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Reducing major cause-specific hospitalization rates and shortening hospital stays after influenza vaccination.
Clin Infect Dis. 2004 Dec 01; 39(11):1604-10.CI

Abstract

BACKGROUND

The impact of influenza vaccination on major cause-specific hospitalization and the duration of hospital stay is rarely reported. Our purpose was to study the effect of vaccine efficacy on major disease-specific hospitalization and the duration of hospital stays among elderly persons.

SUBJECTS AND METHODS

From 1 January through 30 June 2001, we prospectively observed 35,637 vaccinated elderly persons (age, >or=65 years) and 53,094 unvaccinated elderly persons in Kaohsiung County, Taiwan, by computerized linkage to the National Health Insurance database. Of these persons, 21,347 had been assigned a high-risk status by the Department of Health, Taiwan. Univariate and multivariate logistic regression were used for determining vaccine efficacy in hospitalization. Multiple linear regression analyses were performed for determining the length of hospital stays.

RESULTS

In both high-risk and low-risk groups, vaccination was associated with reducing the rates of hospitalization for all causes (20% vs. 23%), lung diseases, congestive heart failure (43% vs. 32%), renal disease, and liver disease (P<.05). It was also significant for stroke, hypertension, diabetes, neoplasm, and injury in low-risk patients (P<.05). Multivariate logistic regression showed that vaccination was significantly associated with reducing the rate of hospitalization (odds ratio [OR], 0.89; 95% confidence interval [CI], 0.86-0.92), but those with high-risk status had an increased risk of hospitalization (OR, 3.69; 95% CI, 3.56-3.82). Multiple linear regression analysis showed that vaccination decreased the duration of all-cause hospital stays (coefficient, -2.4 days; 95% CI, -2.7 to -2.1 days) and of hospitalization due to lung disease (coefficient, -4.9 days; 95% CI, -6.0 to -3.8 days).

CONCLUSION

Influenza vaccination may reduce hospitalization rates and shorten hospital stays not only for lung diseases but also for other common diseases in high-risk and low-risk elderly populations.

Authors+Show Affiliations

Community Medicine Research Center and Institute of Public Health, National Yang-Ming University, Shih-Pai, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15578359

Citation

Wang, Chong-Shan, et al. "Reducing Major Cause-specific Hospitalization Rates and Shortening Hospital Stays After Influenza Vaccination." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 39, no. 11, 2004, pp. 1604-10.
Wang CS, Wang ST, Lai CT, et al. Reducing major cause-specific hospitalization rates and shortening hospital stays after influenza vaccination. Clin Infect Dis. 2004;39(11):1604-10.
Wang, C. S., Wang, S. T., Lai, C. T., Lin, L. J., Lee, C. T., & Chou, P. (2004). Reducing major cause-specific hospitalization rates and shortening hospital stays after influenza vaccination. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 39(11), 1604-10.
Wang CS, et al. Reducing Major Cause-specific Hospitalization Rates and Shortening Hospital Stays After Influenza Vaccination. Clin Infect Dis. 2004 Dec 1;39(11):1604-10. PubMed PMID: 15578359.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reducing major cause-specific hospitalization rates and shortening hospital stays after influenza vaccination. AU - Wang,Chong-Shan, AU - Wang,Shan-Tair, AU - Lai,Ching-Te, AU - Lin,Li-Jen, AU - Lee,Chien-Ting, AU - Chou,Pesus, Y1 - 2004/11/10/ PY - 2004/05/24/received PY - 2004/06/23/accepted PY - 2004/12/4/pubmed PY - 2005/11/9/medline PY - 2004/12/4/entrez SP - 1604 EP - 10 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 39 IS - 11 N2 - BACKGROUND: The impact of influenza vaccination on major cause-specific hospitalization and the duration of hospital stay is rarely reported. Our purpose was to study the effect of vaccine efficacy on major disease-specific hospitalization and the duration of hospital stays among elderly persons. SUBJECTS AND METHODS: From 1 January through 30 June 2001, we prospectively observed 35,637 vaccinated elderly persons (age, >or=65 years) and 53,094 unvaccinated elderly persons in Kaohsiung County, Taiwan, by computerized linkage to the National Health Insurance database. Of these persons, 21,347 had been assigned a high-risk status by the Department of Health, Taiwan. Univariate and multivariate logistic regression were used for determining vaccine efficacy in hospitalization. Multiple linear regression analyses were performed for determining the length of hospital stays. RESULTS: In both high-risk and low-risk groups, vaccination was associated with reducing the rates of hospitalization for all causes (20% vs. 23%), lung diseases, congestive heart failure (43% vs. 32%), renal disease, and liver disease (P<.05). It was also significant for stroke, hypertension, diabetes, neoplasm, and injury in low-risk patients (P<.05). Multivariate logistic regression showed that vaccination was significantly associated with reducing the rate of hospitalization (odds ratio [OR], 0.89; 95% confidence interval [CI], 0.86-0.92), but those with high-risk status had an increased risk of hospitalization (OR, 3.69; 95% CI, 3.56-3.82). Multiple linear regression analysis showed that vaccination decreased the duration of all-cause hospital stays (coefficient, -2.4 days; 95% CI, -2.7 to -2.1 days) and of hospitalization due to lung disease (coefficient, -4.9 days; 95% CI, -6.0 to -3.8 days). CONCLUSION: Influenza vaccination may reduce hospitalization rates and shorten hospital stays not only for lung diseases but also for other common diseases in high-risk and low-risk elderly populations. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/15578359/Reducing_major_cause_specific_hospitalization_rates_and_shortening_hospital_stays_after_influenza_vaccination_ L2 - https://academic.oup.com/cid/article-lookup/doi/10.1086/425323 DB - PRIME DP - Unbound Medicine ER -