Tags

Type your tag names separated by a space and hit enter

Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis.
J Pathol. 2005 Jan; 205(1):92-101.JP

Abstract

Primary extramedullary plasmacytomas are infrequent, typically solitary, plasma cell neoplasms that generally pursue an indolent clinical course but may, rarely, convert to multiple myeloma. Phenotypic differences between these two entities are not well defined. Twenty-eight cases of primary extramedullary plasmacytoma and 26 cases of both medullary (n = 17) and extramedullary (n = 9) multiple myeloma were analysed for the expression of proteins known to play a role in the biology of multiple myeloma. Immunohistochemistry was performed on paraffin wax sections using antibodies against cyclin D1, Bcl-2, Bcl-xL, p27, p21, p53, MIB1, CD20, and CD56. Twenty-three extramedullary plasmacytomas were localized in the upper aerodigestive tract, four in the lymph nodes, and one in the testis. There was a strong male predominance (M : F = 6 : 1). None of the patients died from the disease or progressed to multiple myeloma (mean follow-up 50 months). Nine patients developed local relapse and one patient's tumour evolved into a B-cell non-Hodgkin's lymphoma. In contrast to both intra- and extra-medullary multiple myeloma, extramedullary plasmacytoma showed absence of cyclin D1 (p < 0.001) and infrequent expression of CD56 (p < 0.001). Furthermore, extramedullary plasmacytomas were characterized by weaker staining for Bcl-2 protein and rare overexpression of p21 and p53. In comparison to extramedullary multiple myeloma, extramedullary plasmacytoma showed a more mature morphology and lower proliferation indices (p = 0.008). There was no association between the phenotypic parameters investigated and clinical outcome in extramedullary plasmacytoma. In summary, extramedullary plasmacytoma and multiple myeloma show significant immunophenotypic differences, some of which may be of both diagnostic utility and biological relevance.

Authors+Show Affiliations

Institute of Pathology, Technical University of Munich, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15586381

Citation

Kremer, Marcus, et al. "Primary Extramedullary Plasmacytoma and Multiple Myeloma: Phenotypic Differences Revealed By Immunohistochemical Analysis." The Journal of Pathology, vol. 205, no. 1, 2005, pp. 92-101.
Kremer M, Ott G, Nathrath M, et al. Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol. 2005;205(1):92-101.
Kremer, M., Ott, G., Nathrath, M., Specht, K., Stecker, K., Alexiou, C., Quintanilla-Martinez, L., & Fend, F. (2005). Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. The Journal of Pathology, 205(1), 92-101.
Kremer M, et al. Primary Extramedullary Plasmacytoma and Multiple Myeloma: Phenotypic Differences Revealed By Immunohistochemical Analysis. J Pathol. 2005;205(1):92-101. PubMed PMID: 15586381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. AU - Kremer,Marcus, AU - Ott,German, AU - Nathrath,Michaela, AU - Specht,Katja, AU - Stecker,Katrin, AU - Alexiou,Christoph, AU - Quintanilla-Martinez,Leticia, AU - Fend,Falko, PY - 2004/12/9/pubmed PY - 2005/2/3/medline PY - 2004/12/9/entrez SP - 92 EP - 101 JF - The Journal of pathology JO - J. Pathol. VL - 205 IS - 1 N2 - Primary extramedullary plasmacytomas are infrequent, typically solitary, plasma cell neoplasms that generally pursue an indolent clinical course but may, rarely, convert to multiple myeloma. Phenotypic differences between these two entities are not well defined. Twenty-eight cases of primary extramedullary plasmacytoma and 26 cases of both medullary (n = 17) and extramedullary (n = 9) multiple myeloma were analysed for the expression of proteins known to play a role in the biology of multiple myeloma. Immunohistochemistry was performed on paraffin wax sections using antibodies against cyclin D1, Bcl-2, Bcl-xL, p27, p21, p53, MIB1, CD20, and CD56. Twenty-three extramedullary plasmacytomas were localized in the upper aerodigestive tract, four in the lymph nodes, and one in the testis. There was a strong male predominance (M : F = 6 : 1). None of the patients died from the disease or progressed to multiple myeloma (mean follow-up 50 months). Nine patients developed local relapse and one patient's tumour evolved into a B-cell non-Hodgkin's lymphoma. In contrast to both intra- and extra-medullary multiple myeloma, extramedullary plasmacytoma showed absence of cyclin D1 (p < 0.001) and infrequent expression of CD56 (p < 0.001). Furthermore, extramedullary plasmacytomas were characterized by weaker staining for Bcl-2 protein and rare overexpression of p21 and p53. In comparison to extramedullary multiple myeloma, extramedullary plasmacytoma showed a more mature morphology and lower proliferation indices (p = 0.008). There was no association between the phenotypic parameters investigated and clinical outcome in extramedullary plasmacytoma. In summary, extramedullary plasmacytoma and multiple myeloma show significant immunophenotypic differences, some of which may be of both diagnostic utility and biological relevance. SN - 0022-3417 UR - https://www.unboundmedicine.com/medline/citation/15586381/Primary_extramedullary_plasmacytoma_and_multiple_myeloma:_phenotypic_differences_revealed_by_immunohistochemical_analysis_ L2 - https://doi.org/10.1002/path.1680 DB - PRIME DP - Unbound Medicine ER -