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The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis.
Rheumatol Int 2005; 26(2):137-41RI

Abstract

OBJECTIVE

Oxidative stress and inflammatory processes accelerate the formation of advanced glycation end products (AGE), e.g. of pentosidine. The aim of this study was to investigate the relationships between levels of pentosidine in serum and synovial fluid, proinflammatory cytokines, other markers of inflammatory activity, and the state of radiologically visible bone destruction in patients with rheumatoid arthritis (RA).

OBJECTIVES

One hundred thirty-three nondiabetic RA patients and 56 age-matched, healthy subjects were included. Serum and synovial fluid pentosidine, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor levels were determined. In 30 patients, the proinflammatory cytokines interleukin (IL)-1beta, IL-6, and TNF-alpha and the soluble receptors sIL-2R, sIL-6R, sTNF-alpha, and RI/RII were also measured.

RESULTS

Serum levels of pentosidine were on average significantly higher in RA patients than in healthy subjects and correlated significantly to ESR, CRP, and serum levels of IL-6. Serum and synovial fluid pentosidine did not show any differences. Rheumatoid factor-positive RA patients had higher pentosidine levels in the synovial fluid than rheumatoid factor-negative patients. Correlations could not be found between pentosidine and the other cytokines or cytokine receptors measured.

CONCLUSION

The binding of AGE on cell receptors induces activation of nuclear factor kappa B, resulting in enhanced synthesis of proinflammatory cytokines. Moreover, AGE generation may also lead to the formation of new, immunologically relevant epitopes at synovial proteins. Both mechanisms could contribute to initiation and perpetuation of the inflammatory and destructive processes in RA.

Authors+Show Affiliations

Rheumatology and Osteology, Department of Internal Medicine III, Friedrich Schiller University of Jena, 07740 Jena, Germany. gert.hein@med.uni-jena.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15580352

Citation

Hein, Gert E., et al. "The Advanced Glycation End Product Pentosidine Correlates to IL-6 and Other Relevant Inflammatory Markers in Rheumatoid Arthritis." Rheumatology International, vol. 26, no. 2, 2005, pp. 137-41.
Hein GE, Köhler M, Oelzner P, et al. The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis. Rheumatol Int. 2005;26(2):137-41.
Hein, G. E., Köhler, M., Oelzner, P., Stein, G., & Franke, S. (2005). The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis. Rheumatology International, 26(2), pp. 137-41.
Hein GE, et al. The Advanced Glycation End Product Pentosidine Correlates to IL-6 and Other Relevant Inflammatory Markers in Rheumatoid Arthritis. Rheumatol Int. 2005;26(2):137-41. PubMed PMID: 15580352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The advanced glycation end product pentosidine correlates to IL-6 and other relevant inflammatory markers in rheumatoid arthritis. AU - Hein,Gert E, AU - Köhler,Markus, AU - Oelzner,Peter, AU - Stein,Günter, AU - Franke,Sybille, Y1 - 2004/12/03/ PY - 2004/03/22/received PY - 2004/07/25/accepted PY - 2004/12/8/pubmed PY - 2006/9/13/medline PY - 2004/12/8/entrez SP - 137 EP - 41 JF - Rheumatology international JO - Rheumatol. Int. VL - 26 IS - 2 N2 - OBJECTIVE: Oxidative stress and inflammatory processes accelerate the formation of advanced glycation end products (AGE), e.g. of pentosidine. The aim of this study was to investigate the relationships between levels of pentosidine in serum and synovial fluid, proinflammatory cytokines, other markers of inflammatory activity, and the state of radiologically visible bone destruction in patients with rheumatoid arthritis (RA). OBJECTIVES: One hundred thirty-three nondiabetic RA patients and 56 age-matched, healthy subjects were included. Serum and synovial fluid pentosidine, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and rheumatoid factor levels were determined. In 30 patients, the proinflammatory cytokines interleukin (IL)-1beta, IL-6, and TNF-alpha and the soluble receptors sIL-2R, sIL-6R, sTNF-alpha, and RI/RII were also measured. RESULTS: Serum levels of pentosidine were on average significantly higher in RA patients than in healthy subjects and correlated significantly to ESR, CRP, and serum levels of IL-6. Serum and synovial fluid pentosidine did not show any differences. Rheumatoid factor-positive RA patients had higher pentosidine levels in the synovial fluid than rheumatoid factor-negative patients. Correlations could not be found between pentosidine and the other cytokines or cytokine receptors measured. CONCLUSION: The binding of AGE on cell receptors induces activation of nuclear factor kappa B, resulting in enhanced synthesis of proinflammatory cytokines. Moreover, AGE generation may also lead to the formation of new, immunologically relevant epitopes at synovial proteins. Both mechanisms could contribute to initiation and perpetuation of the inflammatory and destructive processes in RA. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/15580352/The_advanced_glycation_end_product_pentosidine_correlates_to_IL_6_and_other_relevant_inflammatory_markers_in_rheumatoid_arthritis_ L2 - https://dx.doi.org/10.1007/s00296-004-0518-1 DB - PRIME DP - Unbound Medicine ER -