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Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor kappaB in peripheral blood mononuclear cells from healthy men.
Am J Clin Nutr. 2004 Dec; 80(6):1487-91.AJ

Abstract

BACKGROUND

Nuclear transcription factor kappaB (NF-kappaB) plays an important role in atherosclerosis by modulating gene expression. Postprandial lipemia has been correlated with an increase in NF-kappaB activation in vascular cells and it is associated with an increase in postprandial triacylglycerol-rich lipoproteins, which are involved in the development of atherosclerotic plaque.

OBJECTIVE

The objective of this study was to determine the effect of the intakes of 3 different foods with different fat compositions on the postprandial activation of monocyte NF-kappaB.

DESIGN

Eight healthy men followed a 4-wk baseline diet and then consumed 3 fat-load meals consisting of 1 g fat/kg body wt (65% fat) according to a randomized crossover design. Each meal had a different fatty acid composition, and the consumption of each meal was separated by 1 wk. The compositions of the 3 test meals were as follows: olive oil meal [22% saturated fatty acids (SFAs), 38% monounsaturated fatty acids (MUFAs), 4% polyunsaturated fatty acids (PUFAs), and 0.7% alpha-linolenic acid], butter meal (38% SFAs, 22% MUFAs, 4% PUFAs, and 0.7% alpha-linolenic acid), and walnut meal (20% SFAs, 24% MUFAs, 16% PUFAs, and 4% alpha-linolenic acid).

RESULTS

Ingestion of the olive oil meal did not elicit NF-kappaB activation compared with ingestion of either the butter meal at 3 h (P <0.05) or the walnut meal at 9 h (P <0.05). There was no significant difference in the postprandial triacylglycerol response between the 3 meals.

CONCLUSIONS

Consumption of an olive oil-enriched meal does not activate NF-kappaB in monocytes as do butter and walnut-enriched meals. This effect could enhance the cardioprotective effect of olive oil-enriched diets.

Authors+Show Affiliations

Lipids and Arteriosclerosis Unit, Hospital Universitario Reina Sofía, Córdoba, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15585759

Citation

Bellido, Cecilia, et al. "Butter and Walnuts, but Not Olive Oil, Elicit Postprandial Activation of Nuclear Transcription Factor kappaB in Peripheral Blood Mononuclear Cells From Healthy Men." The American Journal of Clinical Nutrition, vol. 80, no. 6, 2004, pp. 1487-91.
Bellido C, López-Miranda J, Blanco-Colio LM, et al. Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor kappaB in peripheral blood mononuclear cells from healthy men. Am J Clin Nutr. 2004;80(6):1487-91.
Bellido, C., López-Miranda, J., Blanco-Colio, L. M., Pérez-Martínez, P., Muriana, F. J., Martín-Ventura, J. L., Marín, C., Gómez, P., Fuentes, F., Egido, J., & Pérez-Jiménez, F. (2004). Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor kappaB in peripheral blood mononuclear cells from healthy men. The American Journal of Clinical Nutrition, 80(6), 1487-91.
Bellido C, et al. Butter and Walnuts, but Not Olive Oil, Elicit Postprandial Activation of Nuclear Transcription Factor kappaB in Peripheral Blood Mononuclear Cells From Healthy Men. Am J Clin Nutr. 2004;80(6):1487-91. PubMed PMID: 15585759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Butter and walnuts, but not olive oil, elicit postprandial activation of nuclear transcription factor kappaB in peripheral blood mononuclear cells from healthy men. AU - Bellido,Cecilia, AU - López-Miranda,José, AU - Blanco-Colio,Luis Miguel, AU - Pérez-Martínez,Pablo, AU - Muriana,Francisco José, AU - Martín-Ventura,José Luis, AU - Marín,Carmen, AU - Gómez,Purificación, AU - Fuentes,Francisco, AU - Egido,Jesús, AU - Pérez-Jiménez,Francisco, PY - 2004/12/9/pubmed PY - 2005/1/7/medline PY - 2004/12/9/entrez SP - 1487 EP - 91 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 80 IS - 6 N2 - BACKGROUND: Nuclear transcription factor kappaB (NF-kappaB) plays an important role in atherosclerosis by modulating gene expression. Postprandial lipemia has been correlated with an increase in NF-kappaB activation in vascular cells and it is associated with an increase in postprandial triacylglycerol-rich lipoproteins, which are involved in the development of atherosclerotic plaque. OBJECTIVE: The objective of this study was to determine the effect of the intakes of 3 different foods with different fat compositions on the postprandial activation of monocyte NF-kappaB. DESIGN: Eight healthy men followed a 4-wk baseline diet and then consumed 3 fat-load meals consisting of 1 g fat/kg body wt (65% fat) according to a randomized crossover design. Each meal had a different fatty acid composition, and the consumption of each meal was separated by 1 wk. The compositions of the 3 test meals were as follows: olive oil meal [22% saturated fatty acids (SFAs), 38% monounsaturated fatty acids (MUFAs), 4% polyunsaturated fatty acids (PUFAs), and 0.7% alpha-linolenic acid], butter meal (38% SFAs, 22% MUFAs, 4% PUFAs, and 0.7% alpha-linolenic acid), and walnut meal (20% SFAs, 24% MUFAs, 16% PUFAs, and 4% alpha-linolenic acid). RESULTS: Ingestion of the olive oil meal did not elicit NF-kappaB activation compared with ingestion of either the butter meal at 3 h (P <0.05) or the walnut meal at 9 h (P <0.05). There was no significant difference in the postprandial triacylglycerol response between the 3 meals. CONCLUSIONS: Consumption of an olive oil-enriched meal does not activate NF-kappaB in monocytes as do butter and walnut-enriched meals. This effect could enhance the cardioprotective effect of olive oil-enriched diets. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/15585759/Butter_and_walnuts_but_not_olive_oil_elicit_postprandial_activation_of_nuclear_transcription_factor_kappaB_in_peripheral_blood_mononuclear_cells_from_healthy_men_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/80.6.1487 DB - PRIME DP - Unbound Medicine ER -