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The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland.

Abstract

Low plasma folate and its derivatives have been linked with depressive disorders in studies dating back over 30 years. A thermolabile variant (677C>T) of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with low serum folate. The present study aimed to explore whether the thermolabile variant of MTHFR is associated with a vulnerability to depressive episodes. MTHFR C677T genotype frequencies in a cohort of patients (mean age 48 years) with depressive disorder (n = 100) were compared with those in age- and sex-matched controls. Serum levels of folate, homocysteine and vitamin B(12) were also compared between groups. The thermolabile variant of MTHFR was significantly more common in the group with a history of depressive disorder (P= 0.03). Serum levels of folate, homocysteine and vitamin B(12) did not differ significantly between groups. A MTHFR C677T genotype is associated with increased risk of depressive episodes in this homogenous patient population.

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  • Authors+Show Affiliations

    ,

    Department of Mental Health, Queen's University Belfast, Belfast BT9 7BL, UK. chriskelly@bch.n-i.nhs.uk

    , , , , , ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Cohort Studies
    Depressive Disorder
    Female
    Folic Acid
    Gene Frequency
    Genotype
    Homocystine
    Humans
    Ireland
    Male
    Methylenetetrahydrofolate Reductase (NADPH2)
    Middle Aged
    Polymorphism, Genetic
    Vitamin B 12

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    15582924

    Citation

    Kelly, Christopher B., et al. "The MTHFR C677T Polymorphism Is Associated With Depressive Episodes in Patients From Northern Ireland." Journal of Psychopharmacology (Oxford, England), vol. 18, no. 4, 2004, pp. 567-71.
    Kelly CB, McDonnell AP, Johnston TG, et al. The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland. J Psychopharmacol (Oxford). 2004;18(4):567-71.
    Kelly, C. B., McDonnell, A. P., Johnston, T. G., Mulholland, C., Cooper, S. J., McMaster, D., ... Whitehead, A. S. (2004). The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland. Journal of Psychopharmacology (Oxford, England), 18(4), pp. 567-71.
    Kelly CB, et al. The MTHFR C677T Polymorphism Is Associated With Depressive Episodes in Patients From Northern Ireland. J Psychopharmacol (Oxford). 2004;18(4):567-71. PubMed PMID: 15582924.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland. AU - Kelly,Christopher B, AU - McDonnell,Anne P, AU - Johnston,Timothy G, AU - Mulholland,Ciaran, AU - Cooper,Stephen J, AU - McMaster,Dorothy, AU - Evans,Alun, AU - Whitehead,Alexander S, PY - 2004/12/8/pubmed PY - 2005/4/13/medline PY - 2004/12/8/entrez SP - 567 EP - 71 JF - Journal of psychopharmacology (Oxford, England) JO - J. Psychopharmacol. (Oxford) VL - 18 IS - 4 N2 - Low plasma folate and its derivatives have been linked with depressive disorders in studies dating back over 30 years. A thermolabile variant (677C>T) of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with low serum folate. The present study aimed to explore whether the thermolabile variant of MTHFR is associated with a vulnerability to depressive episodes. MTHFR C677T genotype frequencies in a cohort of patients (mean age 48 years) with depressive disorder (n = 100) were compared with those in age- and sex-matched controls. Serum levels of folate, homocysteine and vitamin B(12) were also compared between groups. The thermolabile variant of MTHFR was significantly more common in the group with a history of depressive disorder (P= 0.03). Serum levels of folate, homocysteine and vitamin B(12) did not differ significantly between groups. A MTHFR C677T genotype is associated with increased risk of depressive episodes in this homogenous patient population. SN - 0269-8811 UR - https://www.unboundmedicine.com/medline/citation/15582924/full_citation L2 - http://journals.sagepub.com/doi/full/10.1177/0269881104047285?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -