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The composition, geographical variation and antimicrobial activity of Lippia javanica (Verbenaceae) leaf essential oils.
J Ethnopharmacol. 2005 Jan 04; 96(1-2):271-7.JE

Abstract

Lippia javanica is widely distributed throughout South Africa where it is used extensively in traditional herbal preparations. An infusion of the leaves is commonly used as a decongestant for colds and coughs. A preliminary study indicated that the essential oil chemistry varies dramatically both within and between natural plant populations. As the antimicrobial activity may be directly related to the specific composition of the oil, the activity may also fluctuate. The aerial parts of Lippia javanica were collected from various localities in southern Africa to study the essential oil composition and the antimicrobial activity thereof. The hydrodistilled essential oils were analysed by GC/MS and a cluster analysis was performed on the essential oil dataset. From 16 samples (representing five natural populations), 5 chemotypes were identified; a myrcenone rich-type (36-62%), a carvone rich-type (61-73%), a piperitenone rich-type (32-48%), an ipsenone rich-type (42-61%) and a linalool rich-type (>65%). The myrcenone and linalool chemotypes have been mentioned in the literature but the carvone, ipsenone and piperitenone chemotypes have not previously been reported for Lippia javanica. Time kill studies were performed on three microbial respiratory isolates to document the scientific rationale of using Lippia to treat respiratory complaints in traditional herbal medicine. Klebsiella pneumoniae, Cryptococcus neoformans and Bacillus cereus showed reduction in microbial populations with the strongest bacteriostatic effect observed for Klebsiella pneumoniae.

Authors+Show Affiliations

Department of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa. viljoenam@therapy.wits.ac.zaNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15588679

Citation

Viljoen, A M., et al. "The Composition, Geographical Variation and Antimicrobial Activity of Lippia Javanica (Verbenaceae) Leaf Essential Oils." Journal of Ethnopharmacology, vol. 96, no. 1-2, 2005, pp. 271-7.
Viljoen AM, Subramoney S, van Vuuren SF, et al. The composition, geographical variation and antimicrobial activity of Lippia javanica (Verbenaceae) leaf essential oils. J Ethnopharmacol. 2005;96(1-2):271-7.
Viljoen, A. M., Subramoney, S., van Vuuren, S. F., Başer, K. H., & Demirci, B. (2005). The composition, geographical variation and antimicrobial activity of Lippia javanica (Verbenaceae) leaf essential oils. Journal of Ethnopharmacology, 96(1-2), 271-7.
Viljoen AM, et al. The Composition, Geographical Variation and Antimicrobial Activity of Lippia Javanica (Verbenaceae) Leaf Essential Oils. J Ethnopharmacol. 2005 Jan 4;96(1-2):271-7. PubMed PMID: 15588679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The composition, geographical variation and antimicrobial activity of Lippia javanica (Verbenaceae) leaf essential oils. AU - Viljoen,A M, AU - Subramoney,S, AU - van Vuuren,S F, AU - Başer,K H C, AU - Demirci,B, PY - 2004/03/08/received PY - 2004/08/09/revised PY - 2004/09/08/accepted PY - 2004/12/14/pubmed PY - 2005/6/14/medline PY - 2004/12/14/entrez SP - 271 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 96 IS - 1-2 N2 - Lippia javanica is widely distributed throughout South Africa where it is used extensively in traditional herbal preparations. An infusion of the leaves is commonly used as a decongestant for colds and coughs. A preliminary study indicated that the essential oil chemistry varies dramatically both within and between natural plant populations. As the antimicrobial activity may be directly related to the specific composition of the oil, the activity may also fluctuate. The aerial parts of Lippia javanica were collected from various localities in southern Africa to study the essential oil composition and the antimicrobial activity thereof. The hydrodistilled essential oils were analysed by GC/MS and a cluster analysis was performed on the essential oil dataset. From 16 samples (representing five natural populations), 5 chemotypes were identified; a myrcenone rich-type (36-62%), a carvone rich-type (61-73%), a piperitenone rich-type (32-48%), an ipsenone rich-type (42-61%) and a linalool rich-type (>65%). The myrcenone and linalool chemotypes have been mentioned in the literature but the carvone, ipsenone and piperitenone chemotypes have not previously been reported for Lippia javanica. Time kill studies were performed on three microbial respiratory isolates to document the scientific rationale of using Lippia to treat respiratory complaints in traditional herbal medicine. Klebsiella pneumoniae, Cryptococcus neoformans and Bacillus cereus showed reduction in microbial populations with the strongest bacteriostatic effect observed for Klebsiella pneumoniae. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/15588679/The_composition_geographical_variation_and_antimicrobial_activity_of_Lippia_javanica__Verbenaceae__leaf_essential_oils_ DB - PRIME DP - Unbound Medicine ER -