Calcium. 2004;14(6):116-22.
Fukushima, N., & Nagano, N. (2004). [Sevelamer hydrochloride prevents ectopic calcification of blood vessels]. Clinical Calcium, 14(6), 116-22.
Fukushima N, Nagano N. [Sevelamer Hydrochloride Prevents Ectopic Calcification of Blood Vessels]. Clin Calcium. 2004;14(6):116-22. PubMed PMID: 15577065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Sevelamer hydrochloride prevents ectopic calcification of blood vessels]. AU - Fukushima,Naoshi, AU - Nagano,Nobuo, PY - 2004/12/4/pubmed PY - 2005/2/11/medline PY - 2004/12/4/entrez SP - 116 EP - 22 JF - Clinical calcium JO - Clin Calcium VL - 14 IS - 6 N2 - Sevelamer hydrochloride is a non-absorbed calcium- and metal-free phosphate binder that lowers the serum phosphorus levels in hemodialysis patients. Sevelamer contains multiple amines, which are partially protonated and interact with phosphate molecules through ionic and hydrogen bonding. We show the in vitro phosphate binding assay data and the efficacy of sevelamer to lower the serum phosphorus and calcium phosphorus product in several animal models. Furthermore, we indicate the vivid data that sevelamer prevented the ectopic calcification of aorta in adenine induced renal failure model, which represent severe hyperphosphatemia and the related dialysis complications. SN - 0917-5857 UR - https://www.unboundmedicine.com/medline/citation/15577065/[Sevelamer_hydrochloride_prevents_ectopic_calcification_of_blood_vessels]_ DB - PRIME DP - Unbound Medicine ER -