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Airway remodeling: a comparison between fatal and nonfatal asthma.
J Asthma. 2004 Sep; 41(6):631-8.JA

Abstract

BACKGROUND

Airway remodeling has been recently one of the main goals in asthma research because it has been implicated to influence airway behavior and evolution of asthma; hence, important in long-term followup of asthmatic patients.

METHODS

Airways of fatal asthma (n=3), non-fatal asthma (n=3) and control cases (n=4) were studied using morphometry and immunohistochemical and H&E staining.

RESULTS

The basement membrane was thicker in the cartilaginous and membranous airways of fatal and non-fatal asthma groups compared to the control group (p<0.05). Smooth muscle shortening was greater in airways of fatal asthma cases while submucosal gland area and mucus plug occupying ratio were greater in fatal asthma large airways compared to the two other groups (p<0.01). Increased intact and degranulated mast cells were observed in smooth muscle and in submucosal gland of fatal asthma airways (p<0.01) and were associated with greater degree of smooth muscle shortening and larger submucosal gland area, respectively. Eosinophil and EG2+ cell infiltrations were greatest in lamina propria of airways of fatal asthma than in nonfatal and control cases (p<0.01), but were not associated with any airway structural change.

CONCLUSION

Increased infiltration of eosinophils in the lamina propria and mast cells in smooth muscle and submucosal glands may have a role in airway remodeling of fatal asthma airways but needs further investigation. Moreover, mast cells in cartilaginous airways may participate in the regulation of smooth muscle tone and mucous gland secretion and hyperplasia.

Authors+Show Affiliations

Chen FH
Department of Anatomy, Showa University School of Medicine, Tokyo, Japan.
Samson KT
No affiliation info available
Miura K
No affiliation info available
Ueno K
No affiliation info available
Odajima Y
No affiliation info available
Shougo T
No affiliation info available
Yoshitsugu Y
No affiliation info available
Shioda S
No affiliation info available

MeSH

AdultAirway ResistanceAnalysis of VarianceAsthmaAutopsyBasement MembraneBiopsy, NeedleCase-Control StudiesCell CountCell DegranulationFemaleHumansImmunohistochemistryLungMaleMast CellsMiddle AgedObserver VariationPhotomicrographyReference ValuesRespiratory MucosaSeverity of Illness IndexStatistics, Nonparametric

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15584312

Citation

Chen, Fen Hua, et al. "Airway Remodeling: a Comparison Between Fatal and Nonfatal Asthma." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 41, no. 6, 2004, pp. 631-8.
Chen FH, Samson KT, Miura K, et al. Airway remodeling: a comparison between fatal and nonfatal asthma. J Asthma. 2004;41(6):631-8.
Chen, F. H., Samson, K. T., Miura, K., Ueno, K., Odajima, Y., Shougo, T., Yoshitsugu, Y., & Shioda, S. (2004). Airway remodeling: a comparison between fatal and nonfatal asthma. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 41(6), 631-8.
Chen FH, et al. Airway Remodeling: a Comparison Between Fatal and Nonfatal Asthma. J Asthma. 2004;41(6):631-8. PubMed PMID: 15584312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Airway remodeling: a comparison between fatal and nonfatal asthma. AU - Chen,Fen Hua, AU - Samson,Karen Thursday, AU - Miura,Katsushi, AU - Ueno,Kozo, AU - Odajima,Yasuhei, AU - Shougo,Tokutome, AU - Yoshitsugu,Yamaguchi, AU - Shioda,Seiji, PY - 2004/12/9/pubmed PY - 2005/1/4/medline PY - 2004/12/9/entrez SP - 631 EP - 8 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 41 IS - 6 N2 - BACKGROUND: Airway remodeling has been recently one of the main goals in asthma research because it has been implicated to influence airway behavior and evolution of asthma; hence, important in long-term followup of asthmatic patients. METHODS: Airways of fatal asthma (n=3), non-fatal asthma (n=3) and control cases (n=4) were studied using morphometry and immunohistochemical and H&E staining. RESULTS: The basement membrane was thicker in the cartilaginous and membranous airways of fatal and non-fatal asthma groups compared to the control group (p<0.05). Smooth muscle shortening was greater in airways of fatal asthma cases while submucosal gland area and mucus plug occupying ratio were greater in fatal asthma large airways compared to the two other groups (p<0.01). Increased intact and degranulated mast cells were observed in smooth muscle and in submucosal gland of fatal asthma airways (p<0.01) and were associated with greater degree of smooth muscle shortening and larger submucosal gland area, respectively. Eosinophil and EG2+ cell infiltrations were greatest in lamina propria of airways of fatal asthma than in nonfatal and control cases (p<0.01), but were not associated with any airway structural change. CONCLUSION: Increased infiltration of eosinophils in the lamina propria and mast cells in smooth muscle and submucosal glands may have a role in airway remodeling of fatal asthma airways but needs further investigation. Moreover, mast cells in cartilaginous airways may participate in the regulation of smooth muscle tone and mucous gland secretion and hyperplasia. SN - 0277-0903 UR - https://www.unboundmedicine.com/medline/citation/15584312/Airway_remodeling:_a_comparison_between_fatal_and_nonfatal_asthma_ DB - PRIME DP - Unbound Medicine ER -