Tags

Type your tag names separated by a space and hit enter

Telomerase activity in thyroid fine needle aspirates.
Acta Cytol. 2004 Nov-Dec; 48(6):818-24.AC

Abstract

OBJECTIVE

To study the utility of telomerase activity (TA) detection in thyroid fine needle aspirates (FNAs).

STUDY DESIGN

One hundred two thyroid nodules were studied: 70 in FNA samples and 32 in frozen tumors. From among FNA samples, there were 57 nodules of the goiter, 1 adenoma, 7 papillary carcinomas, 1 medullary carcinoma and 1 lymphoma. Three cases of thyroiditis were excluded. The 32 frozen tissue tumors consisted of 5 follicular adenomas, 4 follicular carcinomas and 23 papillary carcinomas. TA was analyzed by Telomerase PCR ELISA (Roche Diagnostics, Indianapolis, Indiana, U.S.A.).

RESULTS

TA was negative in the 57 nonneoplastic nodules and 6 follicular adenomas and positive in 3 of 4 follicular carcinomas and 10 of 30 papillary carcinomas. TA sensitivity was 41.4% and specificity 100%. Sensitivity for malignancy was higher (85.7%) in FNAs than in TA.

CONCLUSION

TA seems highly specific for neoplasms of the thyroid. Further studies are needed to confirm whether TA detection could contribute to identifying neoplasms when FNAs are inconclusive for malignancy and in cases of scanty material.

Authors+Show Affiliations

Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University, Barcelona, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15581168

Citation

Mora, Josefina, et al. "Telomerase Activity in Thyroid Fine Needle Aspirates." Acta Cytologica, vol. 48, no. 6, 2004, pp. 818-24.
Mora J, Lerma E, Thyroid Neoplasia Study Group. Telomerase activity in thyroid fine needle aspirates. Acta Cytol. 2004;48(6):818-24.
Mora, J., & Lerma, E. (2004). Telomerase activity in thyroid fine needle aspirates. Acta Cytologica, 48(6), 818-24.
Mora J, Lerma E, Thyroid Neoplasia Study Group. Telomerase Activity in Thyroid Fine Needle Aspirates. Acta Cytol. 2004 Nov-Dec;48(6):818-24. PubMed PMID: 15581168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomerase activity in thyroid fine needle aspirates. AU - Mora,Josefina, AU - Lerma,Enrique, AU - ,, PY - 2004/12/8/pubmed PY - 2005/1/19/medline PY - 2004/12/8/entrez SP - 818 EP - 24 JF - Acta cytologica JO - Acta Cytol VL - 48 IS - 6 N2 - OBJECTIVE: To study the utility of telomerase activity (TA) detection in thyroid fine needle aspirates (FNAs). STUDY DESIGN: One hundred two thyroid nodules were studied: 70 in FNA samples and 32 in frozen tumors. From among FNA samples, there were 57 nodules of the goiter, 1 adenoma, 7 papillary carcinomas, 1 medullary carcinoma and 1 lymphoma. Three cases of thyroiditis were excluded. The 32 frozen tissue tumors consisted of 5 follicular adenomas, 4 follicular carcinomas and 23 papillary carcinomas. TA was analyzed by Telomerase PCR ELISA (Roche Diagnostics, Indianapolis, Indiana, U.S.A.). RESULTS: TA was negative in the 57 nonneoplastic nodules and 6 follicular adenomas and positive in 3 of 4 follicular carcinomas and 10 of 30 papillary carcinomas. TA sensitivity was 41.4% and specificity 100%. Sensitivity for malignancy was higher (85.7%) in FNAs than in TA. CONCLUSION: TA seems highly specific for neoplasms of the thyroid. Further studies are needed to confirm whether TA detection could contribute to identifying neoplasms when FNAs are inconclusive for malignancy and in cases of scanty material. SN - 0001-5547 UR - https://www.unboundmedicine.com/medline/citation/15581168/Telomerase_activity_in_thyroid_fine_needle_aspirates_ L2 - https://www.karger.com?DOI=10.1159/000326452 DB - PRIME DP - Unbound Medicine ER -