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Behavioural sensitisation following repeated intermittent oral administration of Catha edulis in rats.
Behav Brain Res. 2005 Jan 30; 156(2):181-9.BB

Abstract

A prolonged use of psychostimulants has been suggested to induce long-lasting behavioural sensitisation which plays a role in the acquisition and maintenance of addictive behaviour. A study was conducted to evaluate the effect of repeated oral administration of Catha edulis in rats. Male Sprague-Dawley rats divided into five groups received: saline, S-(-)-cathinone (1.5 mg/kg), D-(+)-amphetamine (1.5 mg/kg) and standardized C. edulis extract (50 or 200 mg/kg) once daily for nine consecutive days and later challenged with the same psychostimulants after five abstinence days. Then, 2 weeks later, rats were decapitated and the level of neurotransmitters were assessed. Behavioural activities were monitored using activity and sniffing boxes. The results demonstrated that the three psychostimulants induced strong behavioural sensitisation in rats. Whereas, neurotransmitters analyses showed no significant changes in the basal level of dopamine in most of the regions except that C. edulis extract (200 mg/kg) significantly reduced the level of DA, DOPAC and HVA in the anterior caudate putamen (P < 0.05). The capacity of C. edulis to elicit a long-lasting behavioural sensitisation support the anecdotal literatures about psychiatric problems associated with C. edulis chewing.

Authors+Show Affiliations

Department of Neuropharmacology, Zoological Institute, University of Tübingen Auf der Morgenstelle 28E, 72076 Tübingen, Germany. mybanjaw67@yahoo.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15582104

Citation

Banjaw, Mehret Yerdaw, and Werner J. Schmidt. "Behavioural Sensitisation Following Repeated Intermittent Oral Administration of Catha Edulis in Rats." Behavioural Brain Research, vol. 156, no. 2, 2005, pp. 181-9.
Banjaw MY, Schmidt WJ. Behavioural sensitisation following repeated intermittent oral administration of Catha edulis in rats. Behav Brain Res. 2005;156(2):181-9.
Banjaw, M. Y., & Schmidt, W. J. (2005). Behavioural sensitisation following repeated intermittent oral administration of Catha edulis in rats. Behavioural Brain Research, 156(2), 181-9.
Banjaw MY, Schmidt WJ. Behavioural Sensitisation Following Repeated Intermittent Oral Administration of Catha Edulis in Rats. Behav Brain Res. 2005 Jan 30;156(2):181-9. PubMed PMID: 15582104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioural sensitisation following repeated intermittent oral administration of Catha edulis in rats. AU - Banjaw,Mehret Yerdaw, AU - Schmidt,Werner J, PY - 2004/05/03/received PY - 2004/05/15/revised PY - 2004/05/17/accepted PY - 2004/12/8/pubmed PY - 2005/3/8/medline PY - 2004/12/8/entrez SP - 181 EP - 9 JF - Behavioural brain research JO - Behav. Brain Res. VL - 156 IS - 2 N2 - A prolonged use of psychostimulants has been suggested to induce long-lasting behavioural sensitisation which plays a role in the acquisition and maintenance of addictive behaviour. A study was conducted to evaluate the effect of repeated oral administration of Catha edulis in rats. Male Sprague-Dawley rats divided into five groups received: saline, S-(-)-cathinone (1.5 mg/kg), D-(+)-amphetamine (1.5 mg/kg) and standardized C. edulis extract (50 or 200 mg/kg) once daily for nine consecutive days and later challenged with the same psychostimulants after five abstinence days. Then, 2 weeks later, rats were decapitated and the level of neurotransmitters were assessed. Behavioural activities were monitored using activity and sniffing boxes. The results demonstrated that the three psychostimulants induced strong behavioural sensitisation in rats. Whereas, neurotransmitters analyses showed no significant changes in the basal level of dopamine in most of the regions except that C. edulis extract (200 mg/kg) significantly reduced the level of DA, DOPAC and HVA in the anterior caudate putamen (P < 0.05). The capacity of C. edulis to elicit a long-lasting behavioural sensitisation support the anecdotal literatures about psychiatric problems associated with C. edulis chewing. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/15582104/Behavioural_sensitisation_following_repeated_intermittent_oral_administration_of_Catha_edulis_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(04)00188-3 DB - PRIME DP - Unbound Medicine ER -