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The relationship between C-reactive protein and carotid intima-media wall thickness in middle-aged women with polycystic ovary syndrome.
J Clin Endocrinol Metab. 2004 Dec; 89(12):6061-7.JC

Abstract

Polycystic ovary syndrome (PCOS) is associated with premature carotid atherosclerosis. C-Reactive protein (CRP) has been implicated as a vascular disease risk factor. The objective of this study was to determine whether elevated CRP is associated with increased carotid intima-media wall thickness (IMT) in PCOS women. Forty-seven PCOS patients and 59 similarly aged controls were screened for cardiovascular risk factors and concurrently underwent carotid ultrasonography (1996-1999). The main outcome measure was carotid IMT. CRP was significantly higher in PCOS patients than in controls (3.4 vs. 2.1 mg/dl; P = 0.002). In regression modeling, PCOS associated with IMT independently of CRP and age (P = 0.019). Body mass index reduced the association of PCOS and CRP with IMT and was also associated with IMT (P = 0.029). The CRP-IMT relationship was attenuated when either insulin or visceral fat was included in the PCOS-age-CRP model (P = 0.197 and P = 0.550, respectively). PCOS remained associated with IMT independent of insulin (P = 0.033) or visceral fat (P = 0.040). CRP does not appreciably mediate the effect of PCOS on IMT. Obesity partially explained the influence of PCOS and CRP on IMT. The effect of body mass index on the PCOS-IMT relationship was not completely determined by hyperinsulinemia or visceral fat, and might be mediated by other aspects of PCOS-related adiposity.

Authors+Show Affiliations

Talbott EO
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA. eot1@pitt.edu
Zborowski JV
No affiliation info available
Boudreaux MY
No affiliation info available
McHugh-Pemu KP
No affiliation info available
Sutton-Tyrrell K
No affiliation info available
Guzick DS
No affiliation info available

MeSH

Body Mass IndexC-Reactive ProteinCardiovascular DiseasesCarotid ArteriesCase-Control StudiesCross-Sectional StudiesFemaleHormonesHumansMiddle AgedPolycystic Ovary SyndromeRisk FactorsSingle-Blind MethodTunica IntimaTunica MediaUltrasonography

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15579759

Clinical Trial Links

Risk of Coronary Heart Disease in Women With Polycystic Ovary Syndrome

Citation

Talbott, E O., et al. "The Relationship Between C-reactive Protein and Carotid Intima-media Wall Thickness in Middle-aged Women With Polycystic Ovary Syndrome." The Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 12, 2004, pp. 6061-7.
Talbott EO, Zborowski JV, Boudreaux MY, et al. The relationship between C-reactive protein and carotid intima-media wall thickness in middle-aged women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2004;89(12):6061-7.
Talbott, E. O., Zborowski, J. V., Boudreaux, M. Y., McHugh-Pemu, K. P., Sutton-Tyrrell, K., & Guzick, D. S. (2004). The relationship between C-reactive protein and carotid intima-media wall thickness in middle-aged women with polycystic ovary syndrome. The Journal of Clinical Endocrinology and Metabolism, 89(12), 6061-7.
Talbott EO, et al. The Relationship Between C-reactive Protein and Carotid Intima-media Wall Thickness in Middle-aged Women With Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2004;89(12):6061-7. PubMed PMID: 15579759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between C-reactive protein and carotid intima-media wall thickness in middle-aged women with polycystic ovary syndrome. AU - Talbott,E O, AU - Zborowski,J V, AU - Boudreaux,M Y, AU - McHugh-Pemu,K P, AU - Sutton-Tyrrell,K, AU - Guzick,D S, PY - 2004/12/8/pubmed PY - 2005/2/4/medline PY - 2004/12/8/entrez SP - 6061 EP - 7 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 89 IS - 12 N2 - Polycystic ovary syndrome (PCOS) is associated with premature carotid atherosclerosis. C-Reactive protein (CRP) has been implicated as a vascular disease risk factor. The objective of this study was to determine whether elevated CRP is associated with increased carotid intima-media wall thickness (IMT) in PCOS women. Forty-seven PCOS patients and 59 similarly aged controls were screened for cardiovascular risk factors and concurrently underwent carotid ultrasonography (1996-1999). The main outcome measure was carotid IMT. CRP was significantly higher in PCOS patients than in controls (3.4 vs. 2.1 mg/dl; P = 0.002). In regression modeling, PCOS associated with IMT independently of CRP and age (P = 0.019). Body mass index reduced the association of PCOS and CRP with IMT and was also associated with IMT (P = 0.029). The CRP-IMT relationship was attenuated when either insulin or visceral fat was included in the PCOS-age-CRP model (P = 0.197 and P = 0.550, respectively). PCOS remained associated with IMT independent of insulin (P = 0.033) or visceral fat (P = 0.040). CRP does not appreciably mediate the effect of PCOS on IMT. Obesity partially explained the influence of PCOS and CRP on IMT. The effect of body mass index on the PCOS-IMT relationship was not completely determined by hyperinsulinemia or visceral fat, and might be mediated by other aspects of PCOS-related adiposity. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/15579759/The_relationship_between_C_reactive_protein_and_carotid_intima_media_wall_thickness_in_middle_aged_women_with_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -
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