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Scanning laser polarimetry of the retinal nerve fiber layer in perimetrically unaffected eyes of glaucoma patients.
Ophthalmology 2004; 111(12):2199-203O

Abstract

PURPOSE

To compare scanning laser polarimetry (SLP) measurements of retinal nerve fiber layer (RNFL) thickness in perimetrically unaffected eyes of glaucoma patients with those in their fellow eyes with field loss and eyes of healthy subjects.

DESIGN

Observational case-control study.

PARTICIPANTS AND CONTROLS

Twenty-three glaucoma patients with a reproducible visual field (VF) defect in one eye (mean mean deviation [MD], -5.71 decibels [dB]) and a normal VF in the other one (i.e., < or =1 VF test point below the 5% probability level [mean MD, -0.01 dB]) and 73 control eyes of as many age-matched healthy subjects (mean MD, 0.39 dB). The MDs and pattern standard deviations of the glaucoma patients' eyes with normal VFs and the control eyes did not statistically significantly differ (independent samples t test, P = 0.15 and P = 0.61, respectively).

METHODS

All subjects were measured in both eyes with the GDxVCC, a commercially available instrument featuring SLP with automated variable corneal compensation. Standard automated perimetry was assessed by means of the Humphrey Field Analyzer (24-2 Full Threshold or Swedish interactive threshold algorithm Standard achromatic test program).

MAIN OUTCOME MEASURES

The standard GDxVCC parameters TSNIT (temporal, superior, nasal, inferior, temporal) Average, Superior Average, Inferior Average, TSNIT Std. Dev., and Nerve Fiber Indicator (NFI) were determined. We also assessed the thickness values in 6 parapapillary sectors. In addition, we calculated the proportion of eyes per group with an NFI of > or =40.

RESULTS

GDxVCC measurements showed more RNFL thinning in the perimetrically unaffected eyes of glaucoma patients than in the healthy control eyes. The RNFL in the perimetrically unaffected eyes of glaucoma patients was thicker than that in their fellow eyes with field loss. The NFI had a value of > or =40 in 11 of 23 (47.8%) perimetrically unaffected eyes of glaucoma patients, 19 of 23 (82.6%) eyes with VF loss of glaucoma patients, and 3 of 73 (4.1%) healthy control eyes.

CONCLUSION

With the GDxVCC, thinning of the RNFL may be detected in perimetrically unaffected eyes of glaucoma patients with field loss in their fellow eyes.

Links

  • Publisher Full Text

    • Authors+Show Affiliations

    Reus NJ
    Glaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands. reus@oogziekenhuis.nl
    Lemij HG
    No affiliation info available

    MeSH

    AdultAgedAged, 80 and overCase-Control StudiesDiagnostic Techniques, OphthalmologicalFemaleGlaucoma, Open-AngleHumansIntraocular PressureLasersMaleMiddle AgedNerve FibersOptic Nerve DiseasesRetinal Ganglion CellsTonometry, OcularVision DisordersVisual Field TestsVisual Fields

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15582074

    Citation

    Reus, Nicolaas J., and Hans G. Lemij. "Scanning Laser Polarimetry of the Retinal Nerve Fiber Layer in Perimetrically Unaffected Eyes of Glaucoma Patients." Ophthalmology, vol. 111, no. 12, 2004, pp. 2199-203.
    Reus NJ, Lemij HG. Scanning laser polarimetry of the retinal nerve fiber layer in perimetrically unaffected eyes of glaucoma patients. Ophthalmology. 2004;111(12):2199-203.
    Reus, N. J., & Lemij, H. G. (2004). Scanning laser polarimetry of the retinal nerve fiber layer in perimetrically unaffected eyes of glaucoma patients. Ophthalmology, 111(12), pp. 2199-203.
    Reus NJ, Lemij HG. Scanning Laser Polarimetry of the Retinal Nerve Fiber Layer in Perimetrically Unaffected Eyes of Glaucoma Patients. Ophthalmology. 2004;111(12):2199-203. PubMed PMID: 15582074.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Scanning laser polarimetry of the retinal nerve fiber layer in perimetrically unaffected eyes of glaucoma patients. AU - Reus,Nicolaas J, AU - Lemij,Hans G, PY - 2004/02/19/received PY - 2004/06/11/accepted PY - 2004/12/8/pubmed PY - 2004/12/21/medline PY - 2004/12/8/entrez SP - 2199 EP - 203 JF - Ophthalmology JO - Ophthalmology VL - 111 IS - 12 N2 - PURPOSE: To compare scanning laser polarimetry (SLP) measurements of retinal nerve fiber layer (RNFL) thickness in perimetrically unaffected eyes of glaucoma patients with those in their fellow eyes with field loss and eyes of healthy subjects. DESIGN: Observational case-control study. PARTICIPANTS AND CONTROLS: Twenty-three glaucoma patients with a reproducible visual field (VF) defect in one eye (mean mean deviation [MD], -5.71 decibels [dB]) and a normal VF in the other one (i.e., < or =1 VF test point below the 5% probability level [mean MD, -0.01 dB]) and 73 control eyes of as many age-matched healthy subjects (mean MD, 0.39 dB). The MDs and pattern standard deviations of the glaucoma patients' eyes with normal VFs and the control eyes did not statistically significantly differ (independent samples t test, P = 0.15 and P = 0.61, respectively). METHODS: All subjects were measured in both eyes with the GDxVCC, a commercially available instrument featuring SLP with automated variable corneal compensation. Standard automated perimetry was assessed by means of the Humphrey Field Analyzer (24-2 Full Threshold or Swedish interactive threshold algorithm Standard achromatic test program). MAIN OUTCOME MEASURES: The standard GDxVCC parameters TSNIT (temporal, superior, nasal, inferior, temporal) Average, Superior Average, Inferior Average, TSNIT Std. Dev., and Nerve Fiber Indicator (NFI) were determined. We also assessed the thickness values in 6 parapapillary sectors. In addition, we calculated the proportion of eyes per group with an NFI of > or =40. RESULTS: GDxVCC measurements showed more RNFL thinning in the perimetrically unaffected eyes of glaucoma patients than in the healthy control eyes. The RNFL in the perimetrically unaffected eyes of glaucoma patients was thicker than that in their fellow eyes with field loss. The NFI had a value of > or =40 in 11 of 23 (47.8%) perimetrically unaffected eyes of glaucoma patients, 19 of 23 (82.6%) eyes with VF loss of glaucoma patients, and 3 of 73 (4.1%) healthy control eyes. CONCLUSION: With the GDxVCC, thinning of the RNFL may be detected in perimetrically unaffected eyes of glaucoma patients with field loss in their fellow eyes. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/15582074/Scanning_laser_polarimetry_of_the_retinal_nerve_fiber_layer_in_perimetrically_unaffected_eyes_of_glaucoma_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(04)00963-7 DB - PRIME DP - Unbound Medicine ER -