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Endogenous prostacyclin increases neuronal nitric oxide release in mesenteric artery from spontaneously hypertensive rats.
Eur J Pharmacol. 2004 Dec 15; 506(2):151-6.EJ

Abstract

The aim of this study was to analyse the possible influence of endogenous prostacyclin on neuronal nitric oxide (NO) release induced by electrical field stimulation in mesenteric arteries from spontaneously hypertensive rats (SHR). Preincubation with the prostacyclin synthesis inhibitor tranylcypromine decreased NO release induced by electrical field stimulation, which was reversed by exogenous prostacyclin. Preincubation with tranylcypromine increased basal and electrical field stimulation-induced [3H]noradrenaline release. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl esther (L-NAME) increased the vasoconstrictor response induced by electrical field stimulation. In the presence of tranylcypromine, L-NAME did not modify the vasoconstrictor response induced by electrical field stimulation. In the presence of tranylcypromine and prostacyclin, LNAME increased the vasoconstrictor response to electrical field stimulation. These results indicate that endogenous prostacyclin positively modulates the neuronal NO release induced by electrical field stimulation and that this neuronal NO participates in the regulation of the vasomotor response.

Authors+Show Affiliations

Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma, C/ Arzobispo Morcillo, 4, 28029- Madrid, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15588735

Citation

Ferrer, Mercedes, et al. "Endogenous Prostacyclin Increases Neuronal Nitric Oxide Release in Mesenteric Artery From Spontaneously Hypertensive Rats." European Journal of Pharmacology, vol. 506, no. 2, 2004, pp. 151-6.
Ferrer M, Salaices M, Balfagón G. Endogenous prostacyclin increases neuronal nitric oxide release in mesenteric artery from spontaneously hypertensive rats. Eur J Pharmacol. 2004;506(2):151-6.
Ferrer, M., Salaices, M., & Balfagón, G. (2004). Endogenous prostacyclin increases neuronal nitric oxide release in mesenteric artery from spontaneously hypertensive rats. European Journal of Pharmacology, 506(2), 151-6.
Ferrer M, Salaices M, Balfagón G. Endogenous Prostacyclin Increases Neuronal Nitric Oxide Release in Mesenteric Artery From Spontaneously Hypertensive Rats. Eur J Pharmacol. 2004 Dec 15;506(2):151-6. PubMed PMID: 15588735.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endogenous prostacyclin increases neuronal nitric oxide release in mesenteric artery from spontaneously hypertensive rats. AU - Ferrer,Mercedes, AU - Salaices,Mercedes, AU - Balfagón,Gloria, PY - 2004/03/29/received PY - 2004/10/25/revised PY - 2004/11/02/accepted PY - 2004/12/14/pubmed PY - 2005/5/7/medline PY - 2004/12/14/entrez SP - 151 EP - 6 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 506 IS - 2 N2 - The aim of this study was to analyse the possible influence of endogenous prostacyclin on neuronal nitric oxide (NO) release induced by electrical field stimulation in mesenteric arteries from spontaneously hypertensive rats (SHR). Preincubation with the prostacyclin synthesis inhibitor tranylcypromine decreased NO release induced by electrical field stimulation, which was reversed by exogenous prostacyclin. Preincubation with tranylcypromine increased basal and electrical field stimulation-induced [3H]noradrenaline release. The nitric oxide synthase inhibitor Nomega-nitro-L-arginine methyl esther (L-NAME) increased the vasoconstrictor response induced by electrical field stimulation. In the presence of tranylcypromine, L-NAME did not modify the vasoconstrictor response induced by electrical field stimulation. In the presence of tranylcypromine and prostacyclin, LNAME increased the vasoconstrictor response to electrical field stimulation. These results indicate that endogenous prostacyclin positively modulates the neuronal NO release induced by electrical field stimulation and that this neuronal NO participates in the regulation of the vasomotor response. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15588735/Endogenous_prostacyclin_increases_neuronal_nitric_oxide_release_in_mesenteric_artery_from_spontaneously_hypertensive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(04)01257-9 DB - PRIME DP - Unbound Medicine ER -