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Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats.
Am J Physiol Renal Physiol. 2005 Apr; 288(4):F810-5.AJ

Abstract

Transient exposure to ANG II results in the development of salt-sensitive hypertension in rats. This study was performed to determine whether a transient hypertensive episode can induce salt-sensitive hypertension in transgenic rats with inducible expression of the mouse Ren2 renin gene [strain name TGR(Cyp1a1-Ren2)]. Systolic blood pressures were measured in conscious male Cyp1a1-Ren2 rats (n = 6) during control conditions and during dietary administration of indole-3-carbinol (I3C; 0.15%, wt/wt), for 14 days. Systolic pressure increased from 135 +/- 5 to 233 +/- 7 mmHg by day 14. I3C administration was terminated and blood pressure returned to normal levels (137 +/- 5 mmHg) within 10 days. Subsequently, the rats were placed on a high-salt diet (8% NaCl) for 10 days. Systolic pressure increased by 34 +/- 2 mmHg throughout 10 days of the high-salt diet. Neither glomerular filtration rate nor renal plasma flow was altered in Cyp1a1-Ren2 rats with salt-sensitive hypertension. In a separate group of male Cyp1a1-Ren2 rats (n = 6) transiently induced with 0.15% I3C for 14 days, administration of the superoxide dismutase mimetic tempol (4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl, 2 mM) attenuated the increase in systolic pressure induced by high salt. Systolic pressure increased by only 11 +/- 1 mmHg throughout 8 days of a high-salt diet and tempol administration. Thus transient induction of ANG II-dependent hypertension via activation of the Cyp1a1-Ren2 transgene induces salt-sensitive hypertension in these transgenic rats. The attenuation by tempol of the high salt-induced blood pressure elevation indicates that ANG II-induced production of superoxide anion contributes to the development of salt-sensitive hypertension after transient induction of ANG II-dependent hypertension.

Authors+Show Affiliations

Dept. of Physiology, Tulane Univ. Health Sciences Ctr., 1430 Tulane Ave., SL39, New Orleans, LA 70112, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15585671

Citation

Howard, Laura L., et al. "Salt-sensitive Hypertension Develops After Transient Induction of ANG II-dependent Hypertension in Cyp1a1-Ren2 Transgenic Rats." American Journal of Physiology. Renal Physiology, vol. 288, no. 4, 2005, pp. F810-5.
Howard LL, Patterson ME, Mullins JJ, et al. Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats. Am J Physiol Renal Physiol. 2005;288(4):F810-5.
Howard, L. L., Patterson, M. E., Mullins, J. J., & Mitchell, K. D. (2005). Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats. American Journal of Physiology. Renal Physiology, 288(4), F810-5.
Howard LL, et al. Salt-sensitive Hypertension Develops After Transient Induction of ANG II-dependent Hypertension in Cyp1a1-Ren2 Transgenic Rats. Am J Physiol Renal Physiol. 2005;288(4):F810-5. PubMed PMID: 15585671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats. AU - Howard,Laura L, AU - Patterson,Matthew E, AU - Mullins,John J, AU - Mitchell,Kenneth D, Y1 - 2004/12/07/ PY - 2004/12/9/pubmed PY - 2005/4/19/medline PY - 2004/12/9/entrez SP - F810 EP - 5 JF - American journal of physiology. Renal physiology JO - Am. J. Physiol. Renal Physiol. VL - 288 IS - 4 N2 - Transient exposure to ANG II results in the development of salt-sensitive hypertension in rats. This study was performed to determine whether a transient hypertensive episode can induce salt-sensitive hypertension in transgenic rats with inducible expression of the mouse Ren2 renin gene [strain name TGR(Cyp1a1-Ren2)]. Systolic blood pressures were measured in conscious male Cyp1a1-Ren2 rats (n = 6) during control conditions and during dietary administration of indole-3-carbinol (I3C; 0.15%, wt/wt), for 14 days. Systolic pressure increased from 135 +/- 5 to 233 +/- 7 mmHg by day 14. I3C administration was terminated and blood pressure returned to normal levels (137 +/- 5 mmHg) within 10 days. Subsequently, the rats were placed on a high-salt diet (8% NaCl) for 10 days. Systolic pressure increased by 34 +/- 2 mmHg throughout 10 days of the high-salt diet. Neither glomerular filtration rate nor renal plasma flow was altered in Cyp1a1-Ren2 rats with salt-sensitive hypertension. In a separate group of male Cyp1a1-Ren2 rats (n = 6) transiently induced with 0.15% I3C for 14 days, administration of the superoxide dismutase mimetic tempol (4-hydroxy-2,2,6,6-tetramethyl piperidinoxyl, 2 mM) attenuated the increase in systolic pressure induced by high salt. Systolic pressure increased by only 11 +/- 1 mmHg throughout 8 days of a high-salt diet and tempol administration. Thus transient induction of ANG II-dependent hypertension via activation of the Cyp1a1-Ren2 transgene induces salt-sensitive hypertension in these transgenic rats. The attenuation by tempol of the high salt-induced blood pressure elevation indicates that ANG II-induced production of superoxide anion contributes to the development of salt-sensitive hypertension after transient induction of ANG II-dependent hypertension. SN - 1931-857X UR - https://www.unboundmedicine.com/medline/citation/15585671/Salt_sensitive_hypertension_develops_after_transient_induction_of_ANG_II_dependent_hypertension_in_Cyp1a1_Ren2_transgenic_rats_ L2 - http://www.physiology.org/doi/full/10.1152/ajprenal.00148.2004?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -