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Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period.
Pharmacol Biochem Behav 2004; 79(4):723-31PB

Abstract

3,4-Methylenedioxymethamphetamine (MDMA, or "Ecstasy") is a popular recreational drug among adolescents that is often taken primarily on weekends. The goals of this study were to develop a model of the typical intermittent pattern of human MDMA use in periadolescent rats and to determine the behavioral consequences of MDMA exposure in this model. Male Sprague-Dawley rats received s.c. injections of 10 mg/kg of MDMA or saline twice daily with an interdose interval of 4 h. Treatments were given every fifth day from postnatal day (PD) 35 to PD 60. Beginning at PD 65, the animals were tested for open-field activity, object recognition memory, and anxiety-related behaviors in the elevated plus-maze. Brain tissues were collected at PD 70 for determination of radiolabeled paroxetine binding to the serotonin transporter (SERT) in the neocortex and hippocampus. Repeated MDMA administration led to a reduced rate of weight gain that was evident by PD 50. There was no treatment effect on ambulatory behavior in the open-field. However, the MDMA group displayed an impairment of object recognition memory and reduced anxiety as indicated by a twofold increase in open-arm duration in the elevated plus-maze. Only modest decreases in SERT binding were observed, although there was a significant negative correlation between hippocampal SERT levels and open-arm duration within the MDMA group. These findings demonstrate that intermittent MDMA exposure during the adolescent period of development can influence subsequent cognitive and affective functioning in the absence of severe serotonergic damage.

Authors+Show Affiliations

Neuroscience and Behavior Program, Tobin Hall, 135 Hicks Way, University of Massachusetts, Amherst, MA 01003, USA.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15582680

Citation

Piper, Brian J., and Jerrold S. Meyer. "Memory Deficit and Reduced Anxiety in Young Adult Rats Given Repeated Intermittent MDMA Treatment During the Periadolescent Period." Pharmacology, Biochemistry, and Behavior, vol. 79, no. 4, 2004, pp. 723-31.
Piper BJ, Meyer JS. Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period. Pharmacol Biochem Behav. 2004;79(4):723-31.
Piper, B. J., & Meyer, J. S. (2004). Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period. Pharmacology, Biochemistry, and Behavior, 79(4), pp. 723-31.
Piper BJ, Meyer JS. Memory Deficit and Reduced Anxiety in Young Adult Rats Given Repeated Intermittent MDMA Treatment During the Periadolescent Period. Pharmacol Biochem Behav. 2004;79(4):723-31. PubMed PMID: 15582680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Memory deficit and reduced anxiety in young adult rats given repeated intermittent MDMA treatment during the periadolescent period. AU - Piper,Brian J, AU - Meyer,Jerrold S, PY - 2004/06/23/received PY - 2004/09/30/revised PY - 2004/10/01/accepted PY - 2004/12/8/pubmed PY - 2005/4/30/medline PY - 2004/12/8/entrez SP - 723 EP - 31 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol. Biochem. Behav. VL - 79 IS - 4 N2 - 3,4-Methylenedioxymethamphetamine (MDMA, or "Ecstasy") is a popular recreational drug among adolescents that is often taken primarily on weekends. The goals of this study were to develop a model of the typical intermittent pattern of human MDMA use in periadolescent rats and to determine the behavioral consequences of MDMA exposure in this model. Male Sprague-Dawley rats received s.c. injections of 10 mg/kg of MDMA or saline twice daily with an interdose interval of 4 h. Treatments were given every fifth day from postnatal day (PD) 35 to PD 60. Beginning at PD 65, the animals were tested for open-field activity, object recognition memory, and anxiety-related behaviors in the elevated plus-maze. Brain tissues were collected at PD 70 for determination of radiolabeled paroxetine binding to the serotonin transporter (SERT) in the neocortex and hippocampus. Repeated MDMA administration led to a reduced rate of weight gain that was evident by PD 50. There was no treatment effect on ambulatory behavior in the open-field. However, the MDMA group displayed an impairment of object recognition memory and reduced anxiety as indicated by a twofold increase in open-arm duration in the elevated plus-maze. Only modest decreases in SERT binding were observed, although there was a significant negative correlation between hippocampal SERT levels and open-arm duration within the MDMA group. These findings demonstrate that intermittent MDMA exposure during the adolescent period of development can influence subsequent cognitive and affective functioning in the absence of severe serotonergic damage. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/15582680/Memory_deficit_and_reduced_anxiety_in_young_adult_rats_given_repeated_intermittent_MDMA_treatment_during_the_periadolescent_period_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(04)00321-1 DB - PRIME DP - Unbound Medicine ER -